Results 21 to 30 of about 250,698 (260)
TLR Ignores Methylated RNA? [PDF]
Immunity, 2005 CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.
Ishii, Ken J., Akira, Shizuo
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Emerging roles of RNA methylation in gastrointestinal cancers
Cancer Cell International, 2020 RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie +8 more
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Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality
Scientific Reports, 2023 This study aims to perform a comprehensive genomic analysis to assess the influence of overexpression of MYO1E in non-small cell lung carcinoma (NSCLC) and whether there are differences in survival and mortality risk in NSCLC patients depending on both ...
Ignacio Jusue-Torres +21 more
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The role of RNA m6A methylation in lipid metabolism
Frontiers in Endocrinology, 2022 The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner.
Yuting Wang +5 more
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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. [PDF]
PLoS Pathogens, 2012 RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome.
Hongping Dong +10 more
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PLOS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences. The RdDM pathway is unique to plants, although other mechanisms of RNA-directed chromatin modification have also been described in fungi and animals.
Robert M. Erdmann, Colette L. Picard
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RNA‐binding proteins and RNA methylation in myeloid cells
Immunological Reviews, 2021 AbstractRNA‐binding proteins (RBPs) regulate all aspects of the life of mRNA transcripts. They are critically important in regulating immune responses, most notably by restraining excessive inflammation that can potentially lead to tissue damage.
Marian Bataclan +2 more
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RNA-directed DNA methylation [PDF]
Current Opinion in Plant Biology, 2011 DNA methylation is an important epigenetic mechanism for silencing transposons and other repetitive elements, and for stable repression of specific transgenes and endogenous genes. Plants can utilize small interfering RNAs (siRNAs) to guide de novo DNA methyltransferases for the establishment of sequence-specific DNA methylation.
Huiming, Zhang, Jian-Kang, Zhu
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Journal of Inflammation Research, 2022 Xin-Yu Li,1,2 Xi-Tao Yang1 1Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Neurosurgery, Shanghai ...
Li XY, Yang XT
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Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration [PDF]
International Journal of OphthalmologyAIM: To investigate the role of RNA methylation in retinal pigment epithelial (RPE) cells in age-related macular degeneration (AMD). METHODS: RNA methylation-related gene expression profiles of AMD patient and normal control retinal pigment epithelium ...
Ya-Jun Gong +4 more
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