Results 141 to 150 of about 11,313 (179)

Regulation of RNA methylation linked to drug resistance in gastric cancer. [PDF]

Front Cell Dev Biol
Yang Z, Ma Y, Xu Z, Liu H, Gu X, Sun J.
europepmc   +1 more source

Triple-Negative Breast Cancer Cells Resist Natural Killer Cell-Mediated Killing Through Interleukin-11 Trans-Signaling. [PDF]

Adv Sci (Weinh)
Yang H, Jia H, Wu R, Tong H, Chen L, Luo KQ.   +5 more
europepmc   +1 more source

Integrated primary tumor and all metastatic lymph nodes radiomics from 18 F-FDG PET/CT for precise M1 subclassification in nasopharyngeal carcinoma. [PDF]

BMC Cancer
Zhang Y, Xu S, Hu Y.
europepmc   +1 more source

Hidden in plain sight: illuminating the tRNA landscape by sequencing. [PDF]

Genome Biol
Marlow K, Su Z.
europepmc   +1 more source

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Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke

Translational Stroke Research, 2022
Methylation of adenosine at N1 position yields N1-methyladenosine (m1A), which is an epitranscriptomic modification that regulates mRNA metabolism. Recent studies showed that altered m1A methylation promotes acute and chronic neurological diseases. We currently evaluated the effect of focal ischemia on cerebral m1A methylome and its machinery.
Anil Kiran Chokkalla, Raghu Vemuganti, Qing Dai   +2 more
exaly   +3 more sources

m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation

Cell Reports, 2022
N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Yoon Ki Kim, Hongseok Ha
exaly   +3 more sources

Effect of M1a and M1b Category in Metastatic Colorectal Cancer [PDF]

Oncologist, 2014
Abstract Background. In 2009, the American Joint Committee on Cancer version 7 staging system introduced the M1 subclassifications M1a (single metastatic site) and M1b (peritoneal or multiple metastatic sites). The study objectives were to evaluate the prognostic effect of site of metastasis and M1a/b
Hagen Kennecke, Winson Cheung, Charles Blanke   +2 more
exaly   +3 more sources

N 1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]

Journal of Biochemistry, 2020
AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi, Igarashi Kazuhiko, Shima Hiroki   +2 more
exaly   +3 more sources

Mo’ m1A, mo’ problems

Cell Chemical Biology
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
openaire   +2 more sources