Results 71 to 80 of about 26,465 (226)

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma

BMC Cancer
Background N1-methyladenosine (m1A), among the most common internal modifications on RNAs, has a crucial role to play in cancer development. The purpose of this study were systematically investigate the modification characteristics of m1A in ...
Yingmin Wu, Lian Li, Long Wang, Shenjie Zhang, Zhirui zeng, Jieyu Lu, Zhi Wang, Yewei Zhang, Shilong Zhang, Haiyang Li, Tengxiang Chen   +10 more
doaj   +1 more source

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Nature Communications, 2022
RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su, Ida Monshaugen, Briana Wilson, Fengbin Wang, Arne Klungland, Rune Ougland, Anindya Dutta   +6 more
doaj   +1 more source

Establishment of a new molecular subtyping and prognostic signature with m6A/m5C/m1A/m7G regulatory genes for hepatocellular carcinoma

Heliyon, 2023
Background: RNA modification, including m6A, m5C, m1A, and m7G, participated in tumor progress. Therefore, the purpose of the present study was to explore the role of m6A/m5C/m1A/m7G regulatory genes in the prognosis and tumor microenvironment (TME) for ...
Ting Liu, Yang Wang, Zhizhao Li, Lei Sun, Kun Yang, Jiamin Chen, Xiaoyi Han, Liming Qi, Xingang Zhou, Peng Wang   +9 more
doaj   +1 more source

Research progress of N1-methyladenosine RNA modification in cancer

Cell Communication and Signaling
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu, Shujun Zhang, Xiaohui Gao, Yi Ru, Xinyu Gu, Xinjun Hu   +5 more
doaj   +1 more source

N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Nature Communications, 2021
Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases ...
Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, Dan Dominissini, Lei He, Yong Tian, Chengqi Yi, Zusen Fan   +12 more
doaj   +1 more source

m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling

International Journal of Oral Science
N 1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown.
Shujin Li, Tian Feng, Yuantong Liu, Qichao Yang, An Song, Shuo Wang, Jun Xie, Junjie Zhang, Bifeng Yuan, Zhijun Sun   +9 more
doaj   +1 more source

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia

Biomolecules & Biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
doaj   +1 more source

T-Duality in the Green-Schwarz Formalism, and the Massless/Massive IIA Duality Map [PDF]

, 1999
We derive a component-field expansion of the Green-Schwarz action for the type IIA string, in an arbitrary background of massless NS-NS and R-R bosonic fields, up to quadratic order in the fermionic coordinates \theta.
Achucarro, Alvarez, Bergshoeff, Bergshoeff, Bergshoeff, Brink, Buscher, C.N. Pope, Cowdall, Cremmer, Cremmer, de Wit, Duff, Giveon, Giveon, Grisaru, Grisaru, H. Lü, Hull, K.S. Stelle, Lavrinenko, Lavrinenko, M. Cvetič, Meessen, Romans, Tseytlin   +25 more
core   +4 more sources

ALKBH1‐mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression

Molecular Oncology, 2023
Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen, Hao Wang, Shuyi Mi, Liming Shao, Zhipeng Xu, Meng Xue   +5 more
doaj   +1 more source