Results 11 to 20 of about 13,010 (203)

Identification and validation of an m1A-score model to predict outcomes and immunomodulation in lung squamous cell carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]

Discover Oncology
Lung squamous cell carcinoma (LUSC) is a common and aggressive subtype of lung cancer, characterized by difficult treatment and poor prognosis. N1-methyladenosine (m1A) is an RNA modification that plays a crucial role in various biological processes ...
Han Gong, Haihang Zhang, Lin Zhu, Jing Liu, Dehui Xiong, Yibin Zhang   +5 more
doaj   +3 more sources

m¹A and m⁶A RNA Methylations as Druggable Targets in Cancer. [PDF]

Pharmaceuticals (Basel)
Epitranscriptomic modifications, particularly RNA methylations, have emerged as regulators of gene expression, with their dysregulation acting as a key factor in tumorigenesis and metastatic progression. This review evaluates the therapeutic landscapes of N6-methyladenosine (m6A) and N1-methyladenosine (m1A) modifications in cancer.
Gazaloğlu Y, Sağlam-Şen B, Akgül B.
europepmc   +3 more sources

M1a/M1b esophageal carcinoma: Clinical relevance [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1999
The 1997 staging system for esophageal carcinoma subdivides distant metastatic disease (M1) into M1a (nonregional lymph node metastases) and M1b (other metastases). This study evaluates the relevance of this classification.One hundred forty patients were identified with M1 disease, 36 (26%) M1a and 104 (74%) M1b.
Christie, Neil A., Rice, Thomas W., DeCamp, Malcolm M., Goldblum, John R., Adelstein, David J., Zuccaro, Gregory, Rybicki, Lisa A., Blackstone, Eugene H.   +7 more
openaire   +4 more sources

Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA

Genomics, Proteomics & Bioinformatics, 2018
More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
doaj   +2 more sources

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +3 more sources

TRMT6-directed m1A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes [PDF]

npj Precision Oncology
N1-Methyladenosine (m1A) is a prevalent RNA modification that governs RNA metabolism, structure, stability, and translation. Yet its cancer-wide landscape and functional impact remain largely unexplored.
Weihao Xue, Liqiang Zhu, Xiaolong Wei, Jinqi Sun, Weihao Lin, Shaomin Huang, Lianpin Wu, Donghong Zhang   +7 more
doaj   +2 more sources

N1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]

Journal of Biochemistry, 2020
AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi
exaly   +3 more sources

m1A Regulatory gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma

European Journal of Medical Research, 2023
Adenosine N1 methylation (m1A) of RNA, a type of post-transcriptional modification, has been shown to play a significant role in the progression of cancer.
Linjun Zhou, Weidong Zhou, Yuan Li, Ruifang Hua   +3 more
doaj   +2 more sources

m1A-mediated regulation of BIRC2 mRNA stability drives apoptosis evasion and tumor progression in liver cancer [PDF]

Cell Death and Disease
Liver cancer remains one of the leading causes of cancer-related mortality worldwide, with its progression driven by uncontrolled cell proliferation and evasion of apoptosis.
Yingmin Wu, Shenjie Zhang, Shilong Zhang, Jieyu Lu, Yuntao Yang, Zhirui Zeng, Shan Lei, Rui Mi, Yewei Zhang, Lichen Ge, Tengxiang Chen, Haiyang Li   +11 more
doaj   +2 more sources

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
doaj   +3 more sources