Results 11 to 20 of about 4,508 (221)

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

eLife, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson   +8 more
doaj   +5 more sources

Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism [PDF]

Advanced Science
Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Meng Yang, Xiaoqi Zheng, Jiajun Fan, Wei Cheng, Tong‐Meng Yan, Yushan Lai, Nianping Zhang, Yi Lu, Jiali Qi, Zhengyi Huo, Zihe Xu, Jia Huang, Yuting Jiao, Biaodi Liu, Rui Pang, Xiang Zhong, Shi Huang, Guan‐Zheng Luo, Gina Lee, Christian Jobin, A. Murat Eren, Eugene B Chang, Hong Wei, Tao Pan, Xiaoyun Wang   +24 more
doaj   +3 more sources

Environmental epitranscriptomics [PDF]

Environmental Research, 2020
Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Cayir, Akin, Byun, Hyang-Min, Barrow, Timothy   +2 more
openaire   +4 more sources

Spliceosomal snRNA Epitranscriptomics [PDF]

Frontiers in Genetics, 2021
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present
Pedro Morais, Hironori Adachi, Yi-Tao Yu
openaire   +3 more sources

Viral Epitranscriptomics [PDF]

Journal of Virology, 2017
ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy, David G, Courtney, Kevin, Tsai, Bryan R, Cullen   +3 more
openaire   +2 more sources

Translating the epitranscriptome [PDF]

WIREs RNA, 2016
RNAmodifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been ...
Hoernes, Thomas Philipp, Erlacher, Matthias David   +1 more
openaire   +2 more sources

Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome [PDF]

Molecular Therapy
Konstantina Panoutsopoulou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala   +2 more
exaly   +2 more sources

The advantages of SMRT sequencing [PDF]

, 2013
Of the current next-generation sequencing technologies, SMRT sequencing is sometimes overlooked. However, attributes such as long reads, modified base detection and high accuracy make SMRT a useful technology and an ideal approach to the complete ...
Carneiro, M. O., Roberts, R. J., Schatz, M. C.   +2 more
core   +3 more sources

Positioning Europe for the EPITRANSCRIPTOMICS challenge [PDF]

, 2018
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built.
Almeida, Raquel, Ameres, Stefan, Ayers, Duncan, Balatsos, Nikolaos, Ballana, Ester, Bankovic, Jasna, Banovic, Bojana, Baranov, Pavel, Bousquet-Antonelli, Cecile, Bujnicki, Janusz, Cardona, Fernando, Carre, Clement, Costache, Marieta, Cowling, Victoria, Dahl, John Arne, Davalos, Alberto, David, Alexandre, Demircan, Turan, Dinnyes, Andras, Drablos, Finn, Fray, Rupert, Frye, Michaela, Fuks, Francois, Helm, Mark, Holodnuka Kholodnyuk, Irina, Jantsch, Michael, Jeronimo, Carmen, Kelly, Vincent, Klungland, Arne, Kyselovic, Jan, Lafontaine, Denis, Lamm, Ayelet, Liepins, Janis, Lyko, Frank, Macias-Gonzales, Manuel, Motorin, Yuri, Neagu, Monica, Nielsen, Henrik, O Carroll, Donal, O'Connell, Mary, Ohman, Marie, Oulas, Anastasis, Pelizzola, Mattia, Pir, Pinar, Purta, Elzbieta, Quattrone, Alessandro, Rechavi, Gideon, Roignant, Jean-Yves, Rossmanith, Walter, Schaffrath, Raffael, Schwartz, Schraga, Schäfer, Matthias, Selbert, Stefan, Timotijevic, Gordana, Ule, Jernej, Valor, Luis Miguel, Vanacova, Stepanka, Verdel, Andre, Willems, Luc, Zammit, Vanessa   +59 more
core   +13 more sources

Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core   +1 more source