Results 101 to 110 of about 4,508 (221)

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

Plant ribosomes as a score to fathom the melody of 2’-O-methylation across evolution

RNA Biology
2’-O-ribose methylation (2’-O-Me) is one of the most common RNA modifications detected in ribosomal RNAs (rRNA) from bacteria to eukaryotic cells. 2’-O-Me favours a specific RNA conformation and protects RNA from hydrolysis.
Sara Alina Neumann, Christine Gaspin, Julio Sáez-Vásquez   +2 more
doaj   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

Epitranscriptomics: Mapping Methods and Beyond [PDF]

BioTechniques, 2018
The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
openaire   +2 more sources

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

Frontiers in Immunology
BackgroundEpitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases.
Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen   +28 more
doaj   +1 more source

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells, 2019
Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast, Paul H.A. Quax, A. Yaël Nossent   +2 more
doaj   +1 more source

Comprehensive Genome‐Wide Identification and Expression Analysis of the N6‐Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Exogenous melatonin has emerged as a pivotal multifunctional signaling molecule, recognized for its critical role in enhancing stress tolerance and improving crop productivity. N6‐methyladenosine (m6A) is the most prevalent internal modification found in eukaryotic mRNA and plays a crucial role in regulating plant growth, development, and ...
Hira Khanzada, Ghulam Mustafa Wassan, Ping Wang, Saba Khanzada, Xiaoning Wang, Zhihui Xia   +5 more
wiley   +1 more source

Clinical Perspectives in Epitranscriptomics

Current Opinion in Genetics & Development
Epitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation. Increasing knowledge about epitranscriptomic landscapes implicated in disease pathogenesis proves an invaluable opportunity for the identification of epitranscriptomic biomarkers ...
Eloy Santos-Pujol, Carlos Quero-Dotor, Manel Esteller   +2 more
openaire   +2 more sources

The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin? [PDF]

, 2019
Translation of mRNA is a highly regulated process that is tightly coordinated with cotranslational protein maturation. Recently, mRNA modifications and tRNA modifications - the so called epitranscriptome - have added a new layer of regulation that is ...
Leidel, Sebastian A., Ranjan, Namit
core   +2 more sources