Results 61 to 70 of about 8,365 (191)

Association of m1A modification gene polymorphisms with glioma risk in Chinese children

MedComm – Oncology, 2023
Glioma is a highly heterogeneous malignancy with a high mortality rate and poor prognosis. m1A methylation modifications are associated with gliomagenesis.
Fan Liao, Rui‐Xi Hua, Xingyu Jia, Yuxiang Liao, Li Yuan, Jichen Ruan, Tianfeng Li, Zhenjian Zhuo, Jing He   +8 more
doaj   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]

, 2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan, Anderson, James T., Entian, Karl-dieter, Hauenschild, Ralf, Helm, Mark, Hildebrandt, Andreas, Jaschke, Andres, Lafontaine, Denis L.J., Motorin, Yuri, Schmid, Katharina, Sharma, Sunny, Thuring, Kathrin, Tserovski, Lyudmil, Wacheul, Ludvine, Winz, Marie-Luise   +14 more
core   +1 more source

Primordial Statistical Anisotropies: The Effective Field Theory Approach

, 2015
In this work we present the effective field theory of primordial statistical anisotropies generated during anisotropic inflation involving a background $U(1)$ gauge field.
Abolhasani, Ali Akbar, Akhshik, Mohammad, Emami, Razieh, Firouzjahi, Hassan   +3 more
core   +2 more sources

The Bipartite Structure of the tRNA m\u3csup\u3e1\u3c/sup\u3eA58 Methyltransferase from \u3cem\u3eS. cerevisiae\u3c/em\u3e is Conserved in Humans [PDF]

, 2005
Among all types of RNA, tRNA is unique given that it possesses the largest assortment and abundance of modified nucleosides. The methylation at N1 of adenosine 58 is a conserved modification, occurring in bacterial, archaeal, and eukaryotic tRNAs. In the
Andersland, Joshua, Anderson, James T., Krecic, Annette M., Ozanick, Sarah G.   +3 more
core   +1 more source

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses [PDF]

, 2014
tRNA (tRNA) is a key molecule used for protein synthesis, with multiple points of stress-induced regulation that can include transcription, transcript processing, localization and ribonucleoside base modification.
Begley, Thomas J., Dedon, Peter C., Endres, Lauren   +2 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source

Thiophene-Fused Tropones as Chemical Warfare Agent-Responsive Building Blocks [PDF]

, 2014
We report the synthesis of dithienobenzotropone-based conjugated alternating copolymers by direct arylation polycondensation. Postpolymerization modification by hydride reduction yields cross-conjugated, reactive hydroxyl-containing copolymers that ...
Bencic-Nagale S., Burnworth M., Costero A. M., Costero A. M., Dale T. J., Dale T. J., Diakowski P. M., Díaz de Greñu B., Facchetti A., Francis G. J., Gotor R., Khan M. A. K., Kowalski S., Lei Z., Meier D. C., Mercier L. G., Mlsna T. E., Pangeni D., Royo S., Schipper D. J., Song C., Steiner W. E., Sugiyasu K., Tovar J. D., Wallace K. J., Walton I., Wang F., Wang Q., Wu X., Xuan W., Zhang S.-W.   +30 more
core   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source