Results 41 to 50 of about 26,465 (226)
Effect of M1a and M1b Category in Metastatic Colorectal Cancer [PDF]
The Oncologist, 2014 Abstract Background. In 2009, the American Joint Committee on Cancer version 7 staging system introduced the M1 subclassifications M1a (single metastatic site) and M1b (peritoneal or multiple metastatic sites). The study objectives were to evaluate the prognostic effect of site of metastasis and M1a/b
Hagen, Kennecke +6 more
openaire +2 more sources
MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
Cancer Medicine, 2022 AbstractBackgroundDistant metastasis is the main cause of mortality in colorectal cancer (CRC) patients. N1‐methyladenosine (m1A) is a type of epitranscriptome modification. While its regulatory effect on mRNA and its role in CRC metastasis remain unclear.MethodsThe m1A methylation profile of mRNAs in CRC was revealed by m1A methylated RNA ...
Meng Xue +6 more
openaire +3 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Orientifold's Landscape: Non-Factorisable Six-Tori
, 2007 We construct type IIA orientifolds on T6/(Z2 x Z2) which admit non factorisable lattices. We describe a method to deal with this kind of configurations and discuss how the compactification lattice affects the tadpole cancellation conditions. Moreover, we
Forste, Stefan +2 more
core +1 more source
Rubisco evolution in C4 eudicots: an analysis of Amaranthaceae sensu lato [PDF]
, 2015 BACKGROUND Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) catalyses the key reaction in the photosynthetic assimilation of CO₂. In C₄ plants CO₂ is supplied to Rubisco by an auxiliary CO₂-concentrating pathway that helps to maximize the ...
Filatov, Dmitry A. +2 more
core +1 more source
Radical‐Based On‐Surface Transformation of Nonplanar Aromatics Into Nonbenzenoid Nanographenes
Angewandte Chemie, EarlyView.Formation of radicals in nonplanar hydrocarbons through thermally induced dehydrogenation leads to molecular transformation via intramolecular radical‐based cyclization and dimerization, leading to formation of nonbenzenoid nanographenes. ABSTRACT On‐surface synthesis has emerged as a powerful tool for atomically precise C─C bond formation, enabling ...
Daniel Rothhardt +8 more
wiley +2 more sources
Does nonaxisymmetric dynamo operate in the Sun?
, 2018 We explore effects of random non-axisymmetric perturbations of kinetic helicity (the $\alpha$ effect) and diffusive decay of bipolar magnetic regions on generation and evolution of large-scale non-axisymmetric magnetic fields on the Sun.
Kosovichev, A. G., Pipin, V. V.
core +1 more source
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, EarlyView.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources
The Bipartite Structure of the tRNA m\u3csup\u3e1\u3c/sup\u3eA58 Methyltransferase from \u3cem\u3eS. cerevisiae\u3c/em\u3e is Conserved in Humans [PDF]
, 2005 Among all types of RNA, tRNA is unique given that it possesses the largest assortment and abundance of modified nucleosides. The methylation at N1 of adenosine 58 is a conserved modification, occurring in bacterial, archaeal, and eukaryotic tRNAs. In the
Andersland, Joshua +3 more
core +1 more source
Primordial Statistical Anisotropies: The Effective Field Theory Approach
, 2015 In this work we present the effective field theory of primordial statistical anisotropies generated during anisotropic inflation involving a background $U(1)$ gauge field.
Abolhasani, Ali Akbar +3 more
core +2 more sources