Results 121 to 130 of about 26,465 (226)

m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD

Molecular Neurobiology
AbstractMajor depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by severe impairments in cognitive and functional capacities. This research was conducted to identify RNA modification-related gene signatures and associated functional pathways in MDD. Differentially expressed RNA modification-related genes in MDD were first
Xin Ren, Zhuxiao Feng, Xiaodong Ma, Lijuan Huo, Huiying Zhou, Ayu Bai, Shujie Feng, Ying Zhou, Xuchu Weng, Changhe Fan   +9 more
openaire   +2 more sources

Global Business Cycles and Credit Risk [PDF]

The potential for portfolio diversification is driven broadly by two characteristics: the degree to which systematic risk factors are correlated with each other and the degree of dependence individual firms have to the different types of risk factors ...
Björn-Jakob Treutler, M. Hashem Pesaran, Til Schuermann   +2 more
core  

Fianlimab, a human lymphocyte activation gene‐3 monoclonal antibody, in combination with cemiplimab: Tumor‐specific expansion cohorts in advanced malignancies

Cancer, Volume 132, Issue 9, 1 May 2026.
Abstract Background The dose escalation phase of a first‐in‐human (FIH) study demonstrated acceptable safety and preliminary antitumor activity of fianlimab (anti‐lymphocyte activation gene‐3 [LAG‐3]) as monotherapy and in combination with cemiplimab (anti‐programmed cell death‐1 [PD‐1]). Here, the authors present safety and clinical activity data from
Tae Min Kim, Stephen K. Williamson, Kyriakos P. Papadopoulos, Omid Hamid, Grace K. Dy, Ray McDermott, Ariel Birnbaum, John M. Kaczmar, Nehal Lakhani, Danny Rischin, Debashis Sarker, Afshin Dowlati, Xin‐Hua Zhu, Jyoti Malhotra, Jean‐Francois Pouliot, Jayakumar Mani, Laura Brennan, Fang Fang, Shuquan Chen, Mark Salvati, Israel Lowy, Ahmed Khaled, Karl D. Lewis, Glenn Kroog, Matthew G. Fury, Byoung Chul Cho   +25 more
wiley   +1 more source

Loop Corrections and Naturalness in a Chiral Effective Field Theory

, 2007
The loop expansion is applied to a chiral effective hadronic lagrangian; with the techniques of Infrared Regularization, it is possible to separate out the short-range contributions and to write them as local products of fields that are already present ...
Almbladh, Becher, Becher, Brian D. Serot, Chin, Coleman, Coleman, Dirac, Djukanovic, Dreizler, Ellis, Friar, Friar, Fuchs, Furnstahl, Furnstahl, Furnstahl, Furnstahl, Furnstahl, Furnstahl, Furntahl, Georgi, Hohenberg, Hu, Huertas, Huertas, Huertas, Huertas, Iliopoulos, Itzykson, Jeff McIntire, Kohn, Kohn, Manohar, McIntire, McIntire, McIntire, McIntire, Scherer, Scherer, Schindler, Schindler, Schmid, Serot, Serot, Serot, Serot, Speicher, Tang, Walecka, Walecka, Wehrberger, Ying Hu   +52 more
core   +1 more source

Chloroplast Phylogenomics and Barcode Discovery in Medicinal Stachys Species Reveal Evolutionary Relationships and Adaptive Signatures

Ecology and Evolution, Volume 16, Issue 5, May 2026.
This study presents the first complete chloroplast genomes of two medicinally important Stachys species, S. persica and S. germanica. Comparative phylogenomic analyses revealed highly conserved genomes with lineage‐specific variations, identified hypervariable regions as candidate DNA barcodes, and detected signatures of positive selection in the petB ...
Fatemeh Sadat Ghotbi, Aboozar Soorni
wiley   +1 more source

Dynamical Systems Gradient method for solving nonlinear equations with monotone operators

, 2008
A version of the Dynamical Systems Gradient Method for solving ill-posed nonlinear monotone operator equations is studied in this paper. A discrepancy principle is proposed and justified. A numerical experiment was carried out with the new stopping rule.
A. G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, D. Pascali, E. Zeidler, I.V. Skrypnik, J.L. Lions, K. Deimling, M.M. Vainberg, N. S. Hoang, N.S. Hoang, U. Tautenhahn, U. Tautenhahn, V. Ivanov, V.A. Morozov   +24 more
core   +2 more sources

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Nominal stylized facts of U. S. business cycles [PDF]

The authors investigate the basic nominal stylized facts of business cycles in the United States, using monthly data from 1960:1 to 1993:4 and the methodology suggested by Kydland and Prescott (1990).
Apostolos Serletis, David Krause
core   +1 more source

Large mammal recovery in the wake of human population decline

Journal of Applied Ecology, Volume 63, Issue 5, May 2026.
Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen, Benjamin R. Goldstein, Keita Fukasawa, Fabiola Iannarilli, Roland Kays   +4 more
wiley   +1 more source