Results 11 to 20 of about 11,313 (179)

M1a prostate cancer: Results of a Dutch multidisciplinary consensus meeting

BJUI Compass, 2021
Objectives To determine the consensus of a Dutch multidisciplinary expert panel on the diagnostic evaluation and treatment of de novo and recurrent metastatic prostate cancer (PCa) limited to non‐regional lymph nodes (M1a) in daily clinical practice ...
Shafak Aluwini, Daniela E. Oprea‐Lager, Hilda deBarros, Niven Mehra, Herman Stoevelaar, Derya Yakar, Henk van derPoel, Dutch M1a Prostate Cancer Working Group   +7 more
doaj   +3 more sources

Harnessing m1A modification: a new frontier in cancer immunotherapy

Frontiers in Immunology
N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang, Xiaoqing Ma, Siyu Chen, Minyan Fan, Chenying Jin, Yushi Chen, Shaodong Wang, Zhiying Wang, Fei Meng, Chengwan Zhang, Lin Yang   +10 more
doaj   +3 more sources

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
doaj   +3 more sources

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +3 more sources

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target [PDF]

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +2 more sources

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

eLife, 2023
Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
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Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Guangyao Bao, Tian Li, Xiaojiao Guan, Yao Yao, Jie Liang, Yifang Xiang, Xinwen Zhong   +6 more
doaj   +1 more source

Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

OncoImmunology, 2021
Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang, Jun Zhang   +9 more
doaj   +1 more source

N1-methyladenosine modification in cancer biology: Current status and future perspectives

Computational and Structural Biotechnology Journal, 2022
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li, Haisheng Zhang, Hongsheng Wang   +2 more
doaj   +1 more source

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source