Results 71 to 80 of about 1,872,691 (138)

m6A/ m1A /m5C/m7G-related methylation modification patterns and immune characterization in prostate cancer

Frontiers in Pharmacology, 2022
Methylation has a close relationship with immune reactions, metastasis, and cancer cell growth. Additionally, RNA methylation-related proteins have emerged as potential cancer therapeutic targets.
Xinhong Ye, Ruyi Wang, Xiaoqian Yu, Zili Wang, Hai-feng Hu, HanChao Zhang   +5 more
semanticscholar   +1 more source

Clinical Application of the SAMEO‐ATO Classification and Analysis of the Correlation Between Individual Subgroups and Surgery Duration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Tympanomastoid surgery, encompassing intricate middle ear and mastoid procedures, necessitates a standardized classification system to ensure consistent documentation, enhance comparability, and improve outcome analysis across different clinical settings.
Julia van de Loo, Naledi Jankowski, Marcel Mayer, Hans Eckel, Louis Jansen, Helen Abing, Anne Nobis, Johannsen Jannik, Jens Peter Klußmann, Jan Christoffer Lüers   +9 more
wiley   +1 more source

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

The Naturally Occurring m1A RNA Modification Can Be Efficiently Incorporated into RNA by SARS-CoV-2 RdRp

, 2023
Abstract When it is in the template RNA, the naturally occurring m1A epitranscriptomic RNA modification was recently reported to be able to stop the RNA polymerization reaction catalyzed by the RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. In this report, we report that m1A via its triphosphate form (m1ATP) can be incorporated into RNA by ...
Alexander Apostle, Reed Arneson, Yinan Yuan, Shiyue Fang   +3 more
openaire   +1 more source

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
doaj   +1 more source

Neuroimaging and neurophysiology in infantile‐onset epilepsy after neonatal stroke

Developmental Medicine &Child Neurology, EarlyView.
This population‐based retrospective cohort study of 55 newborn infants demonstrated that neonatal MRI and neonatal neurophysiology (amplitude‐integrated EEG, conventional EEG, and somatosensory evoked potentials) combined with follow‐up EEGs during the first year of life provide practical tools for identifying infants at the highest risk of developing ...
Sinikka La Grassa, Kirsi Mikkonen, Marjo Metsäranta, Sanna Toiviainen‐Salo, Sampsa Vanhatalo, Leena Lauronen, Päivi Nevalainen   +6 more
wiley   +1 more source

Enrichment‐Based Duplex PCR for Early Detection of Potentially Virulent Vibrio harveyi in Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Vibrio harveyi is an important bacterial pathogen in marine aquaculture, responsible for outbreaks affecting a wide range of fish species. Early detection of potentially virulent isolates in fish and environmental samples is essential for effective disease prevention and management, particularly under field conditions where the pathogen may be
Javier Barriga‐Cuartero, Carla Hernández‐Cabanyero, Pablo Ibanyez‐Paya, Carmen Amaro, Belen Fouz   +4 more
wiley   +1 more source

Harnessing Star Power: The Distinct Effects of Star Inventors on Radical and Incremental Innovation

Journal of Management Studies, EarlyView.
Abstract Star inventors are highly valuable resources, offering scarce knowledge and expertise that significantly enhance a firm's innovation performance. Beyond their expertise, what sets star inventors apart is their star status – a role that prescribes them high positions in organizational hierarchy and the power to steer resource allocation within ...
Murod Aliyev, Hyungseok David Yoon
wiley   +1 more source

m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma

Experimental and Therapeutic Medicine
N1-methyladenosine (m1A), a methylation of RNA, is gaining attention for its role in diverse biological processes. However, the potential roles of m1A regulatory-mediated methylation modifications in multiple myeloma (MM) remain unclear. The mRNA expression of m1A regulators in normal plasma (NP; n=9) and MM (n=174) bone marrow plasma cells was ...
Fu, Jiaqi, Han, Xingjun, Gao, Wei, Yu, Manya, Cui, Xing   +4 more
openaire   +2 more sources