Results 31 to 40 of about 57,712 (282)

Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes

Plants, 2020
Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino, Michal Gorka, Alexander Graf, Aleksandra Skirycz, Federico Martinez-Seidel, Kerstin Zander, Joachim Kopka, Olga Beine-Golovchuk   +7 more
doaj   +1 more source

Does the blunted stimulation of skeletal muscle protein synthesis by aging in response to mechanical load result from impaired ribosome biogenesis?

Frontiers in Aging, 2023
Age-related loss of skeletal muscle mass leads to a reduction of strength. It is likely due to an inadequate stimulation of muscle protein synthesis (MPS) in response to anabolic stimuli, such as mechanical load.
Thomas Chaillou, Diego Montiel-Rojas
doaj   +1 more source

Disruption of ribosome biogenesis triggers a p21/p53-mediated cell cycle checkpoint [PDF]

, 2006
Cell cycle entry requires a dramatic increase in protein production. In order to cope with this demand, the cell must upregulate ribosome biogenesis. Given that ribosome biogenesis is the most energy-consuming anabolic process in a growing cell, and ...
Di Cara, Alessandro
core   +1 more source

Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways

Open Biology, 2022
Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of function in the translation machinery components results in
Agustian Surya, Elif Sarinay-Cenik
doaj   +1 more source

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

Cell Reports, 2015
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process.
Lukas Badertscher, Thomas Wild, Christian Montellese, Leila T. Alexander, Lukas Bammert, Marie Sarazova, Michael Stebler, Gabor Csucs, Thomas U. Mayer, Nicola Zamboni, Ivo Zemp, Peter Horvath, Ulrike Kutay   +12 more
doaj   +1 more source

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]

, 2008
In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Martin Kos, Markus T Bohnsack, Bohnsack, Markus T., Tollervey, David, David Tollervey, Kos, Martin, Bohnsack, Markus   +6 more
core   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C., Taylor, Peter M., Liu, R., Iadevaia, Valentina, Averous, Julien, Liu, R, Proud, Christopher G., Proud, CG, Taylor, P., Zhang, Z., Taylor, PM, Zhang, Z, Liu, Rui, Iadevaia, V, Zhang, Ze, Averous, J., Averous, J, Iadevaia, V.   +17 more
core   +1 more source

Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion [PDF]

, 2023
Cancer cells are especially sensitive to perturbations in ribosome biogenesis as they rely on finely tuned protein homeostasis to facilitate their rapid growth and proliferation.
Zhang, Yinfeng, Yang, Naiheng J, Scull, Catherine E, Hunter, Robert N, David A. Schneider, Augelli-Szafran, Corinne E, Twa, Guy, Guy Twa, Schneider, David A, Naiheng J. Yang, Yinfeng Zhang, Catherine E. Scull, Robert N. Hunter, Corinne E. Augelli-Szafran   +13 more
core   +1 more source

The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14 [PDF]

, 2005
One of the proteins identified as being involved in ribosome biogenesis by high-throughput studies, a putative P-loop-type kinase termed Fap7 (YDL166c), was shown to be required for the conversion of 20S pre-rRNA to 18S rRNA.
Nandineni, Madhusudan R, Granneman, Sander; id_orcid, Baserga, Susan J   +2 more
core   +1 more source

Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients.

PLoS ONE, 2017
Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification.
Virginie Marcel, Frédéric Catez, Caroline M Berger, Emeline Perrial, Adriana Plesa, Xavier Thomas, Eve Mattei, Sandrine Hayette, Pierre Saintigny, Philippe Bouvet, Jean-Jacques Diaz, Charles Dumontet   +11 more
doaj   +1 more source