Results 71 to 80 of about 57,712 (282)

Eukaryotic Ribosome Biogenesis: The 40S Subunit

Acta Naturae, 2022
The formation of eukaryotic ribosomes is a sequential process of ribosomal precursors maturation in the nucleolus, nucleoplasm, and cytoplasm. Hundreds of ribosomal biogenesis factors ensure the accurate processing and formation of the ribosomal RNAs tertiary structure, and they interact with ribosomal proteins.
Moraleva, A. A., Deryabin, A. S., Rubtsov, Yu. P., Rubtsova, M. P., Dontsova, O. A.   +4 more
openaire   +2 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Signal transduction in ribosome biogenesis: A recipe to avoid disaster [PDF]

, 2019
Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and, therefore, must be highly regulated in order to avoid unnecessary energy expenditure.
Piazzi M., Bavelloni A., Gallo A., Faenza I., Blalock W. L.   +4 more
core   +2 more sources

Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells. [PDF]

PLoS ONE, 2009
Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity--are the main effectors of this process.
Stéphane Belin, Anne Beghin, Eduardo Solano-Gonzàlez, Laurent Bezin, Stéphanie Brunet-Manquat, Julien Textoris, Anne-Catherine Prats, Hichem C Mertani, Charles Dumontet, Jean-Jacques Diaz   +9 more
doaj   +1 more source

Pipeline to quantify ribosome biogenesis activity

, 2023
Pipeline to quantify ribosome biogenesis activity based on transcriptome expression ...
Huajing Teng (17220052)
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus. [PDF]

PLoS Genetics, 2015
The production of ribosomes is ubiquitous and fundamental to life. As such, it is surprising that defects in ribosome biogenesis underlie a growing number of symptomatically distinct inherited disorders, collectively called ribosomopathies. We previously
John N Griffin, Samuel B Sondalle, Florencia Del Viso, Susan J Baserga, Mustafa K Khokha   +4 more
doaj   +1 more source

Structure and dynamics of bacterial ribosome biogenesis [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
Bacterial ribosome biogenesis has been an active area of research for more than 30 years and has served as a test-bed for the development of new biochemical, biophysical and structural techniques to understand macromolecular assembly generally.
Joseph H. Davis, James R. Williamson
openaire   +2 more sources

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

The toxin GraT inhibits ribosome biogenesis [PDF]

Molecular Microbiology, 2016
SummaryMost bacteria encode numerous chromosomal toxin–antitoxin (TA) systems that are proposed to contribute to stress tolerance, as they are able to shift the cells to a dormant state. Toxins act on a variety of targets with the majority attacking the translational apparatus.
Andres, Ainelo, Hedvig, Tamman, Margus, Leppik, Jaanus, Remme, Rita, Hõrak   +4 more
openaire   +2 more sources