Results 21 to 30 of about 1,130,807 (299)

Dynamic regulation and key roles of ribonucleic acid methylation

Frontiers in Cellular Neuroscience, 2022
Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou, Jia Zou, Hui Liu, Hui Liu, Wei Tan, Yi-qi Chen, Yi-qi Chen, Jing Dong, Jing Dong, Shu-yuan Bai, Shu-yuan Bai, Zhao-xia Wu, Yan Zeng, Yan Zeng, Yan Zeng   +14 more
doaj   +1 more source

Flavivirus RNA methylation

Journal of General Virology, 2014
The 5′ end of eukaryotic mRNA contains the type-1 (m7GpppNm) or type-2 (m7GpppNmNm) cap structure. Many viruses have evolved various mechanisms to develop their own capping enzymes (e.g. flavivirus and coronavirus) or to ‘steal’ caps from host mRNAs (e.g. influenza virus).
Hongping, Dong, Katja, Fink, Roland, Züst, Siew Pheng, Lim, Cheng-Feng, Qin, Pei-Yong, Shi   +5 more
openaire   +2 more sources

Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]

, 2009
In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
core   +1 more source

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M., Basel Khraiwesh, Khraiwesh, Basel, Muhammad Arif, Khraiwesh, B., Arif, Muhammad Asif, Frank, W., Frank, Wolfgang, Wolfgang Frank   +8 more
core   +2 more sources

Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality

Scientific Reports, 2023
This study aims to perform a comprehensive genomic analysis to assess the influence of overexpression of MYO1E in non-small cell lung carcinoma (NSCLC) and whether there are differences in survival and mortality risk in NSCLC patients depending on both ...
Ignacio Jusue-Torres, Richies Tiv, Julio C. Ricarte-Filho, Apurva Mallisetty, Leglys Contreras-Vargas, Maria Jose Godoy-Calderon, Karam Khaddour, Kathleen Kennedy, Klara Valyi-Nagy, Odile David, Martha Menchaca, Anastasia Kottorou, Angelos Koutras, Foteinos Dimitrakopoulos, Khaled M. Abdelhady, Malek Massad, Israel Rubinstein, Lawrence Feldman, John Stewart, Takeshi Shimamura, Ludmila Danilova, Alicia Hulbert   +21 more
doaj   +1 more source

Emerging roles of RNA methylation in gastrointestinal cancers

Cancer Cell International, 2020
RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou, Xiaoyi Yan   +8 more
doaj   +1 more source

Extensive lysine methylation in hyperthermophilic crenarchaea : potential implications for protein stability and recombinant enzymes [PDF]

, 2010
In eukarya and bacteria, lysine methylation is relatively rare and is catalysed by sequence-specific lysine methyltransferases that typically have only a single-protein target.
Botting, Catherine H., White, Malcolm F., Talbot, Paul, Malcolm F. White, Paytubi, Sonia, Paul Talbot, Catherine H. Botting, Sonia Paytubi   +7 more
core   +1 more source

The role of RNA m6A methylation in lipid metabolism

Frontiers in Endocrinology, 2022
The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner.
Yuting Wang, Yujie Wang, Jiarui Gu, Tianhong Su, Xiaosong Gu, Yu Feng   +5 more
doaj   +1 more source

TLR Ignores Methylated RNA? [PDF]

Immunity, 2005
CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.
Ishii, Ken J., Akira, Shizuo
openaire   +2 more sources

RNA‐binding proteins and RNA methylation in myeloid cells

Immunological Reviews, 2021
AbstractRNA‐binding proteins (RBPs) regulate all aspects of the life of mRNA transcripts. They are critically important in regulating immune responses, most notably by restraining excessive inflammation that can potentially lead to tissue damage.
Marian Bataclan, Cristina Leoni, Silvia Monticelli   +2 more
openaire   +3 more sources