Results 51 to 60 of about 4,508 (221)

Infection Meets Inflammation: N6-Methyladenosine, an Internal Messenger RNA Modification as a Tool for Pharmacological Regulation of Host–Pathogen Interactions

Biomolecules, 2023
The significance of internal mRNA modifications for the modulation of transcript stability, for regulation of nuclear export and translation efficiency, and their role in suppressing innate immunity is well documented.
Milena N. Leseva, Brigitta Buttari, Luciano Saso, Petya A. Dimitrova   +3 more
doaj   +1 more source

Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]

, 2015
Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan, Bodi, Zsuzsanna, Bottley, Andrew, Fray, Rupert G., May, Sean, May, Sean T.   +5 more
core   +3 more sources

Interpretable deep cross networks unveiled common signatures of dysregulated epitranscriptomes across 12 cancer types

Molecular Therapy: Nucleic Acids
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song   +10 more
doaj   +1 more source

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]

, 2018
The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke, Chen, Fangyi, Drennan, Catherine L., Essigmann, John M, Humulock, Zachary T., Jost, Marco, Li, Deyu, Tang, Qi, Yang, Xuedong   +8 more
core   +1 more source

Charting the unknown epitranscriptome

Nature Reviews Molecular Cell Biology, 2017
RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the ...
Novoa Pardo, EM, Mason, CE, Mattick, JS
openaire   +3 more sources

Epitranscriptomic investigation of myopia-associated RNA editing in the retina

Frontiers in Neuroscience, 2023
Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan, Xu-Bin Pan, Xu-Bin Pan, Xu-Bin Pan, Yu-Shan He, Yu-Shan He, Yu-Shan He, Zijing Lu, Zijing Lu, Zijing Lu, Zijing Lu, Hao-Ran Pan, Hao-Ran Pan, Hao-Ran Pan, Hao-Ran Pan, Zhi-Yuan Wei, Zhi-Yuan Wei, Zhi-Yuan Wei, Yun-Yun Jin, Yun-Yun Jin, Yun-Yun Jin, Jihong Wang, Jian-Huan Chen, Jian-Huan Chen, Jian-Huan Chen   +24 more
doaj   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar, Eisenberg, Eli, Kaniewska, Paulina, Levanon, Erez, Levy, Oren, Porath, Hagit T., Rosenthal, Joshua J. C., Schaffer, Amos A.   +7 more
core   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data [PDF]

, 2013
A large number of computational methods have been developed for analyzing differential gene expression in RNA-seq data. We describe a comprehensive evaluation of common methods using the SEQC benchmark dataset and ENCODE data. We consider a number of key
Azra Krek, Christopher E Mason, Doron Betel, Franck Rapaport, Mono Pirun, Nicholas D Socci, Paul Zumbo, Raya Khanin, Yupu Liang   +8 more
core   +1 more source