Results 31 to 40 of about 2,923 (177)
The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
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m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity
Frontiers in Endocrinology, 2021 BackgroundN6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications on mRNA influencing mRNA metabolism. There is emerging evidence for its implication in metabolic disease.
Torunn Rønningen +12 more
doaj +1 more source
Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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Life, 2021 METTL16 methyltransferase is responsible for the methylation of N6-adenosine (m6A) in several RNAs. In mouse cells, we showed that the nuclear distribution of METTL16 is cell cycle-specific. In the G1/S phases, METTL16 accumulates to the nucleolus, while
Lenka Stixová +4 more
doaj +1 more source
Epitranscriptomics of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2022 Recent studies on the epitranscriptomic code of SARS-CoV-2 infection have discovered various RNA modifications, such as N6-methyladenosine (m6A), pseudouridine (Ψ), and 2′-O-methylation (Nm).
Amin Izadpanah +4 more
doaj +1 more source
The Epitranscriptome in Translation Regulation [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer +3 more
openaire +2 more sources
Charting new territory: The Plasmodium falciparum tRNA modification landscape
Biomedical JournalRibonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee +3 more
doaj +1 more source
Molecular Therapy: Nucleic AcidsCancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia +10 more
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The Role of Epitranscriptomic Modifications in the Regulation of RNA–Protein Interactions
BioChem, 2022 Epitranscriptome refers to post-transcriptional modifications to RNA and their associated regulatory factors that can govern changes in an organism’s cells in response to various environmental stimuli.
Elzbieta Wanowska +2 more
doaj +1 more source
iMetaMed, EarlyView.Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo +4 more
wiley +1 more source