m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +2 more
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OncoImmunology, 2021 Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yuzhen Gao, Xinyou Xie, Liangjing Wang
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TRMT6-directed m1A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes [PDF]
npj Precision OncologyN1-Methyladenosine (m1A) is a prevalent RNA modification that governs RNA metabolism, structure, stability, and translation. Yet its cancer-wide landscape and functional impact remain largely unexplored.
Weihao Xue +7 more
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Identification and validation of an m1A-score model to predict outcomes and immunomodulation in lung squamous cell carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]
Discover OncologyLung squamous cell carcinoma (LUSC) is a common and aggressive subtype of lung cancer, characterized by difficult treatment and poor prognosis. N1-methyladenosine (m1A) is an RNA modification that plays a crucial role in various biological processes ...
Han Gong +5 more
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Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
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Frontiers in Immunology, 2022 RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC).
Shen Shen, Chen Xue
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THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network [PDF]
Frontiers in Geneticsm1A modification, as a pivotal RNA epigenetic modification, plays a central regulatory role in the pathogenesis and progression of complex human diseases, including cancer.
Hongyan Gao +4 more
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Frontiers in Immunology, 2022 RNA modification of m6A/m5C/m1A contributes to the occurrence and development of cancer. Consequently, this study aimed to investigate the functions of m6A/m5C/m1A regulated genes in the prognosis and immune microenvironment of hepatocellular carcinoma ...
Dan Li +9 more
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RNA m1A Methyltransferase TRMT6 Predicts Poorer Prognosis and Promotes Malignant Behavior in Glioma
Frontiers in Molecular Biosciences, 2021 Background: Glioma is the most prevalent central nervous system tumor in humans, and its prognosis remains unsatisfactory due to a lack of effective therapeutic targets.
Beibei Wang +3 more
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Harnessing m1A modification: a new frontier in cancer immunotherapy
Frontiers in ImmunologyN1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang +10 more
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