ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells [PDF]
Acta Pharmaceutica Sinica BChemotherapy is currently the mainstay of systemic management for triple-negative breast cancer (TNBC), but chemoresistance significantly impacts patient outcomes.
Hong-Sheng Wang
exaly +6 more sources
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA [PDF]
Cell and BioscienceBackground N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang +9 more
exaly +6 more sources
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Cell Discovery, 2022 Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Hao Jin, Jianzhao Liu, Yongxia Chang
exaly +6 more sources
PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression [PDF]
Clinical and Translational MedicineBackground RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions.
Yongxia Chang +13 more
doaj +5 more sources
Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB [PDF]
Molecules, 2021 Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Rui Qi +5 more
doaj +8 more sources
ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation [PDF]
Advanced ScienceEpigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by reshaping ...
Liying Tu +9 more
doaj +5 more sources
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A [PDF]
Nucleic Acids Research, 2023 Albeit N1-Methyladenosine (m1A) RNA modification represents an important regulator of RNA metabolism, the role of m1A modification in carcinogenesis remains enigmatic.
Ai Zhuang, Ludi Yang, Renbing Jia
exaly +5 more sources
The Roles of AGTRAP, ALKBH3, DIVERSIN, NEDD8 and RRM1 in Glioblastoma Pathophysiology and Prognosis [PDF]
BiomedicinesThis study determined the expression of five novel biomarker candidates in IDH wild-type glioblastoma (GBM) tissues compared to non-malign brain parenchyma, as well as their prognostic relevance for the GBM patients’ outcomes.
Claudia Alexandra Dumitru +8 more
doaj +5 more sources
Evaluation of ALKBH2 and ALKBH3 gene regulation in patients with adult T-cell leukemia/lymphoma [PDF]
Virology JournalBackground Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus that causes malignant adult T-cell leukemia/lymphoma (ATL). Patients infected with HTLV-1 are considered HTLV-1 carriers, and a small proportion of patients progress to life ...
Yuji Wada +3 more
doaj +5 more sources
Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
doaj +4 more sources