Results 11 to 20 of about 3,085 (163)

Mechanistic insight into the pseudouridylation of RNA [PDF]

RNA Biology
Pseudouridylation (Ψ) is a highly abundant and conserved RNA modification that is present in all three domains of life. The incorporation of Ψ can affect the stability of RNAs, modulate their interaction patterns, and regulate many other aspects of RNA ...
Ting-Yu Lin, Yasmin Stone, Sebastian Glatt   +2 more
doaj   +6 more sources

Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2022
Pseudouridine (Psi) is one of the most frequent post-transcriptional modification of RNA. Enzymatic Psi modification occurs on rRNA, snRNA, snoRNA, tRNA, and non-coding RNA and has recently been discovered on mRNA.
Wan Song, Ram Podicheti, Douglas B Rusch, William Daniel Tracey   +3 more
doaj   +3 more sources

DKC1: a robust prognostic factor and potential therapeutic target in multiple myeloma [PDF]

Journal of Translational Medicine
Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Dyskerin pseudouridine synthase 1 (DKC1), a nucleolar protein, is essential for RNA modification and cellular homeostasis, yet its role in MM remains unclear.
Chenxi Sun, Lin Cheng, Ai Li, Yanxiao Han, Yongjing Wang, Juan Xiao, Yanan Guo, Wenting Zhang, Likun Sun, Dawei Xu, Dexiao Kong, Yang Jiang, Chengyun Zheng   +12 more
doaj   +2 more sources

Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance [PDF]

Nature Communications
Pseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It is widely speculated that Ψ inclusion in messenger RNAs (mRNAs) might provide an avenue for cells to control gene expression post-transcriptionally ...
Minli Ruan, Sean M. Engels, Matthew R. Burroughs, Xiaoyan Li, Rosella Stower, Talia Tzadikario, Connor Powell, Dylan Bloch, Oleksandra Fanari, Stuart Akeson, Daniel E. Eyler, Chase A. Weidmann, Sara Rouhanifard, Miten Jain, Lydia M. Contreras, Kristin S. Koutmou   +15 more
doaj   +2 more sources

Ribosomal RNA Pseudouridylation: Will Newly Available Methods Finally Define the Contribution of This Modification to Human Ribosome Plasticity?

Frontiers in Genetics, 2022
In human rRNA, at least 104 specific uridine residues are modified to pseudouridine. Many of these pseudouridylation sites are located within functionally important ribosomal domains and can influence ribosomal functional features.
Chiara Barozzi, Chiara Barozzi, Federico Zacchini, Federico Zacchini, Sidra Asghar, Sidra Asghar, Lorenzo Montanaro, Lorenzo Montanaro, Lorenzo Montanaro   +8 more
doaj   +1 more source

Transcriptome-wide mapping of pseudouridines: pseudouridine synthases modify specific mRNAs in S. cerevisiae. [PDF]

PLoS ONE, 2014
We developed a novel technique, called pseudouridine site identification sequencing (PSI-seq), for the transcriptome-wide mapping of pseudouridylation sites with single-base resolution from cellular RNAs based on the induced termination of reverse ...
Alexander F Lovejoy, Daniel P Riordan, Patrick O Brown   +2 more
doaj   +1 more source

The Arabidopsis 2′-O-Ribose-Methylation and Pseudouridylation Landscape of rRNA in Comparison to Human and Yeast

Frontiers in Plant Science, 2021
Eukaryotic ribosome assembly starts in the nucleolus, where the ribosomal DNA (rDNA) is transcribed into the 35S pre-ribosomal RNA (pre-rRNA). More than two-hundred ribosome biogenesis factors (RBFs) and more than two-hundred small nucleolar RNAs (snoRNA)
Deniz Streit, Enrico Schleiff, Enrico Schleiff   +2 more
doaj   +1 more source

From Antisense RNA to RNA Modification: Therapeutic Potential of RNA-Based Technologies

Biomedicines, 2021
Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity, affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or mRNA translation.
Hironori Adachi, Martin Hengesbach, Yi-Tao Yu, Pedro Morais   +3 more
doaj   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients. [PDF]

Clin Genet
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Bergès C, Sauvestre C, Naudion S, Delorme CV, Smol T, Rama M, Moortgat S, Maystadt I, Kersseboom R, Wilke M, Barakat TS, Vial Y, Perrin L, Passemard S, Ahmad F, Umair M, Haack T, Grimmel M, Kuechler A, Slavotinek A, Devine P, Hodoglugil U, Zafar F, Afzal E, Dudding-Byth T, Jouret G, Herissant L, Efthymiou S, Houlden H, Legendre M, Michaud V.   +30 more
europepmc   +2 more sources

Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity [PDF]

Genes & Development, 2021
Site-specific pseudouridylation of human ribosomal and spliceosomal RNAs is directed by H/ACA guide RNAs composed of two hairpins carrying internal pseudouridylation guide loops. The distal “antisense” sequences of the pseudouridylation loop base-pair with the target RNA to position two unpaired target nucleotides 5′-UN-3′, including the 5′ substrate U,
Beáta E. Jády, Amandine Ketele, Dylan Moulis, Tamás Kiss   +3 more
openaire   +3 more sources