Results 41 to 50 of about 14,550 (176)

A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer

Cell Reports, 2017
Summary: Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important roles in tumorigenesis. We systematically investigated the expression landscape and clinical relevance of snoRNAs in >10,000 samples across 31 cancer types ...
Jing Gong, Yajuan Li, Chun-jie Liu, Yu Xiang, Chunlai Li, Youqiong Ye, Zhao Zhang, David H. Hawke, Peter K. Park, Lixia Diao, John A. Putkey, Liuqing Yang, An-Yuan Guo, Chunru Lin, Leng Han   +14 more
doaj   +1 more source

Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types

Cells, 2020
Small nucleolar RNAs (snoRNAs) are non-coding RNAs involved in RNA modification and processing. Approximately half of the so far identified snoRNA genes map within the intronic regions of host genes, and their expression, as well as the expression of ...
Marianna Penzo, Rosanna Clima, Davide Trerè, Lorenzo Montanaro   +3 more
doaj   +1 more source

snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs [PDF]

Nucleic Acids Research, 2006
The snoRNA-LBME-db is a dedicated database containing human C/D box and H/ACA box small nucleolar RNAs (snoRNAs), and small Cajal body-specific RNAs (scaRNAs). C/D box and H/ACA box snoRNAs are part of ribonucleoparticles that guide 2'-O-ribose methylation and pseudouridilation, respectively, of selected residues of 28S, 18S or 5.8S rRNAs or of the ...
Lestrade, Laurent, Weber, Michel J.
openaire   +2 more sources

Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome

Microbial Cell
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precur-sor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3-end mat-uration are subject to an active degradation by Rrp6p and Rrp47p, which does not require the ...
Anusha Chaudhuri, Soumita Paul, Mayukh Banerjea, Biswadip Das   +3 more
doaj   +1 more source

A prognostic signature based on snoRNA predicts the overall survival of lower-grade glioma patients

Frontiers in Immunology, 2023
IntroductionSmall nucleolar RNAs (snoRNAs) are a group of non-coding RNAs enriched in the nucleus which direct post-transcriptional modifications of rRNAs, snRNAs and other molecules.
Yi Zhou, Yi Zhou, Wen Yin, Wen Yin, Yirui Kuang, Yirui Kuang, Zhaoping Wu, Zhaoping Wu, Haoxuan Huang, Haoxuan Huang, Weidong Liu, Weidong Liu, Weidong Liu, Weidong Liu, Xingjun Jiang, Xingjun Jiang, Caiping Ren, Caiping Ren, Caiping Ren, Caiping Ren   +19 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis

Cell Death and Disease
U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome passenger.
Yang Jiang, Shiqi Sun, Xiaofeng Liu, Kunqi Su, Chunfeng Zhang, Peipei Zhang, Zhuochen Zhao, Ya Su, Chang Wang, Xiaojuan Du   +9 more
doaj   +1 more source

The genetic and pharmacogenomic landscape of snoRNAs in human cancer

Molecular Cancer, 2020
Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized.
Yaoming Liu, Hang Ruan, Shengli Li, Youqiong Ye, Wei Hong, Jing Gong, Zhao Zhang, Ying Jing, Xiulan Zhang, Lixia Diao, Leng Han   +10 more
doaj   +1 more source

Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs

Non-Coding RNA, 2021
Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation of ribosomal RNA in Archaea and Eukaryotes.
Laeya Baldini, Bruno Charpentier, Stéphane Labialle   +2 more
doaj   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source