Results 41 to 50 of about 13,010 (203)

The m6A/m1A/m5C-Related Methylation Modification Patterns and Immune Landscapes in Rheumatoid Arthritis and Osteoarthritis Revealed by Microarray and Single-Cell Transcriptome

Journal of Inflammation Research, 2023
Haishi Zheng,1,2 Yirixiati Aihaiti,2 Yongsong Cai,2 Qiling Yuan,2 Mingyi Yang,2 Zheng Li,2 Ke Xu,2 Peng Xu1,2 1Department of Orthopedics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Joint ...
Zheng H, Aihaiti Y, Cai Y, Yuan Q, Yang M, Li Z, Xu K, Xu P   +7 more
doaj  

Image_4_Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma.tif

, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Yifang Xiang (12698255), Xiaojiao Guan (8620668), Guangyao Bao (12693677), Tian Li (194773), Yao Yao (335996), Jie Liang (37016), Xinwen Zhong (12693680)   +6 more
core   +1 more source

N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction

Cell Death Discovery, 2023
N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress.
Zhangyang Qi, Chi Zhang, Huan Jian, Mengfan Hou, Yongfu Lou, Yi Kang, Wei Wang, Yigang Lv, Shenghui Shang, Chaoyu Wang, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +1 more source

Image_2_Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma.tif

, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Yifang Xiang (12698255), Xiaojiao Guan (8620668), Guangyao Bao (12693677), Tian Li (194773), Yao Yao (335996), Jie Liang (37016), Xinwen Zhong (12693680)   +6 more
core   +1 more source

Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer’s disease

Human Molecular Genetics, 2021
AbstractRNA modifications affect many aspects of RNA metabolism and are involved in the regulation of many different biological processes. Mono-methylation of adenosine in the N1 position, N1-methyladensoine (m1A), is a reversible modification that is known to target rRNAs and tRNAs.
Andrew M Shafik, Huiqing Zhou, Junghwa Lim, Bryan Dickinson, Peng Jin   +4 more
openaire   +2 more sources

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Angewandte Chemie, EarlyView.
The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch, Yitzhak Tor, Claudia Höbartner   +2 more
wiley   +2 more sources

Effect of Lymph Node Metastasis on Prognosis of Small Cell Lung Cancer with M1a Disease: A Study Based on SEER database

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the impact of lymph node metastasis on the survival of SCLC patients with M1a disease. Methods We retrospectively analyzed the medical records of 7027 SCLC patients with M1a disease from 2004 to 2015 in SEER database.
YANG Hao, MEI Tonghua
doaj   +1 more source

Image_1_Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma.tif

, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Yifang Xiang (12698255), Xiaojiao Guan (8620668), Guangyao Bao (12693677), Tian Li (194773), Yao Yao (335996), Jie Liang (37016), Xinwen Zhong (12693680)   +6 more
core   +1 more source

m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. [PDF]

, 2023
Microsatellite repeat expansions within genes contribute to a number of neurological diseases1,2. The accumulation of toxic proteins and RNA molecules with repetitive sequences, and/or sequestration of RNA-binding proteins by RNA molecules containing ...
Gonzalez, Gwendolyn, Bonini, Nancy, Wang, Nan, Yuan, Jun, Gu, Weifeng, Dai, Hui, Cui, Yuxiang, Dai, Xiaoxia, Yang, X, Tang, Feng, Perlegos, Alexandra, Yin, Jiekai, Liu, Xiaochuan, Sun, Yuxiang, Wang, Yinsheng   +14 more
core   +1 more source

Image_3_Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma.tif

, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Yifang Xiang (12698255), Xiaojiao Guan (8620668), Guangyao Bao (12693677), Tian Li (194773), Yao Yao (335996), Jie Liang (37016), Xinwen Zhong (12693680)   +6 more
core   +1 more source