Results 31 to 40 of about 1,458 (131)
Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions [PDF]
ACS Chemical Biology, 2016 Environmental and endogenous genotoxic agents can result in a variety of alkylated and carboxymethylated DNA lesions, including N3-ethylthymidine (N3-EtdT), O(2)-EtdT, and O(4)-EtdT as well as N3-carboxymethylthymidine (N3-CMdT) and O(4)-CMdT. By using nonreplicative double-stranded vectors harboring a site-specifically incorporated DNA lesion, we ...
You, Changjun +6 more
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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells [PDF]
Genome Medicine, 2015 Abstract Background The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood.
Liefke, Robert +6 more
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Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
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Journal of Translational Medicine, 2021 Background Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether cells distinguish aberrant from ...
Kristian Lied Wollen +13 more
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Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase [PDF]
Nucleic Acids Research, 2019 Abstract The integrity of our DNA is challenged daily by a variety of chemicals that cause DNA base alkylation. DNA alkylation repair is an essential cellular defence mechanism to prevent the cytotoxicity or mutagenesis from DNA alkylating chemicals.
Monisha Mohan +4 more
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The ASCC2 CUE domain in the ALKBH3–ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin [PDF]
Journal of Biological Chemistry, 2022 Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked polyubiquitin chains are assembled that localize the Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3-Activating Signal Cointegrator 1 Complex Subunit (ASCC) repair complex to damage sites in the
Patrick M. Lombardi +19 more
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Function and clinical significance of N6-methyladenosine in digestive system tumours
Experimental Hematology & Oncology, 2021 RNA modification, like DNA methylation, histone modification, non-coding RNA modification and chromatin rearrangement, plays an important role in tumours.
Junchao Huang, Yingjie Shao, Wendong Gu
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The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
Nature Communications, 2020 The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway.
Junqiao Jia +7 more
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The potential role of RNA N6-methyladenosine in Cancer progression
Molecular Cancer, 2020 N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA).
Tianyi Wang +3 more
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Human ALKBH4 interacts with proteins associated with transcription. [PDF]
PLoS ONE, 2012 The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs (ALKBH1-8 and FTO). ALKBH2 and ALKBH3
Linn G Bjørnstad +5 more
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