Results 91 to 100 of about 4,686 (145)

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

Dinoflagellate mRNA is pervasively modified with m1A

EMBO Reports
N 1-methyladenosine (m1A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression.
Jianheng Fox Liu, Samie R Jaffrey
doaj   +1 more source

Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications

Parasites & Vectors
Abstract Background Chemical modifications of mRNAs constitute an alternative mechanism for gene expression regulation, which involves proteins responsible for adding, recognizing and removing these modifications.
Angela Moreira, Bezerra, Ariely Barbosa, Leite, Christian Robson, de Souza Reis, João Luiz, de Lemos Padilha Pitta, Suellen Rodrigues, Maran, Nilmar Silvio, Moretti, Danielle Maria Nascimento, Moura, Antonio Mauro, Rezende   +7 more
openaire   +2 more sources

Development of a novel disulfidptosis-correlated m6A/m1A/m5C/m7G gene signature to predict prognosis and therapeutic response for lung adenocarcinoma patients by integrated machine-learning

Discover Oncology
Background Lung adenocarcinoma (LUAD) represents a significant global health burden, necessitating advanced prognostic tools for improved patient management.
Bilin Xu, Liangyu Zhang, Lijie Lin, Yanfeng Lin, Fancai Lai   +4 more
doaj   +1 more source

tRNA-m1A Modification Safeguards Fetal Liver HSPCs from DNA Damage via Maintaining Iron Homeostasis

Blood Journal
Hematopoietic stem and progenitor cell (HSPC) development requires finely tuned gene expression programs, yet the role of tRNA modifications in this process remains largely unknown. Here, we uncover the essential function of the tRNA methyltransferase Trmt61a in sustaining fetal liver (FL) HSPCs through N1-methyladenosine (m¹A) deposition.
Yining Liu, Yichen Ma, Panfeng Li, Yongjie Li, Guixian Liang, Xiaoting Zhang, Baofeng Huang, Jinying Peng, Dongyuan Ma, Lu Wang, Ang Li, Chengqi Yi, Feng Liu   +12 more
openaire   +1 more source

Advances in the Structural and Functional Understanding of m1A RNA Modification

RNA modification is a co-or post-transcriptional process by which specific nucleotides are chemically altered by enzymes after their initial incorporation into the RNA chain, expanding the chemical and functional diversity of RNAs. Our understanding of RNA modifications has changed dramatically in recent years.
Smoczynski, Jakub, Yared, Marcel-Joseph, Meynier, Vincent, Barraud, Pierre, Tisné, Carine   +4 more
openaire   +1 more source

Author response: The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

, 2023
Mengfan Hou, Xianfu Yi, Chi Zhang, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
openaire   +1 more source

Quantification of tRNA m¹A modification by templated-ligation qPCR. [PDF]

RNA
Zhang W, Chen H, Sobczyk M, Krochmal D, Katanski CD, Assari M, Chen A, Hou Y, Dai Q, Pan T.   +9 more
europepmc   +1 more source

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation. [PDF]

J Cell Commun Signal
Li N, Zhang H.
europepmc   +1 more source

Editor's evaluation: The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

, 2023
openaire   +1 more source