Results 91 to 100 of about 1,872,691 (138)

Comprehensive Pan‐Cancer Analysis of ABCA1: Insights From Multi‐Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma

open access: yesCell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Cancer remains a major cause of global mortality, necessitating the identification of novel biomarkers to improve prognosis and guide therapy. ABCA1, an ATP‐binding cassette transporter involved in cholesterol efflux, has been implicated in tumorigenesis, yet its pan‐cancer roles and clinical relevance are not fully understood.
Chenyang Wang   +16 more
wiley   +1 more source

Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects

open access: yesCell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.
Minjuan Du, Leisheng Wang
wiley   +1 more source

Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine

open access: yesEMBO Reports
A major goal in epitranscriptomics is to define the diversity of modified nucleotides in mRNA. Most candidate sites are discovered using transcriptome-wide mapping methods that rely on antibody enrichment or modification-induced misincorporations during ...
Rohit Nalavade   +2 more
doaj   +1 more source

Prediction of the individual risk for the development of brain metastases in patients with non‐oncogene‐addicted non‐small cell lung cancer: Real‐world data from the German prospective CRISP registry (AIO‐TRK‐0315)

open access: yesInternational Journal of Cancer, Volume 159, Issue 3, Page 739-749, 1 August 2026.
What's New? Estimating the risk of developing brain metastases may enable earlier diagnosis and treatment, potentially reducing morbidity and mortality. Using the prospective CRISP lung cancer registry, the authors developed and validated a point‐based classifier for the risk of developing first brain metastases in patients with advanced or metastatic ...
Fabian Acker   +207 more
wiley   +1 more source

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report

open access: yesBipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objectives Three clinical staging models for bipolar disorder (BD) have been published, each with a different but complementary approach and focus. The International Society for Bipolar Disorders Staging Task Force aimed to integrate these models into one comprehensive three‐dimensional staging model, separately rating bipolar spectrum ...
Ralph Kupka   +27 more
wiley   +1 more source

AP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids

open access: yesBiology of the Cell, Volume 118, Issue 8, August 2026.
We show that in mouse intestinal organoids, AP‐1B is implicated in apical polarity, differentiation in the secretory lineage and proliferation. In particular, we propose that proliferation is controlled by AP‐1B via the mTOR and YAP pathways. Arrows show the functional links that were elucidated in this study, and dotted lines show putative downstream ...
Maela Duclos   +5 more
wiley   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

open access: yesAdvanced Science
Mitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li   +13 more
doaj   +1 more source

Examining the efficacy of a sanctuary to protect sharks in the Galapagos Marine Reserve

open access: yesConservation Science and Practice, Volume 8, Issue 8, August 2026.
Abstract In 2016, Ecuador established a no‐take marine sanctuary in the northern portion of the Galapagos Marine Reserve (GMR), ostensibly to protect sharks. Arguably because of this, experimental longlining was permitted in the rest of the reserve as part of a compensation package to local fishers. Considering this agreement and very low bycatch rates
Leah R. Gerber   +3 more
wiley   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

open access: yesInternational Journal of Applied Linguistics, Volume 36, Issue 3, Page 2298-2308, August 2026.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes

open access: yesScientific Reports, 2018
The entire chemical modification repertoire of yeast ribosomal RNAs and the enzymes responsible for it have recently been identified. Nonetheless, in most cases the precise roles played by these chemical modifications in ribosome structure, function and ...
Sunny Sharma   +7 more
doaj   +1 more source

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