Results 51 to 60 of about 8,365 (191)

Can Negligible Cooperation Increase Network Reliability? [PDF]

, 2016
In network cooperation strategies, nodes work together with the aim of increasing transmission rates or reliability. This paper demonstrates that enabling cooperation between the transmitters of a two-user multiple access channel, via a cooperation ...
Effros, Michelle, Langberg, Michael, Noorzad, Parham   +2 more
core   +2 more sources

M1A and m7G modification-related genes are potential biomarkers for survival prognosis and for deciphering the tumor immune microenvironment in esophageal squamous cell carcinoma

Discover Oncology, 2023
Background Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC.
Ruixi Wang, Xingyuan Cheng, Dongmei Chi, Shiliang Liu, Qiaoqiao Li, Baoqing Chen, Mian Xi   +6 more
doaj   +1 more source

The role of m5C, m1A and m7G modifications in tumors of urinary system. [PDF]

Front Cell Dev Biol
Malignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Xue W, Zhao Y, Zhang G, Li Z, Li J, Fei X.   +5 more
europepmc   +4 more sources

m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer

Translational Oncology, 2019
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao, Qijie Zhao, Parham Jabbarzadeh Kaboli, Jing Shen, Mingxing Li, Xu Wu, Jianhua Yin, Hanyu Zhang, Yuanlin Wu, Ling Lin, Lingling Zhang, Lin Wan, Qinglian Wen, Xiang Li, Chi Hin Cho, Tao Yi, Jing Li, Zhangang Xiao   +17 more
doaj   +1 more source

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]

, 2018
The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke, Chen, Fangyi, Drennan, Catherine L., Essigmann, John M, Humulock, Zachary T., Jost, Marco, Li, Deyu, Tang, Qi, Yang, Xuedong   +8 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) [PDF]

, 2009
The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA).
Aas P. A., Abner C. W., Adhikari S., Berti P. J., Bjelland S., Chakravarti D., Delaney J. C., Delaney J. C., Dianov G., Dosanjh M. K., Eftedal I., el Ghissassi F., Elder R. H., Engelward B. P., Falnes P. O., Falnes P. O., Falnes P. O., Frick L. E., Friedberg E. C., Gallagher P. E., Goodenough A. K., Guengerich F. P., Guengerich F. P., Guengerich F. P., Guliaev A. B., Hang B., Haushalter K. A., Hitchcock T. M., Koivisto P., Kusmierek J. T., Kusmierek J. T., Lau A. Y., Lau A. Y., Leonard N. J., Ludlum D. B., Miao F., Mishina Y., Nilsen H., Ougland R., O’Brien P. J., O’Brien P. J., O’Connor T. R., O’Connor T. R., O’Neill R. J., Pearl L. H., Pendlebury A., Ringvoll J., Roy R., Samson L., Saparbaev M., Saparbaev M., Saparbaev M., Singer B., Trewick S. C., Wang H., Westbye M. P., Wuenschell G. E., Wyatt M. D.   +57 more
core   +1 more source

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

Angewandte Chemie, EarlyView.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova, Manisha B. Walunj, Claudia Höbartner   +2 more
wiley   +2 more sources

Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression

Liver Research, 2023
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate.
Jinyong He, Cuicui Xiao, Cuiping Li, Fan Yang, Cong Du   +4 more
doaj   +1 more source

Effective cosmological constant from TeV-scale physics

, 2010
It has been suggested previously that the observed cosmological constant Lambda corresponds to the remnant vacuum energy density of dynamical processes taking place at a cosmic age set by the mass scale M \sim E_{ew} of ultramassive particles with ...
Klinkhamer, F. R.
core   +1 more source