Results 91 to 100 of about 237 (128)

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia.

Biomolecules & biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) to identify m1A peaks and the expression profile of mRNA in the decidua of humans with early ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
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RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
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Effect of N1-methyladenosine in the quantification of RNA

The Journal of Biochemistry
Abstract The reverse transcription (RT) of RNA to cDNA is a key step for the quantification of nucleic acid molecules in numerous basic research and medical diagnosis. Although multiple sources of errors have been considered, little is known about the impact of RNA modifications on the validity of genes of interest for quantitative RT ...
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Faculty Opinions recommendation of Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
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Targeting N1-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis

Signal Transduction and Targeted Therapy
Haijian Sun, Wei Wang, Chi Zhang, Tehan Zhang, Xiaoli Yang, Yanbin Feng, Liying Shan, Zheng Yang, Yan Zhang, Shenghou Liu, Wenzhao Wang, Juncheng Wang, Xuben Hou, Shiqing Feng   +13 more
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The N1‐methyladenosine methyltransferase TRMT61A promotes bladder cancer progression and is targetable by small molecule compounds

Clinical and Translational Medicine
Jianjian Yin, Xin Fan, Qi Chang, Yuanheng Dai, Tao Wang, Lei Shi, Linlin Yang, Xiaoming Yang, Xudong Zhang, Lei Jin, Tao Liu, Fengmin Shao, Lirong Zhang, Dongkui Song   +13 more
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Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival

DNA and Cell Biology, 2021
N1-methyladenosine (m1A) is a prevalent RNA modification widely affecting RNA structural stability, folding, and interactions with proteins. Recently, there have been increasing reports on the roles of m1A regulators in tumors. However, their mechanisms and clinical relevance remain unclear.
Juan, Li, Chunting, Zhang, Xin, Yuan, Yuan, Cao   +3 more
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N1-methyladenosine methylome in messenger RNA and non-coding RNA

Current Opinion in Chemical Biology, 2018
Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N1-methyladenosine (m1A), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA.
Xushen, Xiong, Xiaoyu, Li, Chengqi, Yi
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Abstract 1713: TRMT6-mediated N1-methyladenosine methylation promotes tumorigenesis in colorectal cancer

Cancer Research, 2023
Abstract Background: N1-methyladenosine (m1A) within tRNAs, an essential and highly conserved RNA modification, has recently emerged as a significant epigenetic modification that plays a pivotal role in tumor progression in some cancers. However, the role of m1A methylation in colorectal cancer (CRC) remains largely unexplored.
SILEI SUI, CAIMING XU, Ying Qing, Hideo Baba, Ajay Goel   +4 more
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The Secret Life of N1-methyladenosine: A Review on its Regulatory Functions

Journal of Molecular Biology
N1-methyladenosine (m1A) is a conserved modification on house-keeping RNAs, including tRNAs and rRNAs. With recent advancement on m1A detection and mapping, m1A is revealed to have a secret life with regulatory functions. This includes the regulation of its canonical substrate tRNAs, and expands into new territories such as tRNA fragments, mRNAs and ...
Nhi Yen Tran, Nguyen, Xisheng, Liu, Anindya, Dutta, Zhangli, Su   +3 more
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