Results 121 to 130 of about 3,547 (209)

Reading the epitranscriptome of the human malaria parasite

Epigenetic machinery has emerged as a central player in gene regulation and chromatin organization in Plasmodium spp. Epigenetic modifications on histones and their role in antigenic variation in P. falciparum are widely studied.
Arumugam Rajavelu, Gayathri Govindaraju
core   +1 more source

Studying m6A in the brain: a perspective on current methods, challenges, and future directions

Frontiers in Molecular Neuroscience
A major mechanism of post-transcriptional RNA regulation in cells is the addition of chemical modifications to RNA nucleosides, which contributes to nearly every aspect of the RNA life cycle. N6-methyladenosine (m6A) is a highly prevalent modification in
Matthew Tegowski, Kate D. Meyer, Kate D. Meyer   +2 more
doaj   +1 more source

Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

eLife
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the forces underlying
David Dierks, Ran Shachar, Ronit Nir, Miguel Angel Garcia-Campos, Anna Uzonyi, David Wiener, Ursula Toth, Walter Rossmanith, Lior Lasman, Boris Slobodin, Jacob H Hanna, Yaron Antebi, Ruth Scherz-Shouval, Schraga Schwartz   +13 more
doaj   +1 more source

Development of sequencing methods to illuminate the epitranscriptome

RNA modifications are chemical marks which expand genetic vocabulary beyond the canonical A, G, C, and T/U. The first RNA modification was discovered in 1957.
Heng, Joel Jia Wei
core   +1 more source

The extensive m5C epitranscriptome of Thermococcus kodakarensis is generated by a suite of RNA methyltransferases that support thermophily

RNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (m5C) is abundant across diverse RNAs and fitness-relevant across ...
Ryan T. Fuchs, Brett W. Burkhart, G. Brett Robb, Hallie P. Febvre, Victoria Talbott, Nan Dai, Kristin A. Fluke, Thomas J. Santangelo, Ivan R. Corrêa, Jackson Schiltz, Eric J. Wolf, Yueh-Lin Tsai, Liam Elkins   +12 more
core   +1 more source

Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells. [PDF]

Stem Cell Reports
Zhang K, Liang H, Chen S.
europepmc   +1 more source

A nanopore-based HIV-1 reference epitranscriptome. [PDF]

Nucleic Acids Res
Bosmeny MS, Pater AA, Zhang L, Larkai LL, Sha BE, Lyu Z, Damha MJ, Mamede JI, Gagnon KT.   +8 more
europepmc   +1 more source

Epitranscriptome regulation [PDF]

Nature Structural & Molecular Biology, 2018
Dominissini, Dan, Rechavi, Gideon
openaire   +1 more source

Poxvirus infection triggers remodeling of host m⁶A epitranscriptome and benefits from the m⁶A regulatory responses. [PDF]

Virol J
Kwon T, Morales DP, Mikolitis AS, Mach PM, Gleasner CD, Micheva-Viteva SN.   +5 more
europepmc   +1 more source

Editorial: Protein-RNA interplay-regulated signaling in stem cells and cancer

Frontiers in Cell and Developmental Biology, 2023
Xichen Bao, Xiaoxing Li, William K. K. Wu, Yanquan Zhang, Liang Zhou   +4 more
doaj   +1 more source