Results 91 to 100 of about 1,872,691 (138)
Comprehensive Pan‐Cancer Analysis of ABCA1: Insights From Multi‐Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma
Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.ABSTRACT
Cancer remains a major cause of global mortality, necessitating the identification of novel biomarkers to improve prognosis and guide therapy. ABCA1, an ATP‐binding cassette transporter involved in cholesterol efflux, has been implicated in tumorigenesis, yet its pan‐cancer roles and clinical relevance are not fully understood.Chenyang Wang, Hanbing Wang, Xi Chen, Yingying Liu, Lili Duan, Zhenshun Li, Liaoran Niu, Aqiang Fan, Siyu Wei, Han Bai, Yujie Zhang, Wei Zhou, Jinqiang Liu, Wanli Yang, Yu Han, Liu Hong, Daiming Fan +16 morewiley +1 more sourceEpigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects
Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.ABSTRACT
Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.Minjuan Du, Leisheng Wangwiley +1 more sourcePrediction of the individual risk for the development of brain metastases in patients with non‐oncogene‐addicted non‐small cell lung cancer: Real‐world data from the German prospective CRISP registry (AIO‐TRK‐0315)
International Journal of Cancer, Volume 159, Issue 3, Page 739-749, 1 August 2026.What's New?
Estimating the risk of developing brain metastases may enable earlier diagnosis and treatment, potentially reducing morbidity and mortality. Using the prospective CRISP lung cancer registry, the authors developed and validated a point‐based classifier for the risk of developing first brain metastases in patients with advanced or metastatic ...Fabian Acker, Katharina Wenger, Martin Reck, Cornelius F. Waller, Petra Hoffknecht, Andre Bethge, Arnd Nusch, Marcel Reiser, Christiane Bernhardt, Michael Bendel, Carolin Lennartz, Annette Fleitz, Martina Jänicke, Paula Ludwig, Annika Groth, Frank Griesinger, Michael Thomas, Wilfried E. E. Eberhardt, Martin Sebastian, for the CRISP Registry Group, Juliana Ababei, Jürgen Alt, Andreas Ammon, Sven Philip Aries, Akin Atmaca, Ivo Azeh, Eva‐Maria Barkowsky, Stefan Bauer, Silvan Becker, Dirk Behringer, Michael Bendel, Robin Benkelmann, Veronika Berberich, André Bethge, Annalen Bleckmann, Michael Boesche, Sabine Bohnet, Harald‐Robert Bruch, Wolfgang Brückl, Ulrike Burkhard‐Meier, Dieter Bürkle, Daniel C. Christoph, Petros Christopoulos, Peter Czyborra, Klaus‐Ulrich Däßler, Maike de Wit, Tobias Dechow, Reinhard Depenbusch, Karl‐Matthias Deppermann, Nicolas Dickgreber, Lutz Dietze, Markus Dommach, Steffen Dörfel, Wilfried Eberhardt, Ekkehard Eigendorff, Corinna Elender, Wolfgang Elsel, Till‐Oliver Emde, Bastian Eul, Martin Faehling, Florian Fauth, Thomas Fietz, Dimitri Flieger, Helmut Forstbauer, Werner Freier, Christian Frenzel, Florian Fuchs, Roswitha Fuchs, Thomas Fühner, Tobias Gaska, Wolfgang Gleiber, Tobias Graefe, Ullrich Graeven, Christian Grah, Sibylle Greiner, Frank Griesinger, Christian Grohé, Matthias Groschek, Carolin Groß‐Ophoff‐Müller, Andreas Günther, Sylvia Gütz, Siegfried Haas, Matthias Hackenthal, Volker Hagen, Carla Verena Hannig, Richard Hansen, Andrea Heider, David Heigener, Kathrin Heinrich, Natalia Heinz, Christiane Hering‐Schubert, Jörg Heßling, Conrad Heuchel, Petra Hoffknecht, Patricia Hortig, Gerdt Hübner, Horst‐Dieter Hummel, Ulrich Hutzschenreuter, Gerald Illerhaus, Thomas Illmer, Georg Innig, Melanie Janning, Jan Janssen, Christian Junghanß, Christian Kaes, Ulrich Kaiser, Stefan Kaldune, Haytham Kamal, Kato Kambartel, Lale Kayikci, Jens Kern, Dorothea Kingreen, Ortwin Klein, Konrad Kokowski, Wolfgang Körber, Dirk Koschel, Benoit Krämer, Beate Krammer‐Steiner, Jonas Kuon, Eckart Laack, Christof Lamberti, Markus Lehmann, Rumo David Leistner, Rüdiger Liersch, Hartmut Linde, Migle Link, Jörg Lipke, Verena Luber, Andreas Lück, Gita Maher, Kerstin Martin, Martin Metzenmacher, Christian Meyerzum Büschenfelde, Philipp Meyn, Enno Moorahrend, Christian Mozek, Annette Müller, Lothar Müller, Michael Neise, Holger Nückel, Arnd Nusch, Tobias Overbeck, Matthias Paland, Henning Pelz, Volker Petersen, Bettina Peuser, Christian Plate, Margarete Plath, Stefan Pluntke, Munir Rababah, Martin Reck, Niels Reinmuth, Marcel Reiser, Roland Repp, Daniel Reschke, Achim Rittmeyer, Yolanda Rodemer, Georg Rußwurm, Parvis Sadjadian, Reiner Sandner, Annette Sauer, Harald Schäfer, Clemens Schiefer, Burkhard Schmidt, Stephan Schmitz, Folker Schneller, Jan Schröder, Gunter Schuch, Christoph Schulz, Christian Schulz, Mathias Schulze, Christian Schumann, Wolfgang Schütte, Martin Schwaiblmair, Marcus Schweigert, Peter Florian Schwindt, Martin Sebastian, Bernd Seese, Gernot Seipelt, Christoph Sick, Theodoros Skentos, Thomas Sorgenfrei, Axel Stang, Johannes Steiff, Heike Steiniger, Susanne Stetter, Runa Stiegler, Heidrun Stumme, Amanda Tufman, Jens Uhlig, Ursula Vehling‐Kaiser, Gunther Vogel, Eyck von der Heyde, Oliver Waidmann, Cornelius F. Waller, Georg Weißenborn, Florian Weißinger, Martin Wermke, Claas Wesseler, Jörg Wiegand, Ute Wieschermann, Stefan Wilhelm, Jochen Wilke, Mark‐Oliver Zahn, Matthias Zaiss, Matthias Zeth, Joachim Zimber, Björn Schöttker +207 morewiley +1 more sourceTowards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Objectives
Three clinical staging models for bipolar disorder (BD) have been published, each with a different but complementary approach and focus. The International Society for Bipolar Disorders Staging Task Force aimed to integrate these models into one comprehensive three‐dimensional staging model, separately rating bipolar spectrum ...Ralph Kupka, Danella Hafeman, Madeleine McCallum, Afra van der Markt, Hailey Tremain, Martin Alda, Jorge Almeida, Taiane de Azevedo Cardoso, Vicent Balanzá‐Martínez, Boris Birmaher, David J. Bond, Elisa Brietzke, Ines Chendo, Iria Grande, Tomas Hajek, Manon Hillegers, Marcia Kauer‐Sant'Anna, Rodrigo Mansur, Ives Cavalcante Passos, Ana Gonzalez Pinto, Robert Post, Mauricio Tohen, Gustavo Vazquez, Eduard Vieta, Lakshmi N. Yatham, Flávio Kapczinski, Michael Berk, Anne Duffy +27 morewiley +1 more sourceAP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids
Biology of the Cell, Volume 118, Issue 8, August 2026.We show that in mouse intestinal organoids, AP‐1B is implicated in apical polarity, differentiation in the secretory lineage and proliferation. In particular, we propose that proliferation is controlled by AP‐1B via the mTOR and YAP pathways. Arrows show the functional links that were elucidated in this study, and dotted lines show putative downstream ...Maela Duclos, Anne Bourdais, Ophélie Nicolle, Alexandre Helpiquet, Grégoire Michaux, Aurélien Bidaud‐Meynard +5 morewiley +1 more sourceSite‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li +13 moredoaj +1 more sourceExamining the efficacy of a sanctuary to protect sharks in the Galapagos Marine Reserve
Conservation Science and Practice, Volume 8, Issue 8, August 2026.Abstract
In 2016, Ecuador established a no‐take marine sanctuary in the northern portion of the Galapagos Marine Reserve (GMR), ostensibly to protect sharks. Arguably because of this, experimental longlining was permitted in the rest of the reserve as part of a compensation package to local fishers. Considering this agreement and very low bycatch rates Leah R. Gerber, Alex R. Hearn, Camila Guerrero Pineda, E. Paola Sangolquí +3 morewiley +1 more sourceA single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes
Scientific Reports, 2018 The entire chemical modification repertoire of yeast ribosomal RNAs and the enzymes responsible for it have recently been identified. Nonetheless, in most cases the precise roles played by these chemical modifications in ribosome structure, function and ...Sunny Sharma, Johannes David Hartmann, Peter Watzinger, Arvid Klepper, Christian Peifer, Peter Kötter, Denis L. J. Lafontaine, Karl-Dieter Entian +7 moredoaj +1 more source