Results 71 to 80 of about 1,745,918 (176)
EnsemPseU: Identifying Pseudouridine Sites With an Ensemble Approach
IEEE Access, 2020 Pseudouridine (Ψ) is the most prevalent RNA modification, which is formed from uridine through an isomerization reaction. With the increasing availability of genomic and proteomic samples, computer-aided pseudouridine-synthase-specific Ψ ...
Yue Bi, Dong Jin, Cangzhi Jia
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A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess +1 more
wiley +1 more source
iRNA-PseU: Identifying RNA pseudouridine sites
Molecular Therapy: Nucleic Acids, 2016 As the most abundant RNA modification, pseudouridine plays important roles in many biological processes. Occurring at the uridine site and catalyzed by pseudouridine synthase, the modification has been observed in nearly all kinds of RNA, including ...
Wei Chen +4 more
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VaccinesTherapeutic modified mRNAs are being developed for a broad range of human diseases. However, the impact of potential miscoding of modified mRNAs on self-tolerance remains unknown. Additionally, more studies are needed to explore the effects of nucleoside
Mouldy Sioud +2 more
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Biosynthesis of Pseudouridine in Transfer Ribonucleic Acid
Journal of Biological Chemistry, 1974 An enzyme that catalyzes the formation of specific pseudouridine residues in the anticodon region of tRNA has been characterized in extracts of Salmonella typhimurium and Escherichia coli. It has previously been shown that hisT regulatory mutants of S.
CORTESE, RICCARDO +3 more
openaire +3 more sources
iPseU-NCP: Identifying RNA pseudouridine sites using random forest and NCP-encoded features
BMC Genomics, 2019 Background Pseudouridine modification is most commonly found among various kinds of RNA modification occurred in both prokaryotes and eukaryotes. This biochemical event has been proved to occur in multiple types of RNAs, including rRNA, mRNA, tRNA, and ...
Thanh-Hoang Nguyen-Vo +5 more
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PLoS ONE, 2014 The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases.
Tiphaine Huet +3 more
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RNA BiologyPseudouridine is a noncanonical C-nucleoside containing a C-C glycosidic linkage between uracil and ribose. In the two-step degradation of pseudouridine, pseudouridine 5’-monophosphate glycosylase (PUMY) is responsible for the second step and catalyses ...
Jeongyun Lee +2 more
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OsPPG encodes a pseudouridine-5′-phosphate glycosidase and regulates rice spikelet development
Crop JournalFlorets are the basic structural units of spikelets, and their morphogenesis determines the yield and quality of rice grains. However, whether and how pseudouridine-5′-phosphate glycosidase participates in rice spikelet development remains an open ...
Rui Chen +11 more
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Implications of RNA pseudouridylation for cancer biology and therapeutics: a narrative review
Journal of Translational MedicineBackground Pseudouridine (Ψ), a C5-glycoside isomer of uridine, stands as one of the most prevalent RNA modifications in all RNA types. Distinguishing from the C-N bond linking uridine to ribose, the link between Ψ and ribose is a C-C bond, endowing Ψ ...
Hanyi Ding +6 more
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