Results 111 to 120 of about 1,806,143 (218)

Transport kinetics of pseudouridine during hemodialysis and continuous ambulatory peritoneal dialysis

, 1991
It has been found that the concentrations of pseudouridine in serum of patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are higher than those in patients undergoing hemodialysis.
Koomen, G. C., Schoots, A. C., Krediet, R. T., Koole, L. H., Arisz, L., van der Reijden, H. J., Struijk, D. G.   +6 more
core  

Implications of RNA pseudouridylation for cancer biology and therapeutics: a narrative review

Journal of Translational Medicine
Background Pseudouridine (Ψ), a C5-glycoside isomer of uridine, stands as one of the most prevalent RNA modifications in all RNA types. Distinguishing from the C-N bond linking uridine to ribose, the link between Ψ and ribose is a C-C bond, endowing Ψ ...
Hanyi Ding, Na Liu, Yan Wang, Sofia Abdulkadir Adam, Jie Jin, Weiying Feng, Jie Sun   +6 more
doaj   +1 more source

The molecular basis of tRNA selectivity by human pseudouridine synthase 3 [PDF]

Pseudouridine (Ψ), the isomer of uridine, is ubiquitously found in RNA, including tRNA, rRNA, and mRNA. Human pseudouridine synthase 3 (PUS3) catalyzes pseudouridylation of position 38/39 in tRNAs. However, the molecular mechanisms by which it recognizes
Lin, Ting-Yu, Indyka, Paulina, Dobosz, Dominika, A. Leidel, Sebastian, Rawski, Michał, Ranff, Tristan, Chramiec-Głąbik, Andrzej, Bereta, Joanna, Leidel, Sebastian A, Fufezan, Christian, Koziej, Łukasz, Kleemann, Leon, Mehta, Rahul, Koziej, Lukasz, Chramiec-Glabik, Andrzej, Wawro, Mateusz, Rawski, Michal, Jezowski, Jakub, Glatt, Sebastian, Leidel, Sebastian A., Wazny, Grzegorz, Kochan, Jakub   +21 more
core   +2 more sources

Pseudouridine Residues as Substrates for Serum Ribonucleases

RNA
In clinical uses, RNA must maintain its integrity in serum that contains ribonucleases (RNases), especially RNase 1, which is a human homolog of RNase A. These omnipresent enzymes catalyze the cleavage of the P–O5′′ bond on the 3′ side of pyrimidine residues. Pseudouridine (Ψ) is the most abundant modified nucleoside in natural RNA. The substitution of
Clair S. Gutierrez, Bjarne Silkenath, Volga Kojasoy, Jaroslaw A. Pich, Daniel C. Lim, Ronald T. Raines   +5 more
openaire   +2 more sources

Survival of the Fittest: Elucidating Fitness of Escherichia coli strains Lacking Pseudouridine Synthases

, 2018
The ribosome is a fundamental component of gene expression, producing proteins from corresponding mRNA sequences. The ribosome is comprised largely of ribosomal RNA (rRNA), which is known to contain various nucleotide modifications.
Kothe, Ute, Soon, Emily, Vienneau*, Hope
core  

Mapping pseudouridine modifications in MicroRNA: a quantitative analytical approach

Pseudouridine is one of the most abundant post-transcriptional modifications in cellular RNA, but has not been extensively characterized in microRNA, a dominant group of small (
Liu, Tiffany Zhi Yu
core  

Integrative analysis of nanopore direct RNA sequencing data reveals a global impact of pseudouridylation on m6A and m5C modifications

npj Precision Oncology
RNA modifications play a crucial role in regulating cellular functions. Among the most abundant modifications in the human transcriptome are pseudouridine (Ψ), N6-methyladenosine (m6A), and 5-methylcytosine (m5C).
Mohit Bansal, Anamika Gupta, Jane Ding, Anirban Kundu, Katherine Marlow, Andrew Gibson, Zhangli Su, Sunil Sudarshan, Han-Fei Ding   +8 more
doaj   +1 more source

Combining in silico and in vitro studies on tRNA dynamics and pseudouridine formation by TruB [PDF]

, 2013
ix, 134 leaves : ill. (some col.) ; 29 cmRNA is an important molecule in the cell capable of carrying sequence information for protein production and acting as a functional component in essential cellular processes.
Friedt, Jenna
core  

Ascitic pseudouridine discriminates between hepatocarcinoma-derived ascites and cirrhotic ascites

, 1996
Various biochemical indexes discriminate neoplastic from nonneoplastic ascites. However, within the latter group, the distinction between cirrhotic ascites and ascites caused by hepatocarcinoma (HC) is usually based on liver biopsy or cytology.
CASTALDO G, SACCHETTI L, G. CALCAGNO, CALCAGNO G, L. CIMINO, CIMINO L, L. SACCHETTI, G. BUDILLON, SALVATORE F., CASTALDO, GIUSEPPE, INTRIERI M, CIMINO, LUCIA, M. INTRIERI, SALVATORE, FRANCESCO, G. CASTALDO, BUDILLON G   +15 more
core  

Loss of Pseudouridine Synthases in the RluA Family Causes Hypersensitive Nociception in Drosophila

G3: Genes, Genomes, Genetics, 2020
Wan Song, Susanne Ressl, W. Daniel Tracey   +2 more
doaj   +1 more source