Results 31 to 40 of about 26,465 (226)
N1-methyladenosine modification in cancer biology: Current status and future perspectives
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li +2 more
doaj +1 more source
The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
doaj +1 more source
M1a/M1b esophageal carcinoma: Clinical relevance [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1999 The 1997 staging system for esophageal carcinoma subdivides distant metastatic disease (M1) into M1a (nonregional lymph node metastases) and M1b (other metastases). This study evaluates the relevance of this classification.One hundred forty patients were identified with M1 disease, 36 (26%) M1a and 104 (74%) M1b.
Christie, Neil A. +7 more
openaire +2 more sources
Frontiers in Immunology, 2021 Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis.
Jinhui Liu +6 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators.
Jia-Hui Yao +6 more
doaj +1 more source
Genetic characteristics and prognostic implications of m1A regulators in pancreatic cancer [PDF]
Bioscience Reports, 2021 Abstract Studies have identified the methylation of N1 adenosine (m1A), an RNA modification, playing an important role in the progression of the tumorigenesis. The present study aimed to analyze the genetic characteristics and prognostic value of m1A regulators in pancreatic cancer.
Qingyuan Zheng +4 more
openaire +2 more sources
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
doaj +1 more source
Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]
E3S Web of Conferences, 2020 N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
doaj +1 more source
Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer’s disease
Human Molecular Genetics, 2021 AbstractRNA modifications affect many aspects of RNA metabolism and are involved in the regulation of many different biological processes. Mono-methylation of adenosine in the N1 position, N1-methyladensoine (m1A), is a reversible modification that is known to target rRNAs and tRNAs.
Andrew M Shafik +4 more
openaire +2 more sources
N 1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]
The Journal of Biochemistry, 2020 AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi, Hiroki Shima
openaire +2 more sources