Results 31 to 40 of about 3,547 (209)
RNA Biology, 2022 The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet +3 more
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RNA Modification and Its Implication in Plant Pathogenic Fungi [PDF]
The Plant Pathology Journal, 2021 Interaction of a pathogen with its host plant requires both flexibility and rapid shift in gene expression programs in response to environmental cues associated with host cells. Recently, a growing volume of data on the diversity and ubiquity of internal
Junhyun Jeon, Song Hee Lee
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Molecular Oncology, 2022 N6‐methyladenosine (m6A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m6A in bladder cancer (BlCa) is rather limited, requiring further investigation
Catarina Guimarães‐Teixeira +10 more
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Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome [PDF]
Molecular TherapyKaterina-Marina Pilala +2 more
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Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases
Molecular Therapy: Nucleic Acids, 2023 In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal RNAs, miRNA ...
Xiaohuan Xia, Yi Wang, Jialin C. Zheng
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Frontiers in Genetics, 2021 Epigenetic modifications play an important role in central nervous system disorders. As a widespread posttranscriptional RNA modification, the role of the m5C modification in cerebral ischemia-reperfusion injury (IRI) remains poorly defined.
Huan Jian +31 more
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Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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PEA: an integrated R toolkit for plant epitranscriptome analysis
, 2017 MotivationThe epitranscriptome, also known as chemical modifications of RNA (CMRs), is a newly discovered layer of gene regulation, the biological importance of which emerged through analysis of only a small fraction of CMRs detected by high-throughput ...
Yunjia Tang +4 more
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Charting new territory: The Plasmodium falciparum tRNA modification landscape
Biomedical JournalRibonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee +3 more
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Progress and application of epitranscriptomic m6A modification in gastric cancer
RNA Biology, 2022 The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
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