Results 91 to 100 of about 3,755 (152)

Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity

Ecotoxicology and Environmental Safety
The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health.
Rongxian Li, Yuan Zhao, Jiao Dai, Nan Zhang, Jiamin Yuan, De Liu, Zuoshun He, Jie Yang, Shiyan Gu   +8 more
doaj   +1 more source

Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy

Pharmacological Research
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis.
Li Liu, Linxing Yu, Yubo Wang, Liufang Zhou, Yan Liu, Xingshou Pan, Jianjun Huang   +6 more
doaj   +1 more source

N¹-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction. [PDF]

Cell Death Discov, 2023
Qi Z, Zhang C, Jian H, Hou M, Lou Y, Kang Y, Wang W, Lv Y, Shang S, Wang C, Li X, Feng S, Zhou H.   +12 more
europepmc   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +1 more source

N¹-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. [PDF]

Nat Commun, 2021
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z.   +12 more
europepmc   +1 more source

Effect of N1-methyladenosine in the quantification of RNA

The Journal of Biochemistry
Abstract The reverse transcription (RT) of RNA to cDNA is a key step for the quantification of nucleic acid molecules in numerous basic research and medical diagnosis. Although multiple sources of errors have been considered, little is known about the impact of RNA modifications on the validity of genes of interest for quantitative RT ...
openaire   +2 more sources

Alkbh3 functions with Nupr1 in a n1-methyladenosine dependent manner.

We measured total in conjunction with N1-methyladenosine marks in human cells lacking Alkbh3 to understand function of the m1A mark in transcriptional biology and the immune system. We demonstrate here interaction of Alkbh3 with Nupr1.     
openaire   +1 more source

Targeting N¹-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis. [PDF]

Signal Transduct Target Ther
Sun H, Wang W, Zhang C, Zhang T, Yang X, Feng Y, Shan L, Yang Z, Zhang Y, Liu S, Wang W, Wang J, Hou X, Feng S.   +13 more
europepmc   +1 more source

A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N¹-Methyladenosine in Urine Samples. [PDF]

Chemistry
Bağda E, Bağda E, Liu J.
europepmc   +1 more source