Results 51 to 60 of about 57,712 (282)

The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA

, 2010
The Nep1 (Emg1) SPOUT-class methyltransferase is an essential ribosome assembly factor and the human Bowen–Conradi syndrome (BCS) is caused by a specific Nep1D86G mutation. We recently showed in vitro that Methanocaldococcus jannaschii Nep1 is a sequence-
Valeska Schilling, Jan Philip Wurm, Britta Meyer, Michael Karas, Kötter, Peter, Bahr, Ute, Schilling, Valeska, Buchhaupt, Markus, Wöhnert, Jens, Ute Bahr, Karl-Dieter Entian, Matthias S. Leisegang, Karas, Michael (Prof. Dr.), Martin Held, Heckel, Alexander, Leisegang, Matthias S., Peter Kötter, Markus T. Bohnsack, Entian, Karl-Dieter, Markus Buchhaupt, Bohnsack, Markus, Held, Martin, Alexander Heckel, Meyer, Britta, Leisegang, Matthias, Jens Wöhnert, Karas, Michael, Wurm, Jan Philip   +27 more
core   +1 more source

Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]

, 2007
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David, Dlakic, Mensur, Dez, Christophe   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Inhibiting eukaryotic ribosome biogenesis: Mining new tools for basic research and medical applications

Microbial Cell, 2019
The formation of new ribosomes is a fundamental cellular process for each living cell and is tightly interwoven with cell cycle control and proliferation.
Lisa Kofler, Michael Prattes, Helmut Bergler   +2 more
doaj   +1 more source

Ribosomal DNA-connecting ribosome biogenesis and chromosome biology [PDF]

Chromosome Research, 2019
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome.
Lev, Porokhovnik, Jennifer L, Gerton
openaire   +2 more sources

Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics

, 2009
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments.
Edward M. Marcotte, Lee Insuk, Arlen W. Johnson, Emily Moradi, Marcotte Edward M., Zhihua Li, Johnson Arlen W., Lee, Insuk, Li Zhihua, Nai-Jung Hung, Li, Zhihua, Johnson, Arlen W., Arlen W Johnson, Marcotte, Edward M., Edward M Marcotte, Hung Nai-Jung, Moradi, Emily, Insuk Lee, Moradi Emily, Hung, Nai-Jung   +19 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Sharma, Sunny, Watzinger, Peter, Lamberth, Stefanie, Entian, Karl-Dieter, Kötter, Peter, Peifer, Christian   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source