Ribosome Biogenesis in Archaea [PDF]
Frontiers in Microbiology, 2021 Making ribosomes is a major cellular process essential for the maintenance of functional ribosome homeostasis and to ensure appropriate gene expression.
Paola Londei, Sébastien Ferreira-Cerca
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Ribosome Biogenesis Alterations in Colorectal Cancer [PDF]
Cells, 2020 Many studies have focused on understanding the regulation and functions of aberrant protein synthesis in colorectal cancer (CRC), leaving the ribosome, its main effector, relatively underappreciated in CRC.
Sophie Nait Slimane +7 more
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Ribosome biogenesis: A central player in liver diseases. [PDF]
Genes DisRibosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Luo W, Zhou J, Yan Y, Xu X.
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Elucidating AML ribosome biogenesis reshaping prognostic assessment and immune microenvironment integrated single-cell and bulk RNA analysis. [PDF]
Front ImmunolBackgroundAcute Myeloid Leukemia (AML) is an aggressive hematologic malignancy with significant clinical challenges due to its heterogeneity and high relapse rate.
Chen X, Feng A, Chen F, Zeng J, Chen M.
europepmc +2 more sources
Ribosome biogenesis factors—from names to functions
EMBO Journal, 2023 AbstractThe assembly of ribosomal subunits is a highly orchestrated process that involves a huge cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles in Saccharomyces cerevisiae.
Chiara Ruggeri, Ivo Zemp, Ulrike Kutay
exaly +4 more sources
RNase III, Ribosome Biogenesis and Beyond [PDF]
Microorganisms, 2021 The ribosome is the universal catalyst for protein synthesis. Despite extensive studies, the diversity of structures and functions of this ribonucleoprotein is yet to be fully understood.
Maxence Lejars +2 more
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FOSL1 promotes homologous recombination repair and camptothecin resistance via TCOF1-mediated ribosome biogenesis in non-small cell lung cancer. [PDF]
Transl OncolBackground: Camptothecin (CPT) and its derivatives are important chemotherapeutic agents; however, intrinsic and acquired tolerance frequently limits their long-term efficacy.
Hao C +5 more
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Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis. [PDF]
PLoS OneChronic kidney disease (CKD) is a global health issue that significantly threatens human health, with its incidence increasing annually. Renal fibrosis is characterized by the progressive loss of kidney function, leading to significant morbidity and ...
Liu X, Wang H, Wang K, Liu Y.
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Autonomous ribosome biogenesis in vitro. [PDF]
Nat CommunRibosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Kosaka Y +14 more
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Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number
Cell Reports, 2018 Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain ...
Katherine I. Farley-Barnes +5 more
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