Results 91 to 100 of about 1,806,143 (218)
VaccinesTherapeutic modified mRNAs are being developed for a broad range of human diseases. However, the impact of potential miscoding of modified mRNAs on self-tolerance remains unknown. Additionally, more studies are needed to explore the effects of nucleoside
Mouldy Sioud +2 more
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Detection of pseudouridine synthase activity with a fluorescence-based yeast reporter system [PDF]
, 2020 Pseudouridine is an isomer of uridine and a post-transcriptional RNA modification in all domains of life. Its formation is catalyzed by pseudouridine synthases functioning as standalone proteins or protein-RNA complexes called H/ACA small nucleolar ...
University of Lethbridge. Faculty of Arts and Science +1 more
core
Data Analysis Pipeline for Detection and Quantification of Pseudouridine (ψ) in RNA by HydraPsiSeq
, 2023 International audiencePseudouridine, a modified RNA residue formed by the isomerization of its parental U nucleotide, is prevalent in a majority of cellular RNAs; its presence was reported in tRNA, rRNA, and sn/snoRNA as well as in mRNA/lncRNA.
Helm, Mark +3 more
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Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold
, 2004 TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have
Kaya, Yusuf +3 more
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, 2018 mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity.
Kauffman, Kevin John +10 more
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, 1993 The serum level of pseudouridine, a modified nucleoside deriving mainly from t-RNA catabolism, was evaluated in 66 acute leukaemia patients at diagnosis to investigate its diagnostic and prognostic value, and its potential as a parameter with which to ...
FORTUNATO, GIULIANA +13 more
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Quantification of Pseudouridine Modifications through UridineSpecific Cleavage of RNA
, 2016 Pseudouridine (Ψ), an isomer of uridine (U), is the most common post-transcriptional modification found in RNA (1). Detection and quantification of pseudouridine (Y) in RNA is challenging.
Aninweze, Adaeze
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BiologyPseudouridine (Ψ), the most abundant RNA modification, plays essential roles in shaping RNA structure, stability, and translational output. Beyond cancer, Ψ is dynamically regulated across numerous physiological and pathological contexts—including immune
Qiwei Yang +2 more
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Biosynthesis of Pseudouridine in Transfer Ribonucleic Acid
Journal of Biological Chemistry, 1974 An enzyme that catalyzes the formation of specific pseudouridine residues in the anticodon region of tRNA has been characterized in extracts of Salmonella typhimurium and Escherichia coli. It has previously been shown that hisT regulatory mutants of S.
CORTESE, RICCARDO +3 more
openaire +3 more sources
Fuzzy kernel evidence Random Forest for identifying pseudouridine sites
Pseudouridine is an RNA modification that is widely distributed in both prokaryotes and eukaryotes, and plays a critical role in numerous biological activities.
Ding, Yijie, +4 more
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