Harnessing m1A modification: a new frontier in cancer immunotherapy [PDF]
Frontiers in ImmunologyN1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang +10 more
doaj +6 more sources
m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +2 more
exaly +7 more sources
M1a prostate cancer: Results of a Dutch multidisciplinary consensus meeting [PDF]
BJUI Compass, 2021 Objectives To determine the consensus of a Dutch multidisciplinary expert panel on the diagnostic evaluation and treatment of de novo and recurrent metastatic prostate cancer (PCa) limited to non‐regional lymph nodes (M1a) in daily clinical practice ...
Shafak Aluwini +7 more
doaj +5 more sources
Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation [PDF]
EMBO ReportsDinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li +10 more
doaj +3 more sources
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
Cell & BioscienceBackground N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang +9 more
doaj +4 more sources
The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia [PDF]
Biomolecules & BiomedicineRecent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong +3 more
doaj +4 more sources
Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer
Cancer Reports, 2023 Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunjie Xu, Lei Gu
exaly +4 more sources
M1a/M1b esophageal carcinoma: Clinical relevance [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1999 The 1997 staging system for esophageal carcinoma subdivides distant metastatic disease (M1) into M1a (nonregional lymph node metastases) and M1b (other metastases). This study evaluates the relevance of this classification.One hundred forty patients were identified with M1 disease, 36 (26%) M1a and 104 (74%) M1b.
Christie, Neil A. +7 more
openaire +4 more sources
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA [PDF]
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
doaj +2 more sources
m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration [PDF]
Nature, 2023 TDP-43 binds to N ^1-methyladenosine on CAG repeat RNA, resulting in the formation of gel-like TDP-43 aggregates in the cytoplasm that resemble those observed in neurological disease pathology.
Yuxiang Sun +14 more
semanticscholar +3 more sources