Results 31 to 40 of about 3,085 (163)

A Pseudouridine Residue in the Spliceosome Core Is Part of the Filamentous Growth Program in Yeast

Cell Reports, 2014
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), they are not known to have physiologic roles in cell differentiation.
Anindita Basak, Charles C. Query
doaj   +1 more source

Pseudouridine Synthase RsuA Confers a Survival Advantage to Bacteria under Streptomycin Stress

Antibiotics, 2023
Bacterial ribosome small subunit rRNA (16S rRNA) contains 11 nucleotide modifications scattered throughout all its domains. The 16S rRNA pseudouridylation enzyme, RsuA, which modifies U516, is a survival protein essential for bacterial survival under ...
Sudeshi M. Abedeera, Kumudie S. Jayalath, Jiale Xie, Rushdhi M. Rauff, Sanjaya C. Abeysirigunawardena   +4 more
doaj   +1 more source

The impact of scaRNA12 deregulation on p53-mediated cellular stress response in B-cell precursor acute lymphoblastic leukaemia. [PDF]

Br J Haematol
Summary Small nucleolar ribonucleic acids (snoRNAs) are a class of small non‐coding RNAs involved in the post‐transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) is ...
Verbeek MWC, Sanders MA, Grashof DGB, Hoogenboezem RM, van Zuijen I, Bos A, van Gulck T, Olsman R, Mukhopadhyay R, Bindels EMJ, Valk PJM, van de Werken HJG, van der Velden VHJ, Erkeland SJ.   +13 more
europepmc   +2 more sources

Dyskerin Mutations Present in Dyskeratosis Congenita Patients Increase Oxidative Stress and DNA Damage Signalling in Dictyostelium Discoideum

Cells, 2019
Dyskerin is a protein involved in the formation of small nucleolar and small Cajal body ribonucleoproteins. These complexes participate in RNA pseudouridylation and are also components of the telomerase complex required for telomere elongation.
Javier Rodriguez-Centeno, Rosario Perona, Leandro Sastre   +2 more
doaj   +1 more source

FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications

Scientific Reports, 2023
FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression.
Kishor Gawade, Patrycja Plewka, Sophia J. Häfner, Anders H. Lund, Virginie Marchand, Yuri Motorin, Michal W. Szczesniak, Katarzyna D. Raczynska   +7 more
doaj   +1 more source

Regulation and Function of RNA Pseudouridylation in Human Cells

Annual Review of Genetics, 2020
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conformations and destabilizing interactions with varied RNA-binding proteins, suggest that RNA ...
Erin K, Borchardt, Nicole M, Martinez, Wendy V, Gilbert   +2 more
openaire   +3 more sources

RNA pseudouridylation: new insights into an old modification [PDF]

Trends in Biochemical Sciences, 2013
Pseudouridine is the most abundant post-transcriptionally modified nucleotide in various stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific isomerization, resulting in an extra hydrogen-bond donor that distinguishes it from other nucleotides. In eukaryotes, uridine-to-pseudouridine isomerization is catalyzed primarily
Junhui, Ge, Yi-Tao, Yu
openaire   +2 more sources

RNA-guided isomerization of uridine to pseudouridine—pseudouridylation [PDF]

RNA Biology, 2014
Box H/ACA ribonucleoproteins (RNPs), each consisting of one unique guide RNA and 4 common core proteins, constitute a family of complex enzymes that catalyze, in an RNA-guided manner, the isomerization of uridines to pseudouridines (Ψs) in RNAs, a reaction known as pseudouridylation.
Yi-Tao, Yu, U Thomas, Meier
openaire   +2 more sources

Pseudouridylation of yeast ribosomal precursor RNA

Nucleic Acids Research, 1979
The pseudouridylation of ribosomal RNA of Saccharomyces carlsbergensis was investigated with respect to its timing during the maturation of rRNA and its sequence specificity. Analysis of 37-S RNA, the common precursor to 17-S, 5.8-S and 26-S rRNA and most probably the primary ribosomal transcript, shows that this RNA molecule contains already most if ...
R. C. Brand, J. Klootwijk, C. P. Sibum, R. Planta   +3 more
openaire   +4 more sources

Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation

iScience
Summary: Pseudouridylation plays a regulatory role in various physiological and pathological processes. A prime example is the mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome (MLASA), characterized by defective ...
Deyang Shi, Bichen Wang, Haoyuan Li, Yu Lian, Qiuyi Ma, Tong Liu, Mutian Cao, Yuanwu Ma, Lei Shi, Weiping Yuan, Jun Shi, Yajing Chu   +11 more
doaj   +1 more source