Results 21 to 30 of about 142,894 (282)

Tracing Eukaryotic Ribosome Biogenesis Factors Into the Archaeal Domain Sheds Light on the Evolution of Functional Complexity

Frontiers in Microbiology, 2021
Ribosome assembly is an essential and carefully choreographed cellular process. In eukaryotes, several 100 proteins, distributed across the nucleolus, nucleus, and cytoplasm, co-ordinate the step-wise assembly of four ribosomal RNAs (rRNAs) and ...
Mehmet Birikmen, Katherine E. Bohnsack, Vinh Tran, Sharvari Somayaji, Markus T. Bohnsack, Markus T. Bohnsack, Ingo Ebersberger, Ingo Ebersberger, Ingo Ebersberger   +8 more
doaj   +1 more source

Peptides Targeting the Interaction Between Erb1 and Ytm1 Ribosome Assembly Factors

Frontiers in Molecular Biosciences, 2021
Ribosome biogenesis is an emerging therapeutic target. It has been proposed that cancer cells are addicted to ribosome production which is therefore considered a druggable pathway in cancer therapy.
Lidia Orea-Ordóñez, Susana Masiá, Jerónimo Bravo   +2 more
doaj   +1 more source

Translational GTPase BipA Is Involved in the Maturation of a Large Subunit of Bacterial Ribosome at Suboptimal Temperature

Frontiers in Microbiology, 2021
BPI-inducible protein A (BipA), a highly conserved paralog of the well-known translational GTPases LepA and EF-G, has been implicated in bacterial motility, cold shock, stress response, biofilm formation, and virulence.
Kwok Jian Goh, Rya Ero, Xin-Fu Yan, Jung-Eun Park, Binu Kundukad, Jun Zheng, Siu Kwan Sze, Yong-Gui Gao   +7 more
doaj   +1 more source

40S ribosome biogenesis co-factors are essential for gametophyte and embryo development [PDF]

, 2013
Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Roman Martin, Martin, Roman, Roman Martin (85483), Simm, Stefan, Markus T. Bohnsack, Markus T Bohnsack, Benjamin L. Weis (277837), Stefan Simm, Sandra Missbach (277836), Markus T. Bohnsack (277840), Benjamin L Weis, Enrico Schleiff, Weis, Benjamin L., Sandra Missbach, Bohnsack, Markus, Mißbach, Sandra, Stefan Simm (277838), Schleiff, Enrico, Enrico Schleiff (49377), Lafontaine, Denis, Bohnsack, Markus T., Ra Missbach, Benjamin L. Weis   +22 more
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Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer

BMC Cancer, 2022
Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. Thus, ribosome
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel   +30 more
doaj   +1 more source

The small-subunit processome is a ribosome assembly intermediate [PDF]

, 2004
The small-subunit (SSU) processome is a large ribonucleoprotein required for the biogenesis of the 18S rRNA and likely corresponds to the terminal knobs visualized by electron microscopy on the 5' end of nascent rRNAs.
Granneman, Sander; id_orcid, Baserga, Susan J, Gallagher, Jennifer E G, Mitchell, Brianna M, Bernstein, Kara A   +4 more
core   +1 more source

Post-transcriptional regulation of ribosome biogenesis in yeast [PDF]

, 2017
Most microorganisms are exposed to the constantly and often rapidly changing environment. As such they evolved mechanisms to balance their metabolism and energy expenditure with the resources available to them.
Martin Koš, Isabelle C. Kos-Braun
core   +1 more source

Does the blunted stimulation of skeletal muscle protein synthesis by aging in response to mechanical load result from impaired ribosome biogenesis?

Frontiers in Aging, 2023
Age-related loss of skeletal muscle mass leads to a reduction of strength. It is likely due to an inadequate stimulation of muscle protein synthesis (MPS) in response to anabolic stimuli, such as mechanical load.
Thomas Chaillou, Diego Montiel-Rojas
doaj   +1 more source

Disruption of ribosome biogenesis triggers a p21/p53-mediated cell cycle checkpoint [PDF]

, 2006
Cell cycle entry requires a dramatic increase in protein production. In order to cope with this demand, the cell must upregulate ribosome biogenesis. Given that ribosome biogenesis is the most energy-consuming anabolic process in a growing cell, and ...
Di Cara, Alessandro
core   +1 more source

Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes

Plants, 2020
Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino, Michal Gorka, Alexander Graf, Aleksandra Skirycz, Federico Martinez-Seidel, Kerstin Zander, Joachim Kopka, Olga Beine-Golovchuk   +7 more
doaj   +1 more source