Blood Science, 2020 . ALKBH3, a demethylase responsible for demethylating N1-methyladenosine (m1A) in mRNA and N1-methyldeoxyadenosine in single-stranded DNA, plays an important role in DNA repair and cancer cell proliferation.
Jianwei Wang
exaly +5 more sources
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA [PDF]
Cell & BioscienceBackground N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang +9 more
doaj +4 more sources
Evaluation of ALKBH2 and ALKBH3 gene regulation in patients with adult T-cell leukemia/lymphoma [PDF]
Virology JournalBackground Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus that causes malignant adult T-cell leukemia/lymphoma (ATL). Patients infected with HTLV-1 are considered HTLV-1 carriers, and a small proportion of patients progress to life ...
Yuji Wada +3 more
doaj +4 more sources
The Roles of AGTRAP, ALKBH3, DIVERSIN, NEDD8 and RRM1 in Glioblastoma Pathophysiology and Prognosis [PDF]
BiomedicinesThis study determined the expression of five novel biomarker candidates in IDH wild-type glioblastoma (GBM) tissues compared to non-malign brain parenchyma, as well as their prognostic relevance for the GBM patients’ outcomes.
Claudia Alexandra Dumitru +8 more
doaj +4 more sources
Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
doaj +4 more sources
Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAge-related macular degeneration (AMD) is a leading cause of blindness among the elderly. It is characterized by degeneration of the retinal pigment epithelium (RPE), which can develop into choroidal neovascularization (CNV) to cause severe and rapid vision loss.
Hong-Jing Zhu +2 more
exaly +5 more sources
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer [PDF]
BMC Cancer, 2017 Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson +8 more
doaj +4 more sources
A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3
Biochemistry and Biophysics Reports, 2016 Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation.
Yuko Ueda +8 more
doaj +3 more sources
ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation [PDF]
Advanced ScienceEpigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by reshaping ...
Liying Tu +9 more
doaj +2 more sources
Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB [PDF]
Molecules, 2021 Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Rui Qi +5 more
doaj +4 more sources