Results 71 to 80 of about 3,085 (163)

A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

Aging Cell, Volume 25, Issue 2, February 2026.
Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White, Kun Xiong, Matthew Wakai, Allison Surian, Christina Adler, Nicole Negron, Min Ni, Tea Shavlakadze, Yu Bai, David J. Glass   +9 more
wiley   +1 more source

Exploring pseudouridylation: dysregulation in disease and therapeutic potential

Current Opinion in Genetics & Development
Pseudouridine (Ψ), the most abundant RNA modification, plays a role in pre-mRNA splicing, RNA stability, protein translation efficiency, and cellular responses to environmental stress. Dysregulation of pseudouridylation is linked to human diseases.
Maria Guillen-Angel, Jean-Yves Roignant
openaire   +3 more sources

Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

BMC Genomics, 2019
Background Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries. Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been hypothesized to be a possible etiology ...
Ye Feng, Varune Rohan Ramnarine, Robert Bell, Stanislav Volik, Elai Davicioni, Vanessa M. Hayes, Shancheng Ren, Colin C. Collins   +7 more
doaj   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Purification of pseudouridylate synthetase I from Salmonella typhimurium

Nucleic Acids Research, 1978
Pseudouridylate synthetase from Salmonella typhimurium has been purified 1,000 fold and is about 90% pure. The enzyme has a molecular weight of 50,000 daltons. In the presence of tRNA there is a change in molecular weight from 50.000 to 100.000. This change does not seem to be due to the formation of a tRNA-enzyme complex but rather to a tRNA induced ...
F, Arena, G, Ciliberto, S, Ciampi, R, Cortese   +3 more
openaire   +3 more sources

Advancements in pseudouridine modifying enzyme and cancer

Frontiers in Cell and Developmental Biology
Pseudouridine (Ψ) is a post-transcriptional modifier of RNA, often referred to as the ‘fifth nucleotide’ owing to its regulatory role in various biological functions as well as because of its significant involvement in the pathogenesis of human cancer ...
Kaijie Liu, Shujun Zhang, Yafeng Liu, Xinjun Hu, Xinjun Hu, Xinyu Gu   +5 more
doaj   +1 more source

Contribution of protein Gar1 to the RNA-guided and RNA-independent rRNA:Ψ-synthase activities of the archaeal Cbf5 protein

Scientific Reports, 2018
Archaeal RNA:pseudouridine-synthase (PUS) Cbf5 in complex with proteins L7Ae, Nop10 and Gar1, and guide box H/ACA sRNAs forms ribonucleoprotein (RNP) catalysts that insure the conversion of uridines into pseudouridines (Ψs) in ribosomal RNAs (rRNAs ...
Ryosuke Fujikane, Isabelle Behm-Ansmant, Anne-Sophie Tillault, Christine Loegler, Valérie Igel-Bourguignon, Evelyne Marguet, Patrick Forterre, Christiane Branlant, Yuri Motorin, Bruno Charpentier   +9 more
doaj   +1 more source

2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein

Nature Communications
Telomerase is a ribonucleoprotein (RNP) enzyme that extends telomeric repeats at eukaryotic chromosome ends to counterbalance telomere loss caused by incomplete genome replication.
George E. Ghanim, Zala Sekne, Sebastian Balch, Anne-Marie M. van Roon, Thi Hoang Duong Nguyen   +4 more
doaj   +1 more source

Small Nucleolar RNAs: Insight Into Their Function in Cancer

Frontiers in Oncology, 2019
Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes: C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA box snoRNAs are 2'-O-ribose methylation and pseudouridylation of ribosomal RNAs ...
Junnan Liang, Jingyuan Wen, Zhao Huang, Xiao-ping Chen, Bi-xiang Zhang, Liang Chu   +5 more
doaj   +1 more source

Landscape of RNA pseudouridylation in archaeon Sulfolobus islandicus

Nucleic Acids Research
Abstract Pseudouridine, one of the most abundant RNA modifications, is synthesized by stand-alone or RNA-guided pseudouridine synthases. Here, we comprehensively mapped pseudouridines in rRNAs, tRNAs and small RNAs in the archaeon Sulfolobus islandicus and identified Cbf5-associated H/ACA RNAs.
Yuqian Li, Songlin Wu, Keqiong Ye
openaire   +2 more sources