Results 131 to 140 of about 1,720,439 (181)

RNA pseudouridine modification in plants

Journal of Experimental Botany, 2023
Abstract Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models ...
Lingyun Liu, Pablo A Manavella, Niu Yanli   +2 more
exaly   +3 more sources

Semi-enzymatic synthesis of pseudouridine

Bioorganic and Medicinal Chemistry Letters, 2021
Modifications of RNA molecules have a significant effect on their structure and function. One of the most common modifications is the isomerization from uridine to pseudouridine. Despite its prevalence in natural RNA sequences, organic synthesis of pseudouridine has been challenging because of the stereochemistry requirement and the sensitivity of ...
Andrew T Riley, Elliot P Clerc, Minako Sumita   +2 more
exaly   +3 more sources

Pseudouridine Modifications in Transfer RNA and tRNA Pseudouridine Synthases

Journal of Molecular Biology
Among the various modifications found in transfer RNAs, pseudouridine occurs the most frequently in all organisms and is also found in other RNA species including ribosomal, messenger, small nuclear, small nucleolar, and transfer-messenger RNA. Since the first gene encoding a tRNA pseudouridine synthase (truA) was discovered in 1978, many pseudouridine
Chie Tomikawa
exaly   +3 more sources

A synthesis of pseudouridine

Journal of the Chemical Society, Perkin Transactions 1, 1981
2,3,5-Tri-O-benzylribose and 2,4-di-t-butoxy-5-lithiopyrimidine (from the 5-bromo-compound and butyllithium) in THF at –78 °C give 5-(2,3,5-tri-O-benzyl-D-altro-pentahydroxypentyl)-2,4-di-t-butoxypyrimidine and its D-allo-epimer (ratio 5:2), which cyclise stereospecifically in ethanolic hydrochloric acid to 5-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl ...
Daniel M. Brown, Richard C. Ogden
openaire   +1 more source

The Biochemistry of Pseudouridine

1966
Publisher Summary The chapter discusses the biochemistry of pseudouridine. It also discusses in a critical, selective, and occasionally speculative fashion, the special enzymological properties, the mode of biosynthesis, and the biological role of pseudouridine.
E, Goldwasser, R L, Heinrikson
openaire   +2 more sources

Preparation of 14C-pseudouridine

Analytical Biochemistry, 1968
Abstract A method is deseribed by which 14 C-pseudouridine may be isolated from the culture medium of A. tumefaciens grown on a synthetic medium containing glucose and 2- 14 C-uracil. The method is simple and relatively rapid, and yields the natural form of pseudouridine with a specific activity equivalent to that of the uracil used.
M, Jacobson, C, Hedgcoth
openaire   +2 more sources

Pseudouridine: Biosynthesis by Streptoverticillicum ladakanus

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Recent studies have shown that pseudouridine in tRNA is formed by rearrangement of UMP residues. In the studies reported, information was not provided to clarify if the rearrangement of UMP residues to pseudouridine 5′-monophosphate was intramolecular or intermolecular.
T, Uematsu, R J, Suhadolnik
openaire   +2 more sources

Mapping Pseudouridines in RNA Molecules

Methods, 2001
Pseudouridine is present in ribosomal RNA, transfer RNA, tmRNA, and small nuclear and nucleolar RNAs. All are structured molecules. Pseudouridine is made by enzyme-catalyzed isomerization of specifically selected U residues after the polynucleotide chain is made. No energy input is required.
J, Ofengand, M, Del Campo, Y, Kaya
openaire   +2 more sources