Results 61 to 70 of about 57,712 (282)

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) remains one of the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options.
Camille Jouines, Piero Lo Monaco, Angéline Gaucherot, Julie Radermecker, Caroline Isaac, Fleur Bourdelais, Marie-Ambre Monet, Marion Meyer, Mounira Chalabi-Dchar, Flora Nguyen Van Long, Laury Baillon, Carine Froment, Julien Marcoux, Christophe Vanbelle, Tanguy Fenouil, Sébastien Durand, Stéphane Giraud, Jean-Jacques Diaz, Virginie Marcel, Frédéric Catez   +19 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why

Journal of Hematology & Oncology, 2018
It is well known that chemotherapy can cure only some cancers in advanced stage, mostly those with an intact p53 pathway. Hematological cancers such as lymphoma and certain forms of leukemia are paradigmatic examples of such scenario.
Enrico Derenzini, Alessandra Rossi, Davide Treré   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.

PLoS ONE
Chronic kidney disease (CKD) is a global health issue that significantly threatens human health, with its incidence increasing annually. Renal fibrosis is characterized by the progressive loss of kidney function, leading to significant morbidity and ...
Xiaoming Liu, Huijuan Wang, Kai Wang, Ying Liu   +3 more
doaj   +1 more source

The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish

Frontiers in Cell and Developmental Biology, 2021
Ribosome biogenesis is a fundamental activity in cells. Ribosomal dysfunction underlies a category of diseases called ribosomopathies in humans. The symptomatic characteristics of ribosomopathies often include abnormalities in craniofacial skeletons ...
Chong Zhang, Rui Huang, Xirui Ma, Jiehui Chen, Xinlu Han, Li Li, Lingfei Luo, Hua Ruan, Honghui Huang   +8 more
doaj   +1 more source

Ribosomal RNA Processing and Ribosome Biogenesis in Eukaryotes [PDF]

IUBMB Life, 2004
AbstractIn eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans‐acting factors contribute to ribosome biogenesis. After more than 30 years of intense research, the incredible complexities of nucleolar function are revealed but details often remain unclear. Here we review this progress and the many intriguing questions which remain.
openaire   +2 more sources

RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components [PDF]

, 2004
Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome. We
Granneman, Sander; id_orcid, Baserga, Susan J, Gallagher, Jennifer E G, Mitchell, Brianna M, Dunbar, David A, Osheim, Yvonne, Beyer, Ann L   +6 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The Circadian Clock Coordinates Ribosome Biogenesis

PLoS Biology, 2013
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators.
Jouffe, Celine, Cretenet, Gaspard, Symul, Laura, Martin, Eva, Atger, Florian, Naef, Felix, Gachon, Frederic   +6 more
openaire   +9 more sources