Results 71 to 80 of about 1,720,439 (181)
EnsemPseU: Identifying Pseudouridine Sites With an Ensemble Approach
IEEE Access, 2020 Pseudouridine (Ψ) is the most prevalent RNA modification, which is formed from uridine through an isomerization reaction. With the increasing availability of genomic and proteomic samples, computer-aided pseudouridine-synthase-specific Ψ ...
Yue Bi, Dong Jin, Cangzhi Jia
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Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 1973-2000, July 2026.Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu +7 more
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A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach
Molecules, 2018 An in silico study has been conducted upon (3′RS,5′SR)-5-[2′-benzyl-5′-hydroxymethyl-1′,2′-isoxazolidin-3′-yl]uracil through a molecular dynamics/docking approach that highlights its potential inhibitory activity upon the wild-type pseudouridine 5 ...
Giuseppe Floresta +7 more
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ChemBioChem, Volume 27, Issue 11, 15 June 2026.Ribonucleotide reductases (RNRs) are valuable biocatalysts for the biosynthesis of non‐natural deoxyribonucleotide, relevant in fields like medical science and synthetic biology. In this study, we explore the substrate spectrum of two thermostable RNRs and discuss their implications for nucleotide metabolism and biocatalytical applications ...
Lobna Eltoukhy, Christoph Loderer
wiley +1 more source
iRNA-PseU: Identifying RNA pseudouridine sites
Molecular Therapy: Nucleic Acids, 2016 As the most abundant RNA modification, pseudouridine plays important roles in many biological processes. Occurring at the uridine site and catalyzed by pseudouridine synthase, the modification has been observed in nearly all kinds of RNA, including ...
Wei Chen +4 more
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VaccinesTherapeutic modified mRNAs are being developed for a broad range of human diseases. However, the impact of potential miscoding of modified mRNAs on self-tolerance remains unknown. Additionally, more studies are needed to explore the effects of nucleoside
Mouldy Sioud +2 more
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Biosynthesis of Pseudouridine in Transfer Ribonucleic Acid
Journal of Biological Chemistry, 1974 An enzyme that catalyzes the formation of specific pseudouridine residues in the anticodon region of tRNA has been characterized in extracts of Salmonella typhimurium and Escherichia coli. It has previously been shown that hisT regulatory mutants of S.
CORTESE, RICCARDO +3 more
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iPseU-NCP: Identifying RNA pseudouridine sites using random forest and NCP-encoded features
BMC Genomics, 2019 Background Pseudouridine modification is most commonly found among various kinds of RNA modification occurred in both prokaryotes and eukaryotes. This biochemical event has been proved to occur in multiple types of RNAs, including rRNA, mRNA, tRNA, and ...
Thanh-Hoang Nguyen-Vo +5 more
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PLoS ONE, 2014 The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases.
Tiphaine Huet +3 more
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RNA BiologyPseudouridine is a noncanonical C-nucleoside containing a C-C glycosidic linkage between uracil and ribose. In the two-step degradation of pseudouridine, pseudouridine 5’-monophosphate glycosylase (PUMY) is responsible for the second step and catalyses ...
Jeongyun Lee +2 more
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