Results 61 to 70 of about 11,313 (179)

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Nature Communications, 2022
RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su, Ida Monshaugen, Briana Wilson, Fengbin Wang, Arne Klungland, Rune Ougland, Anindya Dutta   +6 more
doaj   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia

Biomolecules & Biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
doaj   +1 more source

N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Nature Communications, 2021
Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases ...
Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, Dan Dominissini, Lei He, Yong Tian, Chengqi Yi, Zusen Fan   +12 more
doaj   +1 more source

Neuroimaging and neurophysiology in infantile‐onset epilepsy after neonatal stroke

Developmental Medicine &Child Neurology, EarlyView.
This population‐based retrospective cohort study of 55 newborn infants demonstrated that neonatal MRI and neonatal neurophysiology (amplitude‐integrated EEG, conventional EEG, and somatosensory evoked potentials) combined with follow‐up EEGs during the first year of life provide practical tools for identifying infants at the highest risk of developing ...
Sinikka La Grassa, Kirsi Mikkonen, Marjo Metsäranta, Sanna Toiviainen‐Salo, Sampsa Vanhatalo, Leena Lauronen, Päivi Nevalainen   +6 more
wiley   +1 more source

ALKBH1‐mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression

Molecular Oncology, 2023
Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen, Hao Wang, Shuyi Mi, Liming Shao, Zhipeng Xu, Meng Xue   +5 more
doaj   +1 more source

Enrichment‐Based Duplex PCR for Early Detection of Potentially Virulent Vibrio harveyi in Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Vibrio harveyi is an important bacterial pathogen in marine aquaculture, responsible for outbreaks affecting a wide range of fish species. Early detection of potentially virulent isolates in fish and environmental samples is essential for effective disease prevention and management, particularly under field conditions where the pathogen may be
Javier Barriga‐Cuartero, Carla Hernández‐Cabanyero, Pablo Ibanyez‐Paya, Carmen Amaro, Belen Fouz   +4 more
wiley   +1 more source

Comprehensive analyses of m1A regulator-mediated modification patterns determining prognosis in lower-grade glioma (running title: m1A in LGG)

Heliyon
N1-methyladenosine (m1A) modification is a crucial post-transcriptional regulatory mechanism of messenger RNA (mRNA) in living organisms. Few studies have focused on analysis of m1A regulators in lower-grade gliomas (LGG). We employed the Nonnegative Matrix Factorization (NMF) technique on The Cancer Genome Atlas (TCGA) dataset to categorize LGG ...
Kunjian Lei, Yilei Sheng, Min Luo, Junzhe Liu, Chuandong Gong, Shigang Lv, Wei Tu, Minhua Ye, Miaojing Wu, Bing xiao, Hua Fang, Haitao Luo, Xinjun Liu, Xiaoyan Long, Xingen Zhu, Kai Huang, Jingying Li   +16 more
openaire   +3 more sources

Harnessing Star Power: The Distinct Effects of Star Inventors on Radical and Incremental Innovation

Journal of Management Studies, EarlyView.
Abstract Star inventors are highly valuable resources, offering scarce knowledge and expertise that significantly enhance a firm's innovation performance. Beyond their expertise, what sets star inventors apart is their star status – a role that prescribes them high positions in organizational hierarchy and the power to steer resource allocation within ...
Murod Aliyev, Hyungseok David Yoon
wiley   +1 more source

Everyday Stressors and Sense of Purpose: The Role of Stressor‐Related Opportunities for Goal Pursuit

Journal of Personality, EarlyView.
ABSTRACT Objective This study examined whether everyday stressor occurrence is associated with lower sense of purpose, and whether this association depends on stressor‐related goal opportunities, the Big Five personality traits, or trait purpose. Methods Data came from the Daily Experiences and Health Study (N = 236, ages 25–87).
Mart Visser, Lydia Q. Ong, Anita DeLongis, Patrick L. Hill, Nancy L. Sin, Patrick Klaiber   +5 more
wiley   +1 more source