Results 31 to 40 of about 883 (101)

Comprehensive analysis to identify PUS7 as a prognostic biomarker from pan-cancer analysis to osteosarcoma validation. [PDF]

Aging (Albany NY)
Pseudouridylation has demonstrated the potential to control the development of numerous malignancies. PUS7(Pseudouridine Synthase 7) is one of the pseudouridine synthases, but the literature on this enzyme is limited to several cancer types. Currently, no investigation has been performed on the systematic pan-cancer analysis concerning PUS7 role in ...
Dong B, Wang B, Fan M, Zhang J, Zhao Z.
europepmc   +3 more sources

Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We determined the genetic structure and signatures of selection in five local Indonesian sheep breeds using genome‐wide SNP data. By integrating population structure analyses with runs of homozygosity and haplotype‐based selection scans, we identified breed‐specific genomic regions associated with immunity, reproduction, pigmentation, metabolism, and ...
Putri Kusuma Astuti, Alexandru Eugeniu Mizeranschi, Herdis Herdis, Pradita Iustitia Sitaresmi, Alek Ibrahim, Sigit Prastowo, Nuzul Widyas, Tristianto Nugroho, Szilvia Kusza   +8 more
wiley   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, Volume 13, Issue 28, 18 May 2026.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Additional file 1 of HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance

, 2021
Additional file 1: Supplementary Table 1. Primer sequences used in the study. Supplementary Table 2. List of genes differentially expressed in DLD1-PUS7-KD versus DLD1-control cells using RNA-Seq. Supplementary Table 3. List of proteins differentially expressed in DLD1-PUS7-KD versus DLD1-control cells using Proteome-profiling.
Song, Dan, Guo, Ming, Xu, Shuai, Song, Xiaotian, Bai, Bin, Li, Zhengyan, Chen, Jie, An, Yanxin, Nie, Yongzhan, Wu, Kaichun, Wang, Shiqi, Zhao, Qingchuan   +11 more
openaire   +1 more source

Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

Molecular Cancer, 2018
Background Exosomes are extracellular vesicles released by almost all cell types, including cancer cells, into bodily fluids such as saliva, plasma, breast milk, semen, urine, cerebrospinal fluid, amniotic fluid, synovial fluid and sputum.
Fatima Qadir, Mohammad Arshad Aziz, Chrisdina Puspita Sari, Hong Ma, Haiyan Dai, Xun Wang, Dhiresh Raithatha, Lucas Girotto Lagreca Da Silva, Muhammad Hussain, Seyedeh P. Poorkasreiy, Iain L. Hutchison, Ahmad Waseem, Muy-Teck Teh   +12 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Next generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly

Saudi Journal of Biological Sciences, 2020
Intellectual developmental disorder with abnormal behavior, microcephaly and short stature (IDDABS), (OMIM# 618342) is an autosomal recessive condition described as developmental delay, poor or absent speech, intellectual disability, short stature, mild to progressive microcephaly, delayed psychomotor development, hyperactivity, seizure, along with ...
Naseer, Muhammad Imran, Abdulkareem, Angham Abdulrahman, Jan, Mohammed M., Chaudhary, Adeel G., Alharazy, Shatha, AlQahtani, Mohammad H.   +5 more
openaire   +2 more sources

Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank

Anaesthesia, Volume 80, Issue 5, Page 499-510, May 2025.
Summary Introduction Chronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear.
Song Li, Masja K. Toneman, Judith P. M. Mangnus, Stefano Strocchi, Regina L. M. van Boekel, Kris C. P. Vissers, Richard P. G. ten Broek, Marieke J. H. Coenen   +7 more
wiley   +1 more source

Current Advancements in Serum Protein Biomarkers for Hepatitis B Virus‐Associated Hepatocyte Remodeling and Hepatocellular Carcinoma

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
ABSTRACT Background Hepatitis B virus (HBV)‐related liver cancer is the third most common cause of cancer‐related death globally. Hepatocyte remodeling, also known as hepatocyte transformation and immortalization, and hepatocellular carcinoma (HCC), are brought on by persistent inflammation caused by HBV in the host hepatocytes.
Adane Adugna, Gashaw Azanaw Amare, Mohammed Jemal   +2 more
wiley   +1 more source