Results 41 to 50 of about 4,686 (145)

ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

Cell Discovery, 2022
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang, Hao Jin, Feng Yang, Xiying Chen, Jianzhao Liu, Ting Li, Yongxia Chang, Min Liu, Zhangqi Xu, Chunxiao Huo, Xiaoyi Yan, Yuehong Yang, Wei Liu, Qiang Shu, Shanshan Xie, Tianhua Zhou   +15 more
doaj   +1 more source

tRNA m¹A modification regulate HSC maintenance and self-renewal via mTORC1 signaling. [PDF]

Nat Commun
AbstractHaematopoietic stem cells (HSCs) possess unique physiological adaptations to sustain blood cell production and cope with stress responses throughout life. To maintain these adaptations, HSCs rely on maintaining a tightly controlled protein translation rate.
Zuo H, Wu A, Wang M, Hong L, Wang H.
europepmc   +4 more sources

Association of m1A modification genes polymorphisms with glioma risk in Chinese children Running head: m1A genes polymorphisms and glioma risk

, 2022
Abstract Background Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development.
Fan Liao, Rui-Xi Hua, Xingyu Jia, Yuxiang Liao, Li Yuan, Jichen Ruan, Tianfeng Li, Zhenjian Zhuo, Jing He   +8 more
openaire   +1 more source

Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes [PDF]

Communications Biology, 2020
AbstractRNA modifications affect the stability and function of RNA species, regulating important downstream processes. Modification levels are often dynamic, varying between tissues and individuals, although it is not always clear what modulates this or what impact it has on biological systems.
Aminah Tasnim Ali, Youssef Idaghdour, Alan Hodgkinson   +2 more
openaire   +3 more sources

M1ARegpred: Epitranscriptome Target Prediction of N1-methyladenosine (m1A) Regulators Based on Sequencing Features and Genomic Features

Frontiers in Bioscience-Landmark, 2022
Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators.
Jia-Hui Yao, Meng-Xian Lin, Wen-Jun Liao, Wei-Jie Fan, Xiao-Xin Xu, Haoran Shi, Shu-Xiang Wu   +6 more
doaj   +1 more source

RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma

Frontiers in Immunology, 2022
N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Meng Mao, Meng Mao, Meng Mao, Qinjun Chu, Yongli Lou, Peipei Lv, Lin-jian Wang, Lin-jian Wang, Lin-jian Wang   +8 more
doaj   +1 more source

M1A and m7G modification-related genes are potential biomarkers for survival prognosis and for deciphering the tumor immune microenvironment in esophageal squamous cell carcinoma

Discover Oncology, 2023
Background Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC.
Ruixi Wang, Xingyuan Cheng, Dongmei Chi, Shiliang Liu, Qiaoqiao Li, Baoqing Chen, Mian Xi   +6 more
doaj   +1 more source

m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer

Translational Oncology, 2019
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao, Qijie Zhao, Parham Jabbarzadeh Kaboli, Jing Shen, Mingxing Li, Xu Wu, Jianhua Yin, Hanyu Zhang, Yuanlin Wu, Ling Lin, Lingling Zhang, Lin Wan, Qinglian Wen, Xiang Li, Chi Hin Cho, Tao Yi, Jing Li, Zhangang Xiao   +17 more
doaj   +1 more source

Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression

Liver Research, 2023
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate.
Jinyong He, Cuicui Xiao, Cuiping Li, Fan Yang, Cong Du   +4 more
doaj   +1 more source

The role of m5C, m1A and m7G modifications in tumors of urinary system

Frontiers in Cell and Developmental Biology
Malignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Wei Xue, Yuanyuan Zhao, Gong Zhang, Zhiyuan Li, Jixin Li, Xiang Fei   +5 more
openaire   +4 more sources