Results 41 to 50 of about 8,365 (191)
Molecular Oncology, 2023 Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen +5 more
doaj +1 more source
De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function. [PDF]
Int J Biol SciCoronary microembolization (CME) refers to embolism in the coronary microcirculation. This study showed a reduction in succinyl transferase (CPT1A) and the succinylation substrate (succinyl-CoA) in cardiomyocytes in CME models, suppressing the succinylation of the mitochondrially localized protein TRMT10C.
Hu CK +7 more
europepmc +3 more sources
Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes [PDF]
Communications Biology, 2020 AbstractRNA modifications affect the stability and function of RNA species, regulating important downstream processes. Modification levels are often dynamic, varying between tissues and individuals, although it is not always clear what modulates this or what impact it has on biological systems.
Aminah Tasnim Ali +2 more
openaire +3 more sources
, 2022 Abstract Background Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development.
Fan Liao +8 more
openaire +1 more source
Induced Gauge Theory on a Noncommutative Space [PDF]
, 2007 We consider a scalar $\phi^4$ theory on canonically deformed Euclidean space in 4 dimensions with an additional oscillator potential. This model is known to be renormalisable.
A. Connes +18 more
core +9 more sources
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Cell Discovery, 2022 Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang +15 more
doaj +1 more source
On the Large Time Behavior of Solutions of Hamilton-Jacobi Equations Associated with Nonlinear Boundary Conditions [PDF]
, 2012 In this article, we study the large time behavior of solutions of first-order Hamilton-Jacobi Equations, set in a bounded domain with nonlinear Neumann boundary conditions, including the case of dynamical boundary conditions.
A. Davini +30 more
core +4 more sources
Frontiers in Bioscience-Landmark, 2022 Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators.
Jia-Hui Yao +6 more
doaj +1 more source
Modelling and analyzing adaptive self-assembling strategies with Maude [PDF]
, 2015 Building adaptive systems with predictable emergent behavior is a challenging task and it is becoming a critical need. The research community has accepted the challenge by introducing approaches of various nature: from software architectures, to ...
Bruni, Roberto +4 more
core +2 more sources
Frontiers in Immunology, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Meng Mao +8 more
doaj +1 more source