Interplay of RNA m<sup>6</sup>A/m<sup>1</sup>A/m<sup>5</sup>C/m<sup>7</sup>G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer. [PDF]
FASEB BioadvIn this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Chen S, Mao J, Xu L, Lu L, Hao Y.
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Journal of Cardiothoracic Surgery, 2023 Background Lung cancer is currently the second most common cancer, and non-small cell lung cancer accounts for about 85% of cases. NSCLC has not been studied for pseudouridine synthase 7 (PUS), a member of the PUS family that is associated with cancer ...
Guihong Zhang +6 more
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A novel PUS7 mutation causes intellectual disability with autistic and aggressive behaviors [PDF]
Neurology Genetics, 2019 Recently, homozygous PUS7 mutations causing premature stop and truncation of the gene product were identified in 3 independent consanguineous families presenting with intellectual disability (ID), speech delay, short stature, microcephaly, and aggressive behavior.1 PUS7 encodes for a pseudouridine synthase 7 that catalyzes the isomerization of RNA ...
Darvish, Hossein +7 more
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Frontiers in Genetics, 2022 Background: The pseudouridine synthases (PUSs) have been reported to be associated with cancers. However, their involvement in hepatocellular carcinoma (HCC) has not been well documented.
Zhipeng Jin +6 more
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Integrative Genomic Analysis Reveals Pseudouridine Modification-Related Gene Signatures Associated With Prognosis and Therapeutic Response Patterns in Hepatocellular Carcinoma. [PDF]
Int J GenomicsBackground Hepatocellular carcinoma (HCC) is a genomically heterogeneous malignancy with substantial variability in prognosis and therapeutic response. Pseudouridine (Ψ) modification is an evolutionarily conserved RNA modification involved in RNA structure stabilization and translational regulation; however, the genomic and functional relevance of ...
Gan Z, Fan T, Wang W, Qiao X, Zhao M.
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RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]
MedComm (2020)Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Li Q, Sun Y, Lin S, Yuan Q.
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Cells, 2023 Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is the truncal driver mutation of most cases of ccRCC.
Daniel A. Mohl +10 more
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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives. [PDF]
Clin Transl MedThis review discusses the regulatory mechanisms and pathological significance of pseudouridylation in human diseases, with a special emphasis on its involvement in tumourigenesis. Furthermore, the potential therapeutic advantages of targeting pseudouridylation are explored, offering novel strategies for disease treatment. Abstract RNA pseudouridylation,
Jia S +10 more
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PUS7 Deficiency: Phenotypical Expansion of PUS7 ‐Related Neurodevelopmental Disorders
American Journal of Medical Genetics Part AABSTRACT Pathogenic variants in PUS7 , encoding pseudouridine synthase 7, cause a rare neurodevelopmental disorder marked by intellectual disability, microcephaly, short stature, and behavioral disturbances.
Alice Muda +5 more
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