Results 11 to 20 of about 1,720,439 (181)
Pseudouridines and Pseudouridine Synthases of the Ribosome
Cold Spring Harbor Symposia on Quantitative Biology, 2001 psi are ubiquitous in ribosomal RNA. Eubacteria, Archaea, and eukaryotes all contain psi, although their number varies widely, with eukaryotes having the most. The small ribosomal subunit can apparently do without psi in some organisms, even though others have as many as 40 or more.
J, Ofengand +7 more
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RNA Biology, 2022 Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein +5 more
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Molecular Therapy: Nucleic Acids, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive single-stranded RNA virus, engages in complex interactions with host cell proteins throughout its life cycle. While these interactions enable the host to recognize and inhibit viral
Roberto Giambruno +16 more
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Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
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Ribosomal RNA pseudouridines and pseudouridine synthases [PDF]
FEBS Letters, 2002 Pseudouridines are found in virtually all ribosomal RNAs but their function is unknown. There are four to eight times more pseudouridines in eukaryotes than in eubacteria. Mapping 19 Haloarcula marismortui pseudouridines on the three‐dimensional 50S subunit does not show clustering.
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Chemistry & Biology, 2006 Pseudouridine synthases are the enzymes responsible for the most abundant posttranscriptional modification of cellular RNAs. These enzymes catalyze the site-specific isomerization of uridine residues that are already part of an RNA chain, and appear to employ both sequence and structural information to achieve site specificity.
Hamma, Tomoko +1 more
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The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
Frontiers in Cell and Developmental Biology, 2021 The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide.
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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tRNA Modifications: Impact on Structure and Thermal Adaptation
Biomolecules, 2017 Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules between the informational level of nucleic acids and the functional level of proteins.
Christian Lorenz +2 more
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The regulation of antiviral innate immunity through non-m6A RNA modifications
Frontiers in Immunology, 2023 The post-transcriptional RNA modifications impact the dynamic regulation of gene expression in diverse biological and physiological processes. Host RNA modifications play an indispensable role in regulating innate immune responses against virus infection
Shenghai Shen +2 more
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Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine
Molecules, 2020 We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year.
William H. Gmeiner
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