Results 51 to 60 of about 87,402 (287)
Frontiers in Oncology, 2021 Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.
Lanjuan Mi +18 more
doaj +1 more source
Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]
, 2016 Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith +6 more
core +2 more sources
Ribosome biogenesis: Stripping for AAAction? [PDF]
Current Biology, 2001 Ribosomal subunits are assembled in the nucleolus before being transported to the cytoplasm. Recent work has identified both a protein that may play a key role in restructuring the large, 60S subunit prior to transport and factors that facilitate transport itself.
openaire +3 more sources
Eukaryotic ribosome biogenesis at a glance [PDF]
Journal of Cell Science, 2013 Summary Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic cells, ribosome biogenesis requires the coordinated activity of all three RNA polymerases and the orchestrated work of many (>200 ...
Thomson, Emma +2 more
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Eukaryotic Ribosome Biogenesis: The 40S Subunit
Acta Naturae, 2022 The formation of eukaryotic ribosomes is a sequential process of ribosomal precursors maturation in the nucleolus, nucleoplasm, and cytoplasm. Hundreds of ribosomal biogenesis factors ensure the accurate processing and formation of the ribosomal RNAs tertiary structure, and they interact with ribosomal proteins.
Moraleva, A. A. +4 more
openaire +2 more sources
BMC Plant Biology, 2023 Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek +5 more
doaj +1 more source
mBio, 2023 Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins.
Maikke B. Ohlson +8 more
doaj +1 more source
Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli. [PDF]
, 2015 The translational GTPase BipA regulates the expression of virulence and pathogenicity factors in several eubacteria. BipA-dependent expression of virulence factors occurs under starvation conditions, such as encountered during infection of a host.
Blaha, Gregor +4 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Microbial Cell, 2019 The formation of new ribosomes is a fundamental cellular process for each living cell and is tightly interwoven with cell cycle control and proliferation.
Lisa Kofler +2 more
doaj +1 more source