Results 11 to 20 of about 57,712 (282)
G-patch proteins: important regulators of pre-mRNA splicing and ribosome biogenesis [PDF]
Frontiers in Cell and Developmental BiologyPre-mRNA splicing is a fundamental step in eukaryotic gene expression, carried out by the spliceosome. This large and dynamic ribonucleoprotein complex undergoes extensive structural rearrangements during each splicing event.
Laura Olivia Karika +3 more
doaj +2 more sources
Ribosome biogenesis: A central player in liver diseases [PDF]
Genes and DiseasesRibosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo +3 more
doaj +2 more sources
Elucidating AML ribosome biogenesis reshaping prognostic assessment and immune microenvironment integrated single-cell and bulk RNA analysis [PDF]
Frontiers in ImmunologyBackgroundAcute Myeloid Leukemia (AML) is an aggressive hematologic malignancy with significant clinical challenges due to its heterogeneity and high relapse rate.
Xiaohe Chen +4 more
doaj +2 more sources
Regulation of ribosome biogenesis within the nucleolus
FEBS Letters, 2001 Ribosome biogenesis is both necessary for cellular adaptation, growth, and proliferation as well as a major energetic and biosynthetic demand upon cells. For these reasons, ribosome biogenesis requires precise regulation to balance supply and demand. The complexity of ribosome biogenesis gives rise to many steps and opportunities where regulation could
Leary, Daniel J, Huang, Sui
openaire +3 more sources
Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number
Cell Reports, 2018 Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain ...
Katherine I Farley-Barnes +2 more
exaly +3 more sources
, 2022 This Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic.
core +4 more sources
FOSL1 promotes homologous recombination repair and camptothecin resistance via TCOF1-mediated ribosome biogenesis in non-small cell lung cancer [PDF]
Translational OncologyBackground: Camptothecin (CPT) and its derivatives are important chemotherapeutic agents; however, intrinsic and acquired tolerance frequently limits their long-term efficacy.
Chunmei Hao +5 more
doaj +2 more sources
Downregulation of ribosome biogenesis during early forebrain development
eLife, 2018 Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs.
Kevin F Chau +9 more
doaj +2 more sources
PLoS Biology, 2023 Interorgan communication is crucial for multicellular organismal growth, development, and homeostasis. Cell nonautonomous inhibitory cues, which limit tissue-specific growth alterations, are not well characterized due to cell ablation approach ...
Qiuxia Zhao +4 more
doaj +1 more source
Nature Communications, 2023 Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig +14 more
doaj +1 more source