Results 21 to 30 of about 1,872,691 (138)

M1A and m7G modification-related genes are potential biomarkers for survival prognosis and for deciphering the tumor immune microenvironment in esophageal squamous cell carcinoma

Discover Oncology, 2023
Background Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC.
Ruixi Wang, Xingyuan Cheng, Dongmei Chi, Shiliang Liu, Qiaoqiao Li, Baoqing Chen, Mian Xi   +6 more
doaj   +2 more sources

TRMT6‐Mediated m1A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science
Hepatocellular carcinoma (HCC) is a leading cause of death worldwide, with hepatitis B virus (HBV) infection being the major risk factor. Dysregulation of mRNA methylation contributes to tumorigenesis and virus replication. However, the association of N1‐
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
doaj   +2 more sources

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Radioresistance remains a major obstacle to the curative treatment of hepatocellular carcinoma (HCC). While cuproptosis represents a potential strategy to eliminate resistant cells, the epitranscriptomic mechanisms underlying cuproptosis evasion ...
Yun-Yun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yan-Ling Wen, Yi-Bing Pan, Chen Lin, Junguo Bu, Li-Bing Song, Hui Dai   +10 more
semanticscholar   +2 more sources

M1A Regulator-Mediated Methylation Modification And Gene Signatures And Their Prognostic Value In Multiple Myeloma [PDF]

, 2022
Introduction: N1‑methyladenosine (m1A), a methylation modification on RNA, is gaining attention for its role across diverse biological processes. However, the potential roles of m1A regulator-mediated methylation modification in multiple myeloma (MM ...
Jia Fu, Xingjun Han, Wei-Long Gao, Jinwei Cui, Ma Yu, X. Cui   +5 more
semanticscholar   +2 more sources

tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling

Nature Communications
Haematopoietic stem cells (HSCs) possess unique physiological adaptations to sustain blood cell production and cope with stress responses throughout life.
Hongna Zuo, Aiwei Wu, Mingwei Wang, Liquan Hong, Hu Wang   +4 more
semanticscholar   +4 more sources

THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network

Frontiers in Genetics
m1A modification, as a pivotal RNA epigenetic modification, plays a central regulatory role in the pathogenesis and progression of complex human diseases, including cancer.
Hongyan Gao, Xue Zhou, Lei Bai, Haifeng Yang, Fei Liu   +4 more
doaj   +2 more sources

Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study

Human Genomics
Background The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang, Lei Lin, Wenli Zhang, Jiliang Yang, Mengzhen Zhang, Huimin Yin, Xinxin Zhang, Chunlei Zhou, Yan Zou, Jing He   +9 more
doaj   +2 more sources

Advances in the Structural and Functional Understanding of m1A RNA Modification

Accounts of Chemical Research
Conspectus RNA modification is a co- or post-transcriptional process by which specific nucleotides are chemically altered by enzymes after their initial incorporation into the RNA chain, expanding the chemical and functional diversity of RNAs.
Jakub Smoczynski, Marcel-Joseph Yared, Vincent Meynier, P. Barraud, C. Tisné   +4 more
semanticscholar   +3 more sources

tRNA m1A modification ensures HSPC production via modulating Nrf1 translation in zebrafish

EMBO Reports
During embryogenesis, nascent hematopoietic stem and progenitor cells (HSPCs) arise from hemogenic endothelium via endothelial-to-hematopoietic transition (EHT).
Zhenkun Dong, Panfeng Li, Mengyao Liu, Sifeng Wang, Weiyi Lai, Yining Liu, Hailin Wang, Ang Li, Lu Wang   +8 more
semanticscholar   +2 more sources

The m1A modification of tRNAs: a translational accelerator of T-cell activation

Cellular & Molecular Immunology, 2022
Cheng-Li Chen, L. Ye
semanticscholar   +3 more sources