Results 51 to 60 of about 15,041 (173)

Phylogenetic distribution of plant snoRNA families

BMC Genomics, 2016
Small nucleolar RNAs (snoRNAs) are one of the most ancient families amongst non-protein-coding RNAs. They are ubiquitous in Archaea and Eukarya but absent in bacteria. Their main function is to target chemical modifications of ribosomal RNAs. They fall into two classes, box C/D snoRNAs and box H/ACA snoRNAs, which are clearly distinguished by conserved
Deblina Patra Bhattacharya, Sebastian Canzler, Stephanie Kehr, Jana Hertel, Ivo Grosse, Peter F. Stadler   +5 more
openaire   +5 more sources

Distinct Pathways for snoRNA and mRNA Termination [PDF]

Molecular Cell, 2006
Transcription termination at mRNA genes is linked to polyadenylation. Cleavage at the poly(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the downstream transcript to promote termination. Small nucleolar RNAs (snoRNAs) are also transcribed by RNA polymerase II but are not polyadenylated.
Kim, Minkyu, Vasiljeva, Lidia, Rando, Oliver J., Zhelkovsky, Alexander, Moore, Claire, Buratowski, Stephen   +5 more
openaire   +2 more sources

U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis

Cell Death and Disease
U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome passenger.
Yang Jiang, Shiqi Sun, Xiaofeng Liu, Kunqi Su, Chunfeng Zhang, Peipei Zhang, Zhuochen Zhao, Ya Su, Chang Wang, Xiaojuan Du   +9 more
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors [PDF]

Molecular Biology of the Cell, 2010
Human small nucleolar RNAs (snoRNAs) that copurify with nucleoli isolated from HeLa cells have been characterized. Novel fibrillarin-associated snoRNAs were detected that allowed the creation of a new vector system for the targeted knockdown of one or more genes in mammalian cells.
Ono, Motoharu, Yamada, Kayo, Avolio, Fabio, Scott, Michelle S., van Koningsbruggen, Silvana, Barton, Geoffrey J., Lamond, Angus I.   +6 more
openaire   +3 more sources

Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome

Microbial Cell
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precur-sor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3-end mat-uration are subject to an active degradation by Rrp6p and Rrp47p, which does not require the ...
Anusha Chaudhuri, Soumita Paul, Mayukh Banerjea, Biswadip Das   +3 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

The genetic and pharmacogenomic landscape of snoRNAs in human cancer

Molecular Cancer, 2020
Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized.
Yaoming Liu, Hang Ruan, Shengli Li, Youqiong Ye, Wei Hong, Jing Gong, Zhao Zhang, Ying Jing, Xiulan Zhang, Lixia Diao, Leng Han   +10 more
doaj   +1 more source

A prognostic signature based on snoRNA predicts the overall survival of lower-grade glioma patients

Frontiers in Immunology, 2023
IntroductionSmall nucleolar RNAs (snoRNAs) are a group of non-coding RNAs enriched in the nucleus which direct post-transcriptional modifications of rRNAs, snRNAs and other molecules.
Yi Zhou, Yi Zhou, Wen Yin, Wen Yin, Yirui Kuang, Yirui Kuang, Zhaoping Wu, Zhaoping Wu, Haoxuan Huang, Haoxuan Huang, Weidong Liu, Weidong Liu, Weidong Liu, Weidong Liu, Xingjun Jiang, Xingjun Jiang, Caiping Ren, Caiping Ren, Caiping Ren, Caiping Ren   +19 more
doaj   +1 more source