Results 81 to 90 of about 14,453 (241)

The joint role of methylation and immune-related lncRNAs in ovarian cancer: Defining molecular subtypes and developing prognostic signature

Translational Oncology, 2023
Introduction: Complex outcome of ovarian cancer (OC) stems from the tumor immune microenvironment (TIME) influenced by genetic and epigenetic factors. This study aimed to comprehensively explored the subclasses of OC through lncRNAs related to both N6 ...
Kefei Gao, Wenqin Lian, Rui Zhao, Weiming Huang, Jian Xiong   +4 more
doaj   +1 more source

m¹A-Dependent TRMT6/61A-ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment. [PDF]

Adv Sci (Weinh)
Cellular senescence, a fundamental hallmark of aging, plays a paradoxical, often pro‐tumorigenic role in cancer. This malignancy is largely driven by the senescence‐associated secretory phenotype (SASP), yet the mechanisms that govern the production of a
Li T, Huang M, Cai J, Li X, Xing Y, He R, Wan Z, Gan Y, Li Z, Weng J, Xie Y, Wu Y, Liu X, Wang X, Luo Y, Huang M, Lin J, Yu H.   +17 more
europepmc   +2 more sources

ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression

Hematology
SUMMARY To investigate the role of ALKBH3 in acute myeloid leukemia (AML), we constructed an animal model of xenotransplantation of AML. Our study demonstrated that ALKBH3-mediated m1A demethylation inhibits ferroptosis in KG-1 cells by increasing ATF4 ...
Xin Liu, Xinghua Pan
semanticscholar   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, EarlyView.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, EarlyView.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

Identification of m6A/m5C/m1A-associated LncRNAs for prognostic assessment and immunotherapy in pancreatic cancer

Scientific Reports, 2023
Methylation of RNA plays an important role in cancer. Classical forms of such modifications include N6-methyladenine (m6A), 5-methylcytosine (m5C), and N1-methyladenine (m1A).
Yuquan Huang, Wu Zhang, Qingxia Li, Zhe Wang, Xianghong Yang   +4 more
semanticscholar   +1 more source

ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

Cell Discovery, 2022
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang, Hao Jin, Feng Yang, Xiying Chen, Jianzhao Liu, Ting Li, Yongxia Chang, Min Liu, Zhangqi Xu, Chunxiao Huo, Xiaoyi Yan, Yuehong Yang, Wei Liu, Qiang Shu, Shanshan Xie, Tianhua Zhou   +15 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Image_2_N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization.png [PDF]

, 2022
ObjectivesThis study aimed to identify key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. Furthermore, we aimed to explore the mechanism that m1A regulators modulate the functions of certain immune cells
Yihao Wu (9522587), Fanxing Yin (12237227), Xiaoxu Zhang (1422019), Jian Zhang (1682), Panpan Guo (1789840), Yanshuo Han (3526301), Deying Jiang (12521338), Shuixin Li (12521341), Dittmar Böckler (3447086), Ce Bian (4889614), Yuhan Yin (12521344), Chen Chen (6544), Hao Zhang (15339)   +12 more
core   +1 more source

tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling

Nature Communications
Haematopoietic stem cells (HSCs) possess unique physiological adaptations to sustain blood cell production and cope with stress responses throughout life.
Hongna Zuo, Aiwei Wu, Mingwei Wang, Liquan Hong, Hu Wang   +4 more
semanticscholar   +1 more source