Results 101 to 110 of about 14,453 (241)
The m1A-SFRP2-NFAT/TOX axis governs T cell exhaustion in gastric cancer
Cellular OncologyWhile immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, their efficacy in gastric cancer (GC) remains limited, underscoring the need for mechanistic biomarkers of immune evasion. We analyzed m1A RNA modification patterns in the TCGA-
Yifan Liu +9 more
semanticscholar +1 more source
Neuroimaging and neurophysiology in infantile‐onset epilepsy after neonatal stroke
Developmental Medicine &Child Neurology, EarlyView.This population‐based retrospective cohort study of 55 newborn infants demonstrated that neonatal MRI and neonatal neurophysiology (amplitude‐integrated EEG, conventional EEG, and somatosensory evoked potentials) combined with follow‐up EEGs during the first year of life provide practical tools for identifying infants at the highest risk of developing ...
Sinikka La Grassa +6 more
wiley +1 more source
Nature Communications, 2022 RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su +6 more
doaj +1 more source
Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley +1 more source
Research advances of mRNA methylation in kidney diseases
Linchuang shenzangbing zazhiRecently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj +1 more source
Nature Communications, 2021 Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases ...
Yanying Wang +12 more
doaj +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Vibrio harveyi is an important bacterial pathogen in marine aquaculture, responsible for outbreaks affecting a wide range of fish species. Early detection of potentially virulent isolates in fish and environmental samples is essential for effective disease prevention and management, particularly under field conditions where the pathogen may be
Javier Barriga‐Cuartero +4 more
wiley +1 more source
Molecular Oncology, 2023 Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen +5 more
doaj +1 more source
Chemical manipulation of m1A mediates its detection in human tRNA
RNA: A publication of the RNA SocietyN1-methyl adenosine (m1A) is a widespread RNA modification present in tRNA, rRNA, and mRNA. m1A modification sites in tRNAs are evolutionarily conserved and its formation on tRNA is catalyzed by methyltransferase TRMT61A and TRMT6 complex.
Kinga Pajdzik +6 more
semanticscholar +1 more source
Harnessing Star Power: The Distinct Effects of Star Inventors on Radical and Incremental Innovation
Journal of Management Studies, EarlyView.Abstract Star inventors are highly valuable resources, offering scarce knowledge and expertise that significantly enhance a firm's innovation performance. Beyond their expertise, what sets star inventors apart is their star status – a role that prescribes them high positions in organizational hierarchy and the power to steer resource allocation within ...
Murod Aliyev, Hyungseok David Yoon
wiley +1 more source