Results 91 to 100 of about 26,465 (226)

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Monetary Policy in Chile: A Black Box? [PDF]

This paper studies monetary policy in Chile during the 1986-1997 period. We concentrate in understanding the monetary transmission mechanism by which the Central Bank instrument—the real interest rate—affects total expenditure, output and the inflation ...
Klaus Schmidt-Hebbel, Klaus Schmidt-Hebbel (Series Editor), Luis Felipe Lagos, Norman Loayza, Norman Loayza (Series Editor), Ángel Cabrera   +5 more
core   +3 more sources

Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus [PDF]

, 2016
Background: Evolutionary studies of genes that mediate recognition between sperm and egg contribute to our understanding of reproductive isolation and speciation. Surface receptors involved in fertilization are targets of sexual selection, reinforcement,
De Clerck, Olivier, Lipinska, Agnieszka, Van Damme, Els   +2 more
core   +6 more sources

MRI for Lung Cancer Management: Any Closer to Clinical Application?

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Management of lung cancer (LC) encompasses screening, diagnosis, staging, radiotherapy planning and guidance, therapy monitoring and surveillance. Across these domains, magnetic resonance imaging (MRI) offers a range of morphological and functional imaging capabilities—including diffusion‐weighted imaging (DWI), dynamic contrast‐enhanced (DCE)
Juergen Biederer, Liisa L. Bergmann, Jeanne B. Ackman, Bruno Hochhegger, Lea Azour, Simon M. F. Triphan, Julien Dinkel, Yoshiharu Ohno, Yoshiyuki Ozawa, Edwin J. R. van Beek, Lena Wucherpfennig   +10 more
wiley   +1 more source

Effect of m1A regulators on prognosis of colorectal cancer

, 2023
Abstract Background Colorectal cancer (CRC) is one of the most serious public health problems. N1-methyladenosine modification appears to play a significant role in colorectal cancer development. Herein, we attempted to develop a prognostic prediction model to predict colorectal cancer prognosis using multiple m1A regulators and clinical ...
Yuqing Jin, Pu Liu, Jiayi Liu, Yu Wang, Weiyan Ren, Xuejiao Tang, Xinrui Shi, Dongchen Pan, Guo Tian, Lei Yang   +9 more
openaire   +1 more source

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +1 more source

Transcriptome-wide 1-methyladenosine functional profiling of messenger RNA and long non-coding RNA in bladder cancer

Frontiers in Genetics
Introduction: Post-transcriptional RNA modifications are crucial regulators of tumor development and progression. In many biological processes, N1-methyladenosine (m1A) plays a key role.
Jian-jian Yin, Yan-liang Song, Yu-feng Guo, Yuan-heng Dai, Qi Chang, Tao Wang, Guo-qiang Sun, Ping Lu, Dong-kui Song, Li-rong Zhang, Li-rong Zhang   +10 more
doaj   +1 more source

Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma

The Laryngoscope, EarlyView.
Conflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
Adrian L. James
wiley   +1 more source

Clinical Application of the SAMEO‐ATO Classification and Analysis of the Correlation Between Individual Subgroups and Surgery Duration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Tympanomastoid surgery, encompassing intricate middle ear and mastoid procedures, necessitates a standardized classification system to ensure consistent documentation, enhance comparability, and improve outcome analysis across different clinical settings.
Julia van de Loo, Naledi Jankowski, Marcel Mayer, Hans Eckel, Louis Jansen, Helen Abing, Anne Nobis, Johannsen Jannik, Jens Peter Klußmann, Jan Christoffer Lüers   +9 more
wiley   +1 more source