Results 21 to 30 of about 248,618 (295)
Computational and Structural Biotechnology Journal, 2023 As an internal modification of transcripts, RNA methylation determines RNA fate by changing RNA–protein binding affinity. In plants, RNA methylation is ubiquitous and is involved in all aspects of RNA post-transcriptional regulation.
Xiaojun Li +13 more
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Deciphering RNA Methylation in Cancer
, 2021 Every single RNA nucleotide may undergo a variety of (post-)transcriptional chemical modifications. Historically, the inefficiency of detection methods and the difficulties in chemical structure elucidation have been a rate-limiting step in the discovery
Jerónimo, Carmen +6 more
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RNA Methylation Clears the Way [PDF]
Developmental Cell, 2017 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.
Cassandra, Kontur, Antonio, Giraldez
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Frontiers in Cell and Developmental Biology, 2021 RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu +24 more
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TGF-β Regulates m6A RNA Methylation after PM2.5 Exposure
, 2023 PM2.5 exposure leads to a variety of respiratory diseases, including pulmonary fibrosis, metastatic lung cancer, etc. Exposure to PM2.5 results in the alteration of epigenetic modification. M6A RNA methylation is an essential epigenetic modification that
Zhigang Li +3 more
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Bibliometric and visual analysis of RAN methylation in cardiovascular disease
Frontiers in Cardiovascular Medicine, 2023 BackgroundRNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD.MethodsArticles and reviews on RNA ...
Boce Song +7 more
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Journal of General Virology, 2014 The 5′ end of eukaryotic mRNA contains the type-1 (m7GpppNm) or type-2 (m7GpppNmNm) cap structure. Many viruses have evolved various mechanisms to develop their own capping enzymes (e.g. flavivirus and coronavirus) or to ‘steal’ caps from host mRNAs (e.g. influenza virus).
Hongping, Dong +5 more
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Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
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MedComm – Future Medicine, 2023 RNA methylation plays a key role across biological processes, which could be utilized as new weapons for cancer management. However, the implication of RNA methylation regulators in cancers, especially in clear cell renal cell cancer (ccRCC), remains ...
Aimin Jiang +12 more
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TLR Ignores Methylated RNA? [PDF]
Immunity, 2005 CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.
Ishii, Ken J., Akira, Shizuo
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