Results 11 to 20 of about 1,806,143 (218)
Chemistry & Biology, 2006 Pseudouridine synthases are the enzymes responsible for the most abundant posttranscriptional modification of cellular RNAs. These enzymes catalyze the site-specific isomerization of uridine residues that are already part of an RNA chain, and appear to employ both sequence and structural information to achieve site specificity.
Hamma, Tomoko +1 more
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Multiomics and machine learning-based analysis of pancancer pseudouridine modifications
Discover OncologyPseudouridine widely affects the stability and function of RNA. However, our knowledge of pseudouridine properties in tumors is incomplete. We systematically analyzed pseudouridine synthases (PUSs) expression, genomic aberrations, and prognostic features
Jiheng Zhang +8 more
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iRNA-PseU: Identifying RNA pseudouridine sites
Molecular Therapy: Nucleic Acids, 2016 As the most abundant RNA modification, pseudouridine plays important roles in many biological processes. Occurring at the uridine site and catalyzed by pseudouridine synthase, the modification has been observed in nearly all kinds of RNA, including ...
Wei Chen +4 more
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Identification of RNA pseudouridine sites using deep learning approaches.
PLoS ONE, 2021 Pseudouridine(Ψ) is widely popular among various RNA modifications which have been confirmed to occur in rRNA, mRNA, tRNA, and nuclear/nucleolar RNA. Hence, identifying them has vital significance in academic research, drug development and gene therapies.
Abu Zahid Bin Aziz +2 more
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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy
Cell ReportsSummary: Pseudouridine is the most abundant epitranscriptomic modification, but its cellular functions remain poorly understood. Here, we identify pseudouridine synthase 1 (PUS1) as a key driver of tumor immune evasion. Specifically, we find that PUS1 is
Fan Wang +9 more
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Pseudouridine Chemical Labeling and Profiling
, 2015 Pseudouridine (Ψ) is the most abundant posttranscriptional RNA modification; yet little is known about its prevalence and function in messenger RNA, mostly due to the challenges in the transcriptome-wide detection of Ψ. Here, we report CeU-Seq-a selective chemical labeling and pull-down method for the comprehensive analysis of transcriptome-wide ...
Xiaoyu, Li, Shiqing, Ma, Chengqi, Yi
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Agricultural and Food Science, 1998 The potential of the spot urine sampling technique to assess urinary pseudouridine excretion was evaluated. Twelve multiparous Holstein-Friesian cows were fed two experimental diets in a complete change-over design with two 14 day experimental periods ...
Kevin J. Shingfield, Nicholas W. Offer
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Data-informed reparameterization of modified RNA and the effect of explicit water models: Application to pseudouridine and derivatives [PDF]
, 2022 Pseudouridine is the most abundant post-transcriptional modification in RNA. We have previously shown that the FF99-derived parameters for pseudouridine and some of its naturally occurring derivatives in the AMBER distribution either alone or in ...
Ansuman, Lahiri +3 more
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, 2023 Pseudouridimycin is a microbial C-nucleoside natural product that specifically inhibits bacterial RNA polymerases by binding to the active site and competing with uridine triphosphate for the nucleoside triphosphate (NTP) addition site.
Robert Schnell (332808) +8 more
core +1 more source
Pseudouridines in spliceosomal snRNAs [PDF]
Protein & Cell, 2011 Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
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