Results 31 to 40 of about 11,313 (179)
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the impact of lymph node metastasis on the survival of SCLC patients with M1a disease. Methods We retrospectively analyzed the medical records of 7027 SCLC patients with M1a disease from 2004 to 2015 in SEER database.
YANG Hao, MEI Tonghua
doaj +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-β Pathology. [PDF]
Adv Sci (Weinh)ABSTRACT Amyloid‐beta (Aβ) aggregation, mitochondrial dysfunction, and cognitive decline are hallmarks of Alzheimer's disease (AD), but its initiating molecular events remain unknown. Given that RNA modifications regulate neurodevelopment and neurodegeneration, we explore their functional role in 5xFAD mice, an Aβ
Li Y +25 more
europepmc +3 more sources
Frontiers in Genetics, 2022 Background: Gliomas are the most common and fatal malignant type of tumor of the central nervous system. RNA post-transcriptional modifications, as a frontier and hotspot in the field of epigenetics, have attracted increased attention in recent years ...
Dongqi Shao +6 more
doaj +1 more source
Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer’s disease
Human Molecular Genetics, 2021 AbstractRNA modifications affect many aspects of RNA metabolism and are involved in the regulation of many different biological processes. Mono-methylation of adenosine in the N1 position, N1-methyladensoine (m1A), is a reversible modification that is known to target rRNAs and tRNAs.
Andrew M Shafik +4 more
openaire +2 more sources
, 2022 Abstract Background Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development.
Fan Liao +8 more
openaire +1 more source
m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer
Translational Oncology, 2019 BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao +17 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer.
Enhao Wang +7 more
doaj +1 more source
Frontiers in Immunology, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Meng Mao +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Multidisciplinary Treatment for Esophagogastric Junction Cancer From a Dutch Perspective
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Esophagogastric junction (EGJ) cancer is an increasing health burden worldwide. Over the past decade, significant advancements in centralization, multimodal treatment strategies, as well as the widespread adoption of minimally invasive surgical techniques, have led to marked improvements in perioperative outcomes and overall survival of EGJ ...
Hidde C. G. Overtoom +1 more
wiley +1 more source