Results 11 to 20 of about 3,251 (178)

Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics

Computational and Structural Biotechnology Journal, 2020
Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications ...
Jionglong Su, Lian Liu, Yufei Huang
exaly   +3 more sources

Recent advances in the plant epitranscriptome

Genome Biology, 2023
Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for ...
Lisha Shen, Jinqi Ma, Ping Li, Yujin Wu, Hao Yu   +4 more
doaj   +3 more sources

Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism

Advanced Science
Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Xiaoyun Wang
exaly   +2 more sources

Host norepinephrine biases codon-dependent virulence translation in EHEC [PDF]

mSystems
Bacterial pathogens sense host-derived signals to control virulence, yet how these cues shape translation remains unclear. McShane et al. show that the host hormone norepinephrine rewires the tRNA epitranscriptome of enterohemorrhagic Escherichia coli ...
Zeynep Baharoglu
doaj   +2 more sources

Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer

Cellular and Molecular Life Sciences
Post-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng, Xiaoli He, Mingxin Guo, Ying Tang, Guantong Qi, Qian Huang, Wenran Ma, Hong Chen, Yifan Qin, Ruiqi Li, Jin Wang, Yu Liu   +11 more
doaj   +3 more sources

Advanced deep learning strategies in nanopore RNA sequencing [PDF]

RNA Biology
The epitranscriptome comprises chemical modifications found on RNA molecules that play essential roles in co- and post-transcriptional gene regulation.
Crystal Ling, Benjamin Lebeau, Kwoh Chee Keong, Melissa Fullwood   +3 more
doaj   +2 more sources

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing. [PDF]

Microbiologyopen
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Pitt ME, Zhang J, Nguyen ANT, Hall MB, Jebeli L, Featherstone LA, Myers GSA, Scott NE, Coin LJM.   +8 more
europepmc   +2 more sources

The epitranscriptome toolbox [PDF]

Cell, 2022
In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Moshitch-Moshkovitz, Sharon, Dominissini, Dan, Rechavi, Gideon   +2 more
openaire   +2 more sources

Environmental epitranscriptomics [PDF]

Environmental Research, 2020
Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Cayir, Akin, Byun, Hyang-Min, Barrow, Timothy   +2 more
openaire   +4 more sources

Mutant KRAS-m⁶A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target. [PDF]

Adv Sci (Weinh)
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Chen D, Huang P, Tao R, Ji F, Wei Q, Ko LH, Zhou L, Chen H, Cheung A, Kang W, To KF, Yu J, Wong CC.   +12 more
europepmc   +2 more sources