Results 141 to 150 of about 14,453 (241)

m1A-mediated regulation of BIRC2 mRNA stability drives apoptosis evasion and tumor progression in liver cancer

Cell Death and Disease
Liver cancer remains one of the leading causes of cancer-related mortality worldwide, with its progression driven by uncontrolled cell proliferation and evasion of apoptosis.
Yingmin Wu, Shenjie Zhang, Shilong Zhang, Jieyu Lu, Yuntao Yang, Zhirui Zeng, Shan Lei, Rui Mi, Yewei Zhang, Lichen Ge, Tengxiang Chen, Haiyang Li   +11 more
doaj   +1 more source

Identification of the m6A/m5C/m1A methylation modification genes in Alzheimer’s disease based on bioinformatic analysis

Aging
Background: As a progressive neurodegenerative disease, the comprehensive understanding of the pathogenesis of Alzheimer’s disease (AD) is yet to be clarified. Modifications in RNA, including m6A/m5C/m1A, affect the onset and progression of many diseases.
Qifa Tan, Desheng Zhou, Yuan Guo, Haijun Chen, Peng Xie   +4 more
semanticscholar   +1 more source

Peer review of the pesticide risk assessment of the active substance flurochloridone

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Austria and co‐rapporteur Member State Croatia for the pesticide active substance flurochloridone are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Amarela Becirovic, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +46 more
wiley   +1 more source

A prognostic signature based on genes associated with m6A/m5C/m1A/m7G modifications and its immunological characteristics in clear cell renal cell carcinoma

Scientific Reports
Clear cell renal cell carcinoma (ccRCC) is characterized by a high incidence and mortality rate. Despite advancements in therapeutic interventions, the prognosis for renal cancer patients remains suboptimal.
Wei He, Zixiang Cong, Chengtao Niu, F. Cheng, Tinghai Yi, Zhongshun Yao, Yiming Zhang, Xue Jiang, Xintong Sun, Z. Niu, Qiang Fu   +10 more
semanticscholar   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

Quantification of tRNA m1A modification by templated-ligation qPCR

RNA: A publication of the RNA Society
N1-methyladenosine (m1A) is a widespread modification in all eukaryotic, many archaeal, and some bacterial tRNAs. m1A is generally located in the T loop of cytosolic tRNA and between the acceptor and D stems of mitochondrial tRNAs; it is involved in the ...
Wen Zhang, Hankui Chen, Marek Sobczyk, Daniel Krochmal, Christopher D Katanski, Mahdi Assari, Amy Chen, Yichen Hou, Qing Dai, Tao Pan   +9 more
semanticscholar   +1 more source

m1A-Ensem: accurate identification of 1-methyladenosine sites through ensemble models

BioData Mining
Background 1-methyladenosine (m1A) is a variant of methyladenosine that holds a methyl substituent in the 1st position having a prominent role in RNA stability and human metabolites.
Muhammad Taseer Suleman, Fahad Alturise, Tamim Alkhalifah, Y. Khan   +3 more
semanticscholar   +1 more source

m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma

Experimental and Therapeutic Medicine
N1-methyladenosine (m1A), a methylation of RNA, is gaining attention for its role in diverse biological processes. However, the potential roles of m1A regulatory-mediated methylation modifications in multiple myeloma (MM) remain unclear.
Jiaqi Fu, Xingjun Han, Wei Gao, Manya Yu, X. Cui   +4 more
semanticscholar   +1 more source

A novel m6A/m5C/m1A/m7G-related classification and risk signature predicts prognosis and reveals immunotherapy inclination in gastric cancer

Translational Cancer Research
Background Gastric cancer (GC) is characterized by high morbidity and mortality rates, and the prognosis is not optimistic. Therefore, the search for new biomarkers is crucial. Methylation modifications in RNA modifications play a crucial role in tumors.
Ruyue Chen, Lixin Jiang
semanticscholar   +1 more source

Association of genetic variants in m1A modification core genes and neuroblastoma risk [PDF]

Neuroblastoma tightly linked with genetic abnormality. The core genes responsible for RNA N1-methyladenosine (m1A) modification are critical in tumor development. Nevertheless, few reports revealed the function of m1A modification core gene polymorphisms
Xinxin Zhang, Zhonghua Yang, Susu Jiang, Lei Lin, Jiao Zhang, Siqi Dong, Wenli Zhang, Jiwen Cheng, Zhenjian Zhuo, Haixia Zhou, Jing He, Suhong Li, Jinhong Zhu, Liping Chen, Wenhan Yang, Yong Li, Li Li   +16 more
core   +1 more source