Results 71 to 80 of about 14,453 (241)

ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells

Acta Pharmaceutica Sinica B
Chemotherapy is currently the mainstay of systemic management for triple-negative breast cancer (TNBC), but chemoresistance significantly impacts patient outcomes.
Yuhua Deng, Zhiyan Chen, Peixian Chen, Yaming Xiong, Chuling Zhang, Qiuyuan Wu, Huiqi Huang, Shuqing Yang, Kun Zhang, Tiancheng He, Wei Li, Guolin Ye, Wei Luo, Hongsheng Wang, Dan Zhou   +14 more
semanticscholar   +1 more source

Association of m1A modification genes polymorphisms with glioma risk in Chinese children Running head: m1A genes polymorphisms and glioma risk

, 2022
Abstract Background Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development.
Fan Liao, Rui-Xi Hua, Xingyu Jia, Yuxiang Liao, Li Yuan, Jichen Ruan, Tianfeng Li, Zhenjian Zhuo, Jing He   +8 more
openaire   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Uncovering renewable energy policy impact channels on land values, the local farm structure, and farmland heterogeneity

American Journal of Agricultural Economics, EarlyView.
Abstract Germany's Renewable Energy Sources Act (REA), enacted in 2000 and subsequently amended, subsidized national renewable energy production with fixed feed‐in tariffs for renewable energy sources (RE) from wind, solar, and biogas. Empirical studies suggest that the policy was creating windfall effects for landowners and attribute farmland use ...
Lars Isenhardt, Stefan Seifert, Saskia Wolff, Tobia Lakes, Marten Graubner, Axel Werwatz, Silke Hüttel   +6 more
wiley   +1 more source

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease

bioRxiv, 2023
One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA modification. Especially the extent of m1A mRNA methylation is highly discussed due to methodological differences. However, one single m1A site in mitochondrial ND5
Marko Jörg, Johanna E Plehn, Marco Kristen, M. Lander, Lukas Walz, Christine Lietz, Julie Wijns, Florian Pichot, Liliana Rojas-Charry, Katja M. Wirtz Martin, N. Ruffini, Nastasja Kreim, Susanne Gerber, Y. Motorin, K. Endres, W. Rossmanith, Axel Methner, Mark Helm, Kristina Friedland   +18 more
semanticscholar   +1 more source

Dinuclear Group 4 Metallocene Catalysts of the Type [(Cp2M)2(μ‐Me)(μ‐C2R)]: Structure‐Activity Relationships in Ethylene Polymerization

Chemistry – A European Journal, EarlyView.
Homo‐ and heterodinuclear group 4 metallocene complexes of the type [(Cp2M)2(μ‐Me)(μ‐C2R)] (M = Ti, Zr) are active catalysts for the polymerization of ethylene in the presence of aluminium‐free activators. The catalytically active species are proposed to have dinuclear character and depending on the type of activator, unique reactivity was observed ...
Hanan Al Hamwi, Mirko Rippke, Anke Spannenberg, Michal Horáček, Jiří Pinkas, Vojtěch Varga, Martin Lamač, Fabian Reiß, Torsten Beweries   +8 more
wiley   +1 more source

DataSheet1_The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma.zip [PDF]

, 2021
Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer.
Ruijie Ming (5483864), Hongjun Xiao (4597642), Jiahui Wei (8289561), Peiyu Du (11770841), Yang Li (7082), Peng Zhou (116747), Enhao Wang (9100260), Shimin Zong (4597636)   +7 more
core   +1 more source

Effect of m1A regulators on prognosis of colorectal cancer

, 2023
Abstract Background Colorectal cancer (CRC) is one of the most serious public health problems. N1-methyladenosine modification appears to play a significant role in colorectal cancer development. Herein, we attempted to develop a prognostic prediction model to predict colorectal cancer prognosis using multiple m1A regulators and clinical ...
Yuqing Jin, Pu Liu, Jiayi Liu, Yu Wang, Weiyan Ren, Xuejiao Tang, Xinrui Shi, Dongchen Pan, Guo Tian, Lei Yang   +9 more
openaire   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

BMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li, Xiaoyu Li, Xunjie Ma, Wei Xiao, Jingjing Zhang   +4 more
doaj   +1 more source