Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs
Nature Communications, 2019 N 1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5.
Anya V. Grozhik +5 more
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Identification and validation of an m1A-score model to predict outcomes and immunomodulation in lung squamous cell carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]
Discover OncologyLung squamous cell carcinoma (LUSC) is a common and aggressive subtype of lung cancer, characterized by difficult treatment and poor prognosis. N1-methyladenosine (m1A) is an RNA modification that plays a crucial role in various biological processes ...
Han Gong +5 more
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Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study [PDF]
Human GenomicsBackground The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang +9 more
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Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
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HeliyonN1-methyladenosine (m1A) modification is a crucial post-transcriptional regulatory mechanism of messenger RNA (mRNA) in living organisms. Few studies have focused on analysis of m1A regulators in lower-grade gliomas (LGG).
Kunjian Lei +16 more
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tRNA-m1A modification: a translational checkpoint for T cell expansion. [PDF]
Cell Res, 2023 Pei W, Kuchroo VK.
europepmc +3 more sources
Methyladenine as a regulator of biomolecular condensation [PDF]
Frontiers in Molecular BiosciencesRibonucleotide modifications modulate RNA structure and stability, thereby influencing RNA turnover and a wide range of cellular functions. Recent studies have revealed that specific RNA modifications can also affect the formation, composition, and ...
Roberto Arsiè +2 more
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The m1A modification of tRNAs: a translational accelerator of T-cell activation. [PDF]
Cell Mol Immunol, 2022 Chen C, Ye L.
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ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation [PDF]
Clinical and Translational MedicineBackground Myocardial ischemia/reperfusion (I/R) injury induces an intense inflammatory response and involves multiple cell death pathways. PANoptosis, an integrated cell death process involving pyroptosis, apoptosis and necroptosis, is a major driver of
Hongtao Diao +14 more
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