Results 81 to 90 of about 3,085 (163)

Updated Pseudo-seq Protocol for Transcriptome-Wide Detection of Pseudouridines

Bio-Protocol
Pseudouridine (Ψ), the most prevalent modified base in cellular RNAs, has been mapped to numerous sites not only in rRNAs, tRNAs, and snRNAs but also mRNAs.
Yi Pan, Hironori Adachi, Xueyang He, Jonathan Chen, Yi- Yu, Paul Boutz   +5 more
doaj   +1 more source

The SMC Loader Scc2 Promotes ncRNA Biogenesis and Translational Fidelity.

PLoS Genetics, 2015
The Scc2-Scc4 complex is essential for loading the cohesin complex onto DNA. Cohesin has important roles in chromosome segregation, DSB repair, and chromosome condensation. Here we report that Scc2 is important for gene expression in budding yeast.
Musinu Zakari, Rhonda Trimble Ross, Allison Peak, Marco Blanchette, Chris Seidel, Jennifer L Gerton   +5 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

SnoRNAs: The promising targets for anti-tumor therapy

Journal of Pharmaceutical Analysis
Recently, small nucleolar RNAs (snoRNAs) have transcended the genomic “noise” to emerge as pivotal molecular markers due to their essential roles in tumor progression.
Xiaoyun Hu, Wanlin Cui, Min Liu, Fangxiao Zhang, Yingqi Zhao, Mingrong Zhang, Yuhang Yin, Yalun Li, Ying Che, Xianglong Zhu, Yuxuan Fan, Xiaolan Deng, Minjie Wei, Huizhe Wu   +13 more
doaj   +1 more source

Implications of RNA pseudouridylation for cancer biology and therapeutics: a narrative review

Journal of Translational Medicine
Background Pseudouridine (Ψ), a C5-glycoside isomer of uridine, stands as one of the most prevalent RNA modifications in all RNA types. Distinguishing from the C-N bond linking uridine to ribose, the link between Ψ and ribose is a C-C bond, endowing Ψ ...
Hanyi Ding, Na Liu, Yan Wang, Sofia Abdulkadir Adam, Jie Jin, Weiying Feng, Jie Sun   +6 more
doaj   +1 more source

PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features

Cell Genomics
Summary: PUS7 is a major mRNA pseudouridine synthase that influences gene expression and is dysregulated in neurodevelopmental disorders and cancer.
Rebecca Rodell, Ronit Jain, Hossein Shenasa, Matias Montes, Nicolas Robalin, Stefan Prodic, Eduardo Eyras, Nicole M. Martinez   +7 more
doaj   +1 more source

Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis

Cancer Cell International
Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified small RNAs during metastasis of PTC are still unclear.
Xi Wang, Hengyuan Gao, Wenjun Pu, Zhipeng Zeng, Nan Xu, Xunpeng Luo, Donge Tang, Yong Dai   +7 more
doaj   +1 more source

RNA m5C methylation in cancer: mechanisms and biological impact

Oncogenesis
RNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C)
Zhenyu Guan, Wendong Li, Yuting He, Wenzhi Guo   +3 more
doaj   +1 more source

RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond

Experimental Hematology & Oncology
The chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest with the ...
You-Peng Ding, Cui-Cui Liu, Ke-Da Yu
doaj   +1 more source

Recent developments, opportunities, and challenges in the study of mRNA pseudouridylation

RNA
Pseudouridine is an abundant mRNA modification found in diverse organisms ranging from bacteria and viruses to multicellular plants and humans. New developments in pseudouridine profiling provide quantitative tools to map mRNA pseudouridylation sites. Sparse biochemical studies establish the potential for mRNA pseudouridylation to affect most stages of
openaire   +2 more sources