Results 41 to 50 of about 1,872,691 (138)
m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Cell Reports, 2022 N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Sung Ho Boo, Hongseok Ha, Yoon Ki Kim
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A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase [PDF]
Nucleic Acids Research, 2004 The modified nucleoside 1-methyladenosine (m(1)A) is found in the T-loop of many tRNAs from organisms belonging to the three domains of life (Eukaryota, Bacteria, Archaea). In the T-loop of eukaryotic and bacterial tRNAs, m(1)A is present at position 58, whereas in archaeal tRNAs it is present at position(s) 58 and/or 57, m(1)A57 being the obligatory ...
Roovers, Martine +6 more
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Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]
E3S Web of Conferences, 2020 N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
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European Journal of Medical Research, 2023 Adenosine N1 methylation (m1A) of RNA, a type of post-transcriptional modification, has been shown to play a significant role in the progression of cancer.
Linjun Zhou +3 more
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, 2022 Abstract Background Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development.
Fan Liao +8 more
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ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Cell Discovery, 2022 Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang +15 more
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Frontiers in Bioscience-Landmark, 2022 Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators.
Jia-Hui Yao +6 more
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Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes [PDF]
Communications Biology, 2020 AbstractRNA modifications affect the stability and function of RNA species, regulating important downstream processes. Modification levels are often dynamic, varying between tissues and individuals, although it is not always clear what modulates this or what impact it has on biological systems.
Aminah Tasnim Ali +2 more
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m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer
Translational Oncology, 2019 BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao +17 more
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Frontiers in Immunology, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Meng Mao +8 more
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