Results 41 to 50 of about 3,085 (163)

Control of protein synthesis through mRNA pseudouridylation by dyskerin

Science Advances, 2023
Posttranscriptional modifications of mRNA have emerged as regulators of gene expression. Although pseudouridylation is the most abundant, its biological role remains poorly understood. Here, we demonstrate that the pseudouridine synthase dyskerin associates with RNA polymerase II, binds to thousands of mRNAs, and is responsible for their ...
Chiara Pederiva, Davide M. Trevisan, Dimitra Peirasmaki, Shan Chen, Sharon A. Savage, Ola Larsson, Jernej Ule, Laura Baranello, Federico Agostini, Marianne Farnebo   +9 more
openaire   +2 more sources

Unraveling the mechanisms of pseudouridylation in rice plant immunity: The power of next-generation sequencing

Current Plant Biology
Pseudouridylation is a prevalent RNA modification that plays a pivotal role in regulating gene expression and modulating plant responses to biotic stresses, such as pathogenic attacks.
Misbah Naz, Xiaosi Bu, Muhammad Rahil Afzal, Zhuo Chen   +3 more
doaj   +1 more source

Inhibition of human dyskerin as a new approach to target ribosome biogenesis. [PDF]

PLoS ONE, 2014
The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has been explored for the development of drugs to selectively or preferentially kill cancer cells ...
Laura Rocchi, Arménio J M Barbosa, Carmine Onofrillo, Carmine Onofrillo, Alberto Del Rio, Lorenzo Montanaro   +5 more
doaj   +1 more source

Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis

Nature Cancer, 2021
Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is highly expressed in glioblastoma versus normal brain tissues, and high PUS7 expression levels are associated with worse survival in patients with glioblastoma.
Qi Cui, Kailin Yin, Xiaoting Zhang, Peng Ye, Xianwei Chen, Jianfei Chao, Haowei Meng, Jiangbo Wei, Daniel Roeth, Li Li, Yue Qin, Guihua Sun, Mingzi Zhang, Jeremy Klein, Marvin Huynhle, Cheng Wang, Leying Zhang, Behnam Badie, Markus Kalkum, Chuan He, Chengqi Yi, Yanhong Shi   +21 more
openaire   +3 more sources

Overview on Epstein–Barr Virus–Host Interactions With a Focus on Host Cell Transcriptome Alterations

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT The Epstein–Barr virus (EBV) belongs to the gamma subgroup of human herpesviruses. EBV is particularly lymphotropic regarding its latency, meaning that it preferentially targets lymphocytes as its immunological niche. During the establishment of the complex virus–host relationships, the virus influences the human host cell transcriptome ...
Louise Wallot, Tim Hohmann, Urszula Hohmann, Faramarz Dehghani, Olaf Grisk, Simon Jasinski‐Bergner   +5 more
wiley   +1 more source

How Epitranscriptomic Machinery Senses Environmental Cues

Advanced Biology, Volume 10, Issue 9, September 2026.
Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley   +1 more source

SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation

Journal of Experimental & Clinical Cancer Research, 2023
Background Colorectal cancer (CRC) is one of the most common malignancies and is characterized by reprogrammed metabolism. Ferroptosis, a programmed cell death dependent on iron, has emerged as a promising strategy for CRC treatment.
Chang Xu, Zhixuan Bian, Xinyue Wang, Na Niu, Li Liu, Yixuan Xiao, Jiabei Zhu, Nan Huang, Yue Zhang, Yan Chen, Qi Wu, Fenyong Sun, Xiaoli Zhu, Qiuhui Pan   +13 more
doaj   +1 more source

Epitranscriptomic Regulation of Bone Metabolism: Emerging Roles of N6‐Methyladenosine (m6A) Modification in Skeletal Homeostasis

Oral Science International, Volume 23, Issue 3, September 2026.
ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
wiley   +1 more source

RNA‐Protein Assemblies: A Review of Biophysical Principles and Coarse‐Grained Modeling Approaches

WIREs RNA, Volume 17, Issue 5, September/October 2026.
RNA‐protein assemblies in the nucleolus, nuclear speckles, and viral ribonucleoprotein complexes are governed by multivalent IDR‐RNA interactions that drive liquid–liquid phase separation. This review examines the molecular grammar underlying these systems and critically evaluates coarse‐grained computational frameworks for modeling their sequence ...
Muhammad Waleed Iqbal, Patrick R. Onck
wiley   +1 more source

Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation

World Journal of Biological Chemistry, 2014
Pseudouridines (Ψs) are the most abundant and highly conserved modified nucleotides found in various stable RNAs of all organisms. Most Ψs are clustered in regions that are functionally important for pre-mRNA splicing. Ψ has an extra hydrogen bond donor that endows RNA molecules with distinct properties that contribute significantly to RNA-mediated ...
Hironori, Adachi, Yi-Tao, Yu
openaire   +2 more sources