Results 11 to 20 of about 431,100 (179)

The molecular basis of tRNA selectivity by human pseudouridine synthase 3 [PDF]

Molecular Cell
Pseudouridine (Ψ), the isomer of uridine, is ubiquitously found in RNA, including tRNA, rRNA, and mRNA. Human pseudouridine synthase 3 (PUS3) catalyzes pseudouridylation of position 38/39 in tRNAs. However, the molecular mechanisms by which it recognizes its RNA targets and achieves site specificity remain elusive.
Sebastian Glatt, Grzegorz Wazny
exaly   +7 more sources

Steroid receptor RNA activator (SRA) modification by the human pseudouridine synthase 1 (hPus1p): RNA binding, activity, and atomic model. [PDF]

PLoS ONE, 2014
The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases.
Tiphaine Huet, François-Alexandre Miannay, Jeffrey R Patton, Stéphane Thore   +3 more
doaj   +3 more sources

Evolution of Eukaryal and Archaeal Pseudouridine Synthase Pus10. [PDF]

J Mol Evol, 2018
In archaea, pseudouridine (Ψ) synthase Pus10 modifies uridine (U) to Ψ at positions 54 and 55 of tRNA. In contrast, Pus10 is not found in bacteria, where modifications at those two positions are carried out by TrmA (U54 to m5U54) and TruB (U55 to Ψ55).
Fitzek E, Joardar A, Gupta R, Geisler M.
europepmc   +7 more sources

Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2022
Pseudouridine (Ψ) is a ubiquitous RNA modification incorporated by pseudouridine synthase (Pus) enzymes into hundreds of noncoding and protein-coding RNA substrates.
Monika K Franco, Daniel E Eyler, Kristin S Koutmou   +2 more
exaly   +3 more sources

Aging-induced pseudouridine synthase 10 impairs hematopoietic stem cells [PDF]

Haematologica, 2023
Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood.
Yuqian Wang, Zhenzhen Zhang, Hanqing He, Jinghui Song, Yang Cui, Yunan Chen, Yuan Zhuang, Xiaoting Zhang, Mo Li, Xinxiang Zhang, Michael Q. Zhang, Minglei Shi, Chengqi Yi, Jianwei Wang   +13 more
doaj   +2 more sources

Linking pseudouridine synthases to growth, development and cell competition [PDF]

The FEBS Journal, 2010
Eukaryotic pseudouridine synthases direct RNA pseudouridylation and bind H/ACA small nucleolar RNA (snoRNAs), which, in turn, may act as precursors of microRNA‐like molecules. In humans, loss of pseudouridine synthase activity causes dyskeratosis congenita (DC), a complex systemic disorder characterized by cancer susceptibility, failures in ribosome ...
TORTORIELLO, GIUSEPPE, J. F. de Celis, FURIA, MARIA   +2 more
openaire   +4 more sources

Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

Cell Reports
Summary: Pseudouridine is the most abundant epitranscriptomic modification, but its cellular functions remain poorly understood. Here, we identify pseudouridine synthase 1 (PUS1) as a key driver of tumor immune evasion. Specifically, we find that PUS1 is
Fan Wang, Yu Tong, Wenyun Guo, Yifei Qian, Zijun Zhu, Songling Li, Linfeng Li, Qianyu Li, Wei-Qiang Gao, Yanfeng Liu   +9 more
doaj   +2 more sources

Transcriptome-wide mapping of pseudouridines: pseudouridine synthases modify specific mRNAs in S. cerevisiae. [PDF]

PLoS ONE, 2014
We developed a novel technique, called pseudouridine site identification sequencing (PSI-seq), for the transcriptome-wide mapping of pseudouridylation sites with single-base resolution from cellular RNAs based on the induced termination of reverse ...
Alexander F Lovejoy, Daniel P Riordan, Patrick O Brown   +2 more
doaj   +4 more sources

Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation [PDF]

iScience
Summary: Pseudouridylation plays a regulatory role in various physiological and pathological processes. A prime example is the mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome (MLASA), characterized by defective ...
Deyang Shi, Bichen Wang, Haoyuan Li, Yu Lian, Qiuyi Ma, Tong Liu, Mutian Cao, Yuanwu Ma, Lei Shi, Weiping Yuan, Jun Shi, Yajing Chu   +11 more
doaj   +2 more sources

The pseudouridine synthase PUS7 is associated with stemness and represents a potential therapeutic target in triple-negative breast cancer cells [PDF]

Scientific Reports
Triple-negative breast cancer (TNBC) represents a highly aggressive subtype of breast cancer characterized by increased recurrence rates and poor prognosis, primarily due to the lack of effective therapeutic targets.
Lu Lu, Lian Xue, Shiyao Jiang, Guangchun He, Xiyun Deng   +4 more
doaj   +2 more sources