Results 51 to 60 of about 3,547 (209)

M6A-Atlas: A comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome

, 2021
N 6-Methyladenosine (m6A) is the most prevalent RNA modification on mRNAs and lncRNAs. It plays a pivotal role during various biological processes and disease pathogenesis.
Ma, J, Rigden, DJ, Xu, Q, Rong, R, Tang, Y, Chen, K, Su, J, Meng, J, Song, B, Liu, G, Wu, X, Lu, Z, De Magalhães, JP, Wei, Z   +13 more
core   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, Volume 255, Issue 7, Page 628-645, July 2026.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Introduction to ‘The Epitranscriptome’

RSC Chemical Biology
Ralph Kleiner (Princeton University, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China) introduce the themed collection on ‘The Epitranscriptome’.
Kleiner, Ralph E., Höbartner, Claudia, Jia, Guifang   +2 more
openaire   +3 more sources

Weakly supervised learning of RNA modifications from low-resolution epitranscriptome data [PDF]

, 2021
Motivation: Increasing evidence suggests that post-transcriptional ribonucleic acid (RNA) modifications regulate essential biomolecular functions and are related to the pathogenesis of various diseases. Precise identification of RNA modification sites is
Frans Coenen, Huang, D, Su, J, Coenen, F, Meng, J, Jionglong Su, Song, B, Bowen Song, Jingjue Wei, Daiyun Huang, Jia Meng, Wei, J   +11 more
core   +1 more source

Enhancer RNAs in transcriptional regulation: recent insights

Frontiers in Cell and Developmental Biology, 2023
Enhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse contexts,
Qi Chen, Yaxin Zeng, Jinjin Kang, Minghui Hu, Nianle Li, Kun Sun, Yu Zhao   +6 more
doaj   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Epitranscriptomics in the Heart: a Focus on m6A [PDF]

Current Heart Failure Reports, 2020
Post-transcriptional modifications are key regulators of gene expression that allow the cell to respond to environmental stimuli. The most abundant internal mRNA modification is N6-methyladenosine (m6A), which has been shown to be involved in the regulation of RNA splicing, localization, translation, and decay.
Jacob Z, Longenecker, Christopher J, Gilbert, Volha A, Golubeva, Colton R, Martens, Federica, Accornero   +4 more
openaire   +2 more sources

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

eLife, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson   +8 more
doaj   +1 more source

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source

mRNA epitranscriptomics

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
openaire   +2 more sources