Results 31 to 40 of about 15,041 (173)
The emerging role of snoRNAs in human disease
Genes & Diseases, 2023 Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The aberrant expression or depletion of snoRNAs is related to various diseases. In previous research, most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs, whose typical functions were thought of as regulation of 2'-O-ribose methylation and ...
Xinhai Zhang +8 more
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The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis. [PDF]
Biol CellWe highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Fraboulet S, Aldarawish O, Dolega ME.
europepmc +2 more sources
Mapping targets for small nucleolar RNAs in yeast [version 2; referees: 5 approved]
Wellcome Open Research, 2018 Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding ...
Tatiana Dudnakova +3 more
doaj +1 more source
Animal snoRNAs and scaRNAs with exceptional structures [PDF]
RNA Biology, 2011 The overwhelming majority of small nucleolar RNAs (snoRNAs) fall into two clearly defined classes characterized by distinctive secondary structures and sequence motifs. A small group of diverse ncRNAs, however, shares the hallmarks of one or both classes of snoRNAs but differs substantially from the norm in some respects.
Manja, Marz +14 more
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Mapping targets for small nucleolar RNAs in yeast [version 1; referees: 3 approved]
Wellcome Open Research, 2018 Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D snoRNAs in budding ...
Tatiana Dudnakova +3 more
doaj +1 more source
snoStrip: a snoRNA annotation pipeline
Bioinformatics, 2013 Abstract Motivation: Although small nucleolar RNAs form an important class of non-coding RNAs, no comprehensive annotation efforts have been undertaken, presumably because the task is complicated by both the large number of distinct small nucleolar RNA families and their relatively rapid pace of sequence evolution. Results:
Sebastian Bartschat +4 more
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Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies
Non-Coding RNA, 2021 Over recent years, the long known class of small nucleolar RNAs (snoRNAs) have gained interest among the scientific community, especially in the clinical context.
Jaime Calvo Sánchez, Marcel Köhn
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Small RNAs derived from snoRNAs [PDF]
RNA, 2009 Small nucleolar RNAs (snoRNAs) guide RNA modification and are localized in nucleoli and Cajal bodies in eukaryotic cells. Components of the RNA silencing pathway associate with these structures, and two recent reports have revealed that a human and a protozoan snoRNA can be processed into miRNA-like RNAs.
Taft, Ryan J. +5 more
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Human miRNA precursors with box H/ACA snoRNA features.
PLoS Computational Biology, 2009 MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years.
Michelle S Scott +4 more
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Maturation of small nucleolar RNAs: from production to function
RNA Biology, 2023 Small Nucleolar RNAs (snoRNAs) are an abundant group of non-coding RNAs with well-defined roles in ribosomal RNA processing, folding and chemical modification.
Sarah F. Webster, Homa Ghalei
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