Results 51 to 60 of about 3,085 (163)

Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies

Frontiers in Oncology, 2022
Small nucleolar RNAs (snoRNAs) belong to a family of noncoding RNAs that are 60-300 nucleotides in length, and they are classified into two classes according to their structure and function: C/D box snoRNAs, playing an essential role in 2’-O-methylation ...
Jian Dong, Jian Dong, Jian Dong, Hui Wang, Hui Wang, Hui Wang, Zhaoru Zhang, Zhaoru Zhang, Zhaoru Zhang, Lin Yang, Lin Yang, Lin Yang, Xinyue Qian, Xinyue Qian, Xinyue Qian, Wenchang Qian, Wenchang Qian, Wenchang Qian, Yingli Han, Yingli Han, Yingli Han, He Huang, He Huang, He Huang, Pengxu Qian, Pengxu Qian, Pengxu Qian   +26 more
doaj   +1 more source

Alterations of ribosomal RNA pseudouridylation in human breast cancer

NAR Cancer, 2023
Abstract RNA modifications are key regulatory factors for several biological and pathological processes. They are abundantly represented on ribosomal RNA (rRNA), where they contribute to regulate ribosomal function in mRNA translation. Altered RNA modification pathways have been linked to tumorigenesis as well as to other human diseases.
Barozzi C., Zacchini F., Corradini A. G., Morara M., Serra M., De Sanctis V., Bertorelli R., Dassi E., Montanaro L.   +8 more
openaire   +3 more sources

N‐Terminal Variant p.Ala2Val in X‐Linked Dyskeratosis Congenita Gene (DKC1) Disrupts Its Post‐Translational Modification and Nucleolar Localization

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Major symptoms of dyskeratosis congenita. Predicted nuclear localization site at N‐terminus of DKC1 protein. Comparison of nuclear localization for DKC1 showing normal localization for wild‐type versus disruption of localization for p.Ala2Val. ABSTRACT Background Dyskeratosis congenita (DKC) is typically characterized by the triad of abnormal cutaneous
Taimoor I. Sheikh, John B. Vincent
wiley   +1 more source

High‐throughput Profiling of Pseudouridines in Microbiome‐derived Bacterial RNA

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Pseudouridine (Ψ) is a widespread RNA modification that influences RNA stability, structure, and translation. However, its role in bacterial mRNA, particularly within complex microbiomes, remains poorly defined. Here, we describe a bisulfite‐based sequencing workflow coupled with a scalable computational pipeline for base‐resolution ...
Shikha Sharma, Ning Duan, Akintunde Emiola   +2 more
wiley   +1 more source

Converting nonsense codons into sense codons by targeted pseudouridylation [PDF]

Nature, 2011
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon. Here, we demonstrate that pseudouridylation (conversion of uridine into pseudouridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vitro and in vivo.
John, Karijolich, Yi-Tao, Yu
openaire   +2 more sources

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Mitochondrial tRNA pseudouridylation governs erythropoiesis

Blood
Abstract Pseudouridine is the most prevalent RNA modification, and its aberrant function is implicated in various human diseases. However, the specific impact of pseudouridylation on hematopoiesis remains poorly understood. Here, we investigated the role of transfer RNA (tRNA) pseudouridylation in erythropoiesis and
Bichen Wang, Deyang Shi, Shuang Yang, Yu Lian, Haoyuan Li, Mutian Cao, Yifei He, Lele Zhang, Chen Qiu, Tong Liu, Wei Wen, Yuanwu Ma, Lei Shi, Tao Cheng, Lihong Shi, Weiping Yuan, Yajing Chu, Jun Shi   +17 more
openaire   +2 more sources

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, Volume 5, Issue 3, June 2026.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, Volume 13, Issue 26, 8 May 2026.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

A homozygous synonymous NOP58 variant causes a neurodevelopmental disorder by impairing maturation of pre-ribosomal RNAs

HGG Advances
Summary: Ribosomes are ribonucleoproteins that are responsible for protein synthesis. They consist of ribosomal proteins and ribosomal RNAs (rRNAs). Pre-rRNAs are co-transcriptionally processed and chemically modified.
Loisa D. Bonde, Tess Holling, Malik Alawi, Ahmed A. El Beheiry, Zabih Mir Hassani, François Bachand, Ibrahim M. Abdelrazek, Kerstin Kutsche   +7 more
doaj   +1 more source