Results 21 to 30 of about 471,867 (378)

Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting.

PLoS ONE, 2022
The ability to predict nucleic acid hybridization energies has been greatly enabling for many applications, but predictive models require painstaking experimentation, which may limit expansion to non-natural nucleic acid analogues and chemistries.
Siyuan S Wang, Erhu Xiong, Sanchita Bhadra, Andrew D Ellington   +3 more
doaj   +1 more source

Application of Graphene FET Nucleic Acid Biosensor in Human Motion Measurement [PDF]

International Journal Bioautomation, 2018
In order to explore the application of graphene field effect transistor (FET) nucleic acid biosensor, the sensitivity and selectivity of nano FET biosensor detection are improved by the large physical surface ratio, high electron mobility, excellent ...
Hang Yin
doaj   +1 more source

Complex Nucleic Acid Hybridization Reactions inside Capillary-Driven Microfluidic Chips.

Small, 2020
Nucleic acid hybridization reactions play an important role in many (bio)chemical fields, for example, for the development of portable point-of-care diagnostics, and often such applications require nucleic acid-based reaction systems that ideally run ...
Marie L. Salva, M. Rocca, Yong Hu, E. Delamarche, C. Niemeyer   +4 more
semanticscholar   +1 more source

Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays

Micromachines, 2023
The use of lateral flow assays to detect nucleic acid targets has many applications including point-of-care diagnostics, environmental monitoring, and food safety.
Kira Hallerbach, Khadijeh Khederlou, Lael Wentland, Lana Senten, Steven Brentano, Brian Keefe, Elain Fu   +6 more
doaj   +1 more source

Highly efficient and robust π-FISH rainbow for multiplexed in situ detection of diverse biomolecules

Nature Communications, 2023
Fluorescence in situ hybridization (FISH) methods with high sensitivity are needed. Here the authors develop multiplex πFISH rainbow to detect a range of biomolecules; they also combine this with the hybridization chain reaction to develop πFISH ...
Yingfeng Tao, Xiaoliu Zhou, Leqiang Sun, Da Lin, Huaiyuan Cai, Xi Chen, Wei Zhou, Bing Yang, Zhe Hu, Jing Yu, Jing Zhang, Xiaoqing Yang, Fang Yang, Bang Shen, Wenbao Qi, Zhenfang Fu, Jinxia Dai, Gang Cao   +17 more
doaj   +1 more source

Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]

, 2020
The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico, Madder, Annemieke, Mancin, Fabrizio, Manicardi, Alex, Rosa-Gastaldo, Daniele   +4 more
core   +2 more sources

Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]

, 2013
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot, A. E. Pozhitkov, A. Halperin, A. Harrison, A. Ott, Amend, B. M. Pettitt, Berger, Binder, Binder, Binder, Binder, Bolstad, Bullard, Burden, Burden, C. Gibas, C. J. Burden, Chou, Chou, Czypionka, D. P. Kreil, D. Tautz, E. Carlon, Fasold, Fasold, Fiche, Fuchs, H. Binder, Halperin, Harr, Harrison, He, Heim, Held, Hooyberghs, Huettel, Iltumur, Irizarry, Irizarry, Irizarry, Irving, J. Hooyberghs, Kane, L. J. Gamble, Lee, Lee, Letowski, Li, Liebich, Lockhart, Luebke, Marshall, Matveeva, Mueckstein, Mulders, Naiser, Naiser, P. A. Noble, Pingel, Pozhitkov, R. Levicky, Relogio, Rouillard, Tanaka, Trapp, Upton, Vainrub, Wodicka, Yu, Zhang   +70 more
core   +3 more sources

Nucleic Acid Analysis Using Multifunctional Hybridization Sensors

Proceedings, 2017
Hybridization of nucleic acid probes remains one of the most common strategies for sensing of [...]
Dmitry M. Kolpashchikov
doaj   +1 more source

Microfluidic Chip for the Electrochemical Detection of MicroRNAs: Methylene Blue Increasing the Specificity of the Biosensor

Frontiers in Chemistry, 2022
MicroRNAs (miRNAs) are biomarkers involved in biological processes that are released by cells and found in biological fluids such as blood. The development of nucleic acid-based biosensors has significantly increased in the past 10 years because the ...
Claire Poujouly, Jérémy Le Gall, Martina Freisa, Djamila Kechkeche, David Bouville, Jihed Khemir, Pedro Gonzalez-Losada, Jean Gamby   +7 more
doaj   +1 more source

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers [PDF]

Pharmaceutics, 2020
Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects ...
Sybil Obuobi, Nataša Škalko-Basnet
openaire   +4 more sources