Results 11 to 20 of about 883 (101)

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients. [PDF]

Clin Genet
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Bergès C, Sauvestre C, Naudion S, Delorme CV, Smol T, Rama M, Moortgat S, Maystadt I, Kersseboom R, Wilke M, Barakat TS, Vial Y, Perrin L, Passemard S, Ahmad F, Umair M, Haack T, Grimmel M, Kuechler A, Slavotinek A, Devine P, Hodoglugil U, Zafar F, Afzal E, Dudding-Byth T, Jouret G, Herissant L, Efthymiou S, Houlden H, Legendre M, Michaud V.   +30 more
europepmc   +4 more sources

The Identification of RNA Modification Gene PUS7 as a Potential Biomarker of Ovarian Cancer [PDF]

Biology, 2021
RNA modifications are reversible, dynamically regulated, and involved in a variety of diseases such as cancers. Given the lack of efficient and reliable biomarkers for early diagnosis of ovarian cancer (OV), this study was designed to explore the role of
Huimin Li, Lin Chen, Yunsong Han, Fangfang Zhang, Yanyan Wang, Yali Han, Yange Wang, Qiang Wang, Xiangqian Guo   +8 more
doaj   +3 more sources

Pseudouridine Synthase 7 in Cancer: Functions, Mechanisms, and Therapeutic Potential [PDF]

Cells
Pseudouridylation, the most abundant RNA modification, plays a critical role in modulating RNA structure, stability, and function. Among the family of pseudouridine synthases, Pseudouridine Synthase 7 (PUS7) has recently gained attention for its emerging
Qiwei Yang, Thomas G. Boyer, Ayman Al-Hendy   +2 more
doaj   +2 more sources

Integrative analysis of nanopore direct RNA sequencing data reveals a global impact of pseudouridylation on m6A and m5C modifications [PDF]

npj Precision Oncology
RNA modifications play a crucial role in regulating cellular functions. Among the most abundant modifications in the human transcriptome are pseudouridine (Ψ), N6-methyladenosine (m6A), and 5-methylcytosine (m5C).
Mohit Bansal, Anamika Gupta, Jane Ding, Anirban Kundu, Katherine Marlow, Andrew Gibson, Zhangli Su, Sunil Sudarshan, Han-Fei Ding   +8 more
doaj   +2 more sources

Quantitative analysis of small RNA pseudouridylation reveals interplay of PUS enzymes in tRNA anticodon stem-loop [PDF]

Nature Communications
Pseudouridine (Ψ) is an abundant modification in small RNA catalyzed by multiple pseudouridine synthases (PUSs). However, the substrate specificity of human PUSs remains elusive.
Wenqing Liu, Yichen Ma, Liping Wang, Bo Lu, Yuyang Dong, Yuan Zhuang, Bo He, Meiling Zhang, Chengqi Yi   +8 more
doaj   +2 more sources

Pseudouridine synthases upregulate 5′-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma [PDF]

Cellular & Molecular Biology Letters
Transfer RNA-derived fragments (tRFs) are a recently discovered class of short noncoding RNAs widely distributed in various tissues and cell types. They are involved in the regulation of gene expression and play important roles in both physiological and ...
Daixi Ren, Mei Yang, Yongzhen Mo, Qijia Yan, Lei Shi, Shanshan Zhang, Zhaojian Gong, Can Guo, Ming Zhou, Bo Xiang, Ming Tan, Guiyuan Li, Pan Chen, Wei Xiong, Zhaoyang Zeng   +14 more
doaj   +2 more sources

PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features

Cell Genomics
Summary: PUS7 is a major mRNA pseudouridine synthase that influences gene expression and is dysregulated in neurodevelopmental disorders and cancer.
Rebecca Rodell, Ronit Jain, Hossein Shenasa, Matias Montes, Nicolas Robalin, Stefan Prodic, Eduardo Eyras, Nicole M. Martinez   +7 more
doaj   +2 more sources

Molecular Insights into Widespread Pseudouridine RNA Modifications: Implications for Women’s Health and Disease [PDF]

Biology
Pseudouridine (Ψ), the most abundant RNA modification, plays essential roles in shaping RNA structure, stability, and translational output. Beyond cancer, Ψ is dynamically regulated across numerous physiological and pathological contexts—including immune
Qiwei Yang, Ayman Al-Hendy, Thomas G. Boyer   +2 more
doaj   +2 more sources

Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis [PDF]

Cancer Cell International
Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified small RNAs during metastasis of PTC are still unclear.
Xi Wang, Hengyuan Gao, Wenjun Pu, Zhipeng Zeng, Nan Xu, Xunpeng Luo, Donge Tang, Yong Dai   +7 more
doaj   +2 more sources

Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer [PDF]

International Journal of General Medicine
Shaoyu Wang,1– 3 Qiaomei Zheng,1– 3 Lihong Chen1– 3 1Department of Obstetrics and Gynecology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China; 2Department of Obstetrics and Gynecology, National ...
Wang S, Zheng Q, Chen L
doaj   +2 more sources